In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

Coronary artery calcium scoring has revolutionized cardiovascular prevention. But in women, it sometimes underestimates the risk.

Experiments performed at a large music festival suggest the bloodsuckers are more attracted to hedonistic attendees

A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human pro...

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Global cerebral ischemia (GCI) caused by impaired blood flow to the brain—typically following cardiac arrest or traumatic brain injury—remains the leading cause of coma and disorders of consciousness (DoC). In certain cases, the recovery potential of these patients may be significantly underestimated. Historically, these patients were often given little hope for recovery, particularly due to longstanding, outdated dogmatic views such as the presumed absence of adult neurogenesis. However, recent advances suggest that we have been discounting ongoing mental activity in comatose patients; additionally, emerging evidence shows that some patients in coma retain the capacity for communication through non-traditional means. The authors believe that the exponential progress in the field and the increase of our understanding in neurophysiology, regenerative medicine, and the biology of cellular senescence now makes it plausible to initiate experimental interventions that offer a realistic chance of reversing disorders of consciousness. The proposed strategy involves a two-step therapeutic paradigm: first the use of senolytic approaches to remove senescent cells and reduce neuroinflammatory burden (“clear the debris”); second, stimulation of neural regeneration through stem cell therapies, combined with electrophysiologic/pharmacological stimulation. The authors propose, that this integrated approach offers a novel treatment paradigm to address the previously insurmountable challenge of coma reversal.

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

Repeated nirmatrelvir/ritonavir treatment in participants with COVID-19 rebound was safe and well tolerated. In this group of participants, there was no cl

Interactions between metabolic interoception and regulation may drive comorbidity between mental and metabolic ill-health.

Background and ObjectivesCognitive disability—defined by the Behavioral Risk Factor Surveillance System (BRFSS) as serious difficulty concentrating, remembering, or making decisions because of a physi...

Unwell with a bad throat and temperature? You may have one of the new Covid strains circulating this autumn.

Rochester General Hospital, the University of Texas Southwestern Medical Center, and Aga Khan University report that applying newer cardiovascular risk equations could sharply reduce the number of mid...

Ibuzatrelvir (1) was recently disclosed and patented by Pfizer for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has received fast-track status from the USA Food an...

The implementation of artificial intelligence (AI) in food packaging is transforming the food industry with groundbreaking technologies to improve foo…

Discussions around global equity and justice in science typically emphasize the lack of diversity in the editorial boards of scientific journals, inequities in authorship, “parachute research,” domina...