Research shows that improved diet quality significantly enhances life expectancy in frail older adults, highlighting the importance of nutrition in aging.

N-acetylcysteine (NAC) functions as both a direct antioxidant agent and precursor for glutathione synthesis, both of which are implicated in the patho…

Global cerebral ischemia (GCI) caused by impaired blood flow to the brain—typically following cardiac arrest or traumatic brain injury—remains the leading cause of coma and disorders of consciousness (DoC). In certain cases, the recovery potential of these patients may be significantly underestimated. Historically, these patients were often given little hope for recovery, particularly due to longstanding, outdated dogmatic views such as the presumed absence of adult neurogenesis. However, recent advances suggest that we have been discounting ongoing mental activity in comatose patients; additionally, emerging evidence shows that some patients in coma retain the capacity for communication through non-traditional means. The authors believe that the exponential progress in the field and the increase of our understanding in neurophysiology, regenerative medicine, and the biology of cellular senescence now makes it plausible to initiate experimental interventions that offer a realistic chance of reversing disorders of consciousness. The proposed strategy involves a two-step therapeutic paradigm: first the use of senolytic approaches to remove senescent cells and reduce neuroinflammatory burden (“clear the debris”); second, stimulation of neural regeneration through stem cell therapies, combined with electrophysiologic/pharmacological stimulation. The authors propose, that this integrated approach offers a novel treatment paradigm to address the previously insurmountable challenge of coma reversal.

The ACA’s expanded assistance ends soon, which could mean higher monthly premiums for farm families and other middle-class Minnesotans, columnist Jill Burcum writes.

California Governor Gavin Newsom said the White House, thwarted by a federal judge in its effort to deploy the Oregon National Guard to Portland, is calling up his state’s Guard troops instead.

Todd EWING, Consultant | Cited by 3,100 | of Stanford University, Stanford (SU) | Read 27 publications | Contact Todd EWING

Chuck the gadgets, the fads and the alarm. Circadian research reveals how important your body’s internal clock is to blissful slumber.