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Jonathan Pritchard

@jkpritch.bsky.social

7.5K followers 1.1K following 240 posts

My lab at Stanford studies human population genetics and complex traits.

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Jonathan Pritchard @jkpritch.bsky.social · Sep 23

Two new chapters from my free online book in human genetics out this weekend!
These complete Part 3 of the book, on human population structure and history:
3.3: Human prehistory [separate thread]
3.4: Ancient DNA: a genetic time capsule [this thread]
web.stanford.edu/group/pritch...

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Jonathan Pritchard @jkpritch.bsky.social · 1d

If you're interested, please email me and my assistant Lily (our emails are on my lab's contact page); please include at least a sentence about yourself, and your cv, to introduce yourself. Let us know if you have major scheduling constraints.

Jonathan Pritchard @jkpritch.bsky.social · 1d

Another possible topic is that we typically hire 1-2 postdocs per year. This year I'd like to add at least one person with functional genomics/single cell/perturb-seq interests, especially relating to immune cells. Our broader lab interests are in popgen and complex traits.

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Jonathan Pritchard @jkpritch.bsky.social · 1d

I'll be very happy to chat about career advice, anything about human genetics, my HG textbook, or absolutely anything else that's on your mind. We'll schedule ~15 min blocks.

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Jonathan Pritchard @jkpritch.bsky.social · 1d

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.

I did this last year and it was great to meet a whole bunch of new people, at all career stages!

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Jonathan Pritchard @jkpritch.bsky.social · 9d

It's the start of the year-long intro course to our Human Biology major. I teach a week on principles of evolution + tree of life, and a week on human evolution and history.

Jonathan Pritchard @jkpritch.bsky.social · 9d

Thanks, love this thread! I was just teaching about this last week, wish I'd had some of these images.

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Jonathan Pritchard @jkpritch.bsky.social · 11d

What question is being debated?

Jonathan Pritchard @jkpritch.bsky.social · 17d

Congratulations! Great book choice!

Jonathan Pritchard @jkpritch.bsky.social · 25d

Thanks for sharing the great news. Wishing you the best for the remainder of the obligated funds.

Jonathan Pritchard @jkpritch.bsky.social · 26d

Thank you, and sorry about the delay... I'm finally making progress on Part 4. I should have some of this out by end of the calendar year and hopefully the rest next spring.

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Reposted by Jonathan Pritchard

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Reposted by Jonathan Pritchard

scverse @scverse.bsky.social · Sep 1

🎉scverse conference 2025 Call for Abstracts DEADLINE EXTENDED! 🎉

We're excited to announce that the deadline to submit abstracts for the scverse Conference 2025 has been extended to September 15, 2025!
🧵

#scverse #scverse2025 #SingleCell #Conference

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Jonathan Pritchard @jkpritch.bsky.social · Aug 29

That's wonderful news, and so well deserved for you and the entire bioRxiv team!

Jonathan Pritchard @jkpritch.bsky.social · Aug 22

Delighted to share some wonderful work by our recent grad Matthew Aguirre on theoretical models of GRNs, and what eQTL data can teach us about these!

Matthew Aguirre @aguirre404.bsky.social · Aug 22

Thrilled to share the second half of my PhD work here!

We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/)

doi.org/10.1101/2025...

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Reposted by Jonathan Pritchard

James Kitchens @kitchensjn.bsky.social · Aug 19

Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.

🔗 arxiv.org/abs/2508.03958

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tskit_arg_visualizer: interactive plotting of ancestral recombination graphs

Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...

arxiv.org

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Reposted by Jonathan Pritchard

scverse @scverse.bsky.social · Aug 19

🧠 Meet the keynote speakers for the 2025 scverse conference!
Panos Roussos, Professor at Icahn School of Medicine at Mount Sinai
🧵

@panosroussos.bsky.social
#scverse #scverse2025 #SingleCell #SpatialTranscriptomics #Conference #Keynote

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Reposted by Jonathan Pritchard

Vijay G. Sankaran @bloodgenes.bsky.social · Aug 15

Grateful for this terrific commentary by @tomonroe.bsky.social in @jclinical-invest.bsky.social on our paper that is out in final print format today: www.jci.org/articles/vie...

Please check it out: www.jci.org/articles/vie...

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Jonathan Pritchard @jkpritch.bsky.social · Aug 13

Thank you Cedric! Thread by the first author Matt Aguirre incoming tomorrow!

Reposted by Jonathan Pritchard

Trends in Genetics @cp-trendsgenetics.bsky.social · Aug 13

"The molecular evolutionary basis of species formation revisited"
by Molly Schumer (@mollyschumer.bsky.social) & colleagues

"The origin of species has long fascinated biologists, but determining the genes [involved] has only recently become possible in non-model organisms."

shorturl.at/wG0B5

Figure 1. Illustration of different genetic and evolutionary mechanisms that can contribute to the evolution of hybrid incompatibilities.

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Reposted by Jonathan Pritchard

Joshua G. Schraiber @jgschraiber.bsky.social · Aug 13

Incredibly proud of this work where we developed a method for understanding the information contained in millions of genomes. Another example of NIH funded research.

The American Journal of Human Genetics @ajhgnews.bsky.social · Aug 13

📣Online NOW!
📄Estimation of demography and mutation rates from one million haploid genomes
🧑‍🤝‍🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social

Estimation of demography and mutation rates from one million haploid genomes

Samples of millions of genomes provide substantial information about recent demography and mutation, but standard population-genetic methods make assumptions not met in these data. We introduce DR EVI...

www.cell.com

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Reposted by Jonathan Pritchard

Jeff Spence @jeffspence.github.io · Aug 8

Cool paper, and -- as expected by how similar the titles are -- dovetails nicely with our work (led by Margaret Antonio, Clemens Weiß, Ziyue Gao, and Susanna Sawyer):

elifesciences.org/articles/79714

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Jonathan Pritchard @jkpritch.bsky.social · Aug 6

Congratulations!! So excited to see what your new lab will achieve!!

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Reposted by Jonathan Pritchard

Roshni Patel @roshnipatel.bsky.social · Aug 6

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

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Reposted by Jonathan Pritchard

Joe Bak-Coleman @jbakcoleman.bsky.social · Aug 6

I think this quote is both unsustainable and unsupported by the analysis in the piece. First and foremost, it portrays fraud as *consuming* science rather than merely growing alongside it. Much of the “fraud” in the paper is just metric gaming whackamole that doesn’t get read, cited or used.

Carl Zimmer @carlzimmer.com · Aug 4

“If these trends are not stopped, science is going to be destroyed." Here's my story on the accelerating growth of systemic research fraud--aka paper mills. Gift link: nyti.ms/45rDirw

Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds

A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half.

nyti.ms

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Reposted by Jonathan Pritchard

Jennifer Ouellette @jenlucpiquant.bsky.social · Jul 31

Critics of de-extinction research hit by mystery smear campaign www.newscientist.com/article/2490...

Critics of de-extinction research hit by mystery smear campaign

Several researchers who have been critical of Colossal Biosciences’ plans to revive extinct animals say they have been targeted by online articles trying to discredit them

www.newscientist.com

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