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Esteban Hoijman

@estebanhoijman.bsky.social

250 followers 310 following 28 posts

Group Leader @ibmb-csic.bsky.social Filming single cell behavior during embryonic development. Interested in mechanics and immunity.

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 18

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

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Reposted by Esteban Hoijman

Esteban Hoijman @estebanhoijman.bsky.social · Aug 8

Thanks for the comment of our paper in @science.org . Our first encounter in development with other organisms.

Stella Hurtley @smhsci.bsky.social · Jul 25

My choice this week in @science.org
www.cell.com/cell-host-mi...

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Esteban Hoijman @estebanhoijman.bsky.social · Sep 4

Now at The Node
Early embryos develop... and eliminate threats thenode.biologists.com/early-embryo...

Early embryos develop... and eliminate threats - the Node

We recently discovered that early embryos can eliminate bacterial infections before immune cells are formed. Take a look at the dynamics of our first encounter with microbes.

thenode.biologists.com

Esteban Hoijman @estebanhoijman.bsky.social · Aug 8

Thanks for the comment of our paper in @science.org . Our first encounter in development with other organisms.

Stella Hurtley @smhsci.bsky.social · Jul 25

My choice this week in @science.org
www.cell.com/cell-host-mi...

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Esteban Hoijman @estebanhoijman.bsky.social · Jul 2

Thanks Hanna!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 30

Thanks Juan!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 29

Thanks!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks!!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks Alejo!!

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks Marta!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks!!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks Marc!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 26

Thanks!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Thanks!!

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Our work highlights the urgent need to better define bacterial populations able to colonize or reside in the human uterus and to increase visibility of infection-related uterine diseases and their possible link to infertility. 9/9

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Our work reveals that, beyond proliferation, fate specification, tissue morphogenesis, and implantation, early embryonic cells also play biological defense roles well before organ formation. 8/9

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Functional experiments with engineered bacteria show that phagocytic clearance improves normal developmental progression after infection, emphasizing its key defensive role. 7/9

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Transcriptomic analysis after bacterial challenge showed that epithelial cells activate a full set of immune genes regulated by NF-κB, including proinflammatory cytokines, antibacterial proteins, and pattern recognition receptors. 6/9

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Quantitative imaging and in vivo single-cell interference revealed the dynamics and key regulators of phagocytic protrusions for bacterial internalization, still poorly understood in immune cells. We also identified tissue-scale patterns shaped by bacterial motility. 5/9

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

We also modeled these infections in early zebrafish embryos, enabling us to observe bacterial clearance dynamics by epithelial cells across scales—from subcellular to tissue-level behaviors. 4/9

Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Since bacterial infections are common in the human uterus, we asked how preimplantation embryos respond to microorganisms. We found that, long before myeloid immune cells develop, human embryos phagocytose and destroy certain bacteria infecting the uterus, such as S. aureus. 3/9

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Extraordinary achievement of Joan Roncero, a talented PhD student who tackled every challenge, with key contributions from June Olaizola. Thanks also to Irimia Lab @crg.eu, Veiga Lab @idibell.bsky.social, Torrents & Ojosnegros Labs @ibecbarcelona.eu, Miquel Solé @dexeus, and Alsina Lab @upf.edu 2/9

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 19

Our paper is now published! The first encounter of a forming organism with bacteria reveals that innate immunity initiates in epithelial cells of early embryos, even in humans. www.cell.com/cell-host-mi...
made in @ibmb-csic.bsky.social @csic.es @idibell.bsky.social 1/9

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 18

Thanks! You could like this one of the zipper on a phagocytic protrusion

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 18

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

5 31 110