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fabianmunder.bsky.social
Fabian Munder
@fabianmunder.bsky.social
100 followers 280 following 3 posts
Postdoc in the Grinter Lab at Bio21, UoM Antibiotic mechanisms| Cryo-EM | Bacterial pathogens | Membrane proteins
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fabianmunder.bsky.social
Fabian Munder @fabianmunder.bsky.social · 16d
Thanks Kate! Lucky that you recommend to do my PhD with Rhys! :)
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fabianmunder.bsky.social
Fabian Munder @fabianmunder.bsky.social · 17d
L-type pyocins inhibit the BAM complex with a mechanism that reminds me of the facehuggers from Alien!
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fabianmunder.bsky.social
Fabian Munder @fabianmunder.bsky.social · 17d
Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell.

doi.org/10.1101/2025...

This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
doi.org
2 4 13
Reposted by Fabian Munder
brettcollins.bsky.social
Brett Collins @brettcollins.bsky.social · 18d
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
9 38
Reposted by Fabian Munder
rhyswg.bsky.social
Rhys Grinter @rhyswg.bsky.social · 18d
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
2 37 70
Reposted by Fabian Munder
rhyswg.bsky.social
Rhys Grinter @rhyswg.bsky.social · May 30
Why make a cofactor when you can get it for free?

Our work, led by @fabianmunder.bsky.social, shows that bacteria from 22 phyla use the high-affinity transporter PqqU to obtain the redox cofactor PQQ from the environment as an alternative to cofactor synthesis.

www.science.org/doi/10.1126/...
High-affinity PQQ import is widespread in Gram-negative bacteria
Diverse bacteria use the high-affinity membrane transport protein PqqU to scavenge the nutrient PQQ from the environment.
www.science.org
2 8 17