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Reposted by Rhys Grinter

Chris H. Hill @chillzaa.bsky.social · 1d

Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...

Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES

Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...

www.biorxiv.org

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Reposted by Rhys Grinter

Nature @nature.com · 1d

Nature research paper: A new paradigm for outer membrane protein biogenesis in the Bacteroidota

go.nature.com/3KvfHiG

A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature

Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.

go.nature.com

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Reposted by Rhys Grinter

Fabian Munder @fabianmunder.bsky.social · 16d

Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell.

doi.org/10.1101/2025...

This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

doi.org

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Reposted by Rhys Grinter

Brett Collins @brettcollins.bsky.social · 18d

This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

www.biorxiv.org

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Rhys Grinter @rhyswg.bsky.social · 18d

This work was a huge team effort led by the extremely talented @fabianmunder.bsky.social.

Many thanks and congratulations to everyone who contributed! Too many to thank here but check out the author list.

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Rhys Grinter @rhyswg.bsky.social · 18d

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

www.biorxiv.org

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Reposted by Rhys Grinter

Cyntia Taveneau @cyntiat.bsky.social · Sep 2

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !

www.cell.com/structure/fu...

Code to complex: AI-driven de novo binder design

In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...

www.cell.com

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Reposted by Rhys Grinter

RCSB Protein Data Bank @rcsbpdb.bsky.social · Aug 31

New engineered protein shows promise as antidote for carbon monoxide poisoning
www.medschool.umaryl...

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Reposted by Rhys Grinter

Boston Protein Design and Modeling Club @bpdmc.org · Aug 13

Fun fact: #bindcraft evolved from a binder design tutorial originally developed for BPDMC!

Come see @martinpacesa.bsky.social tonight at 7pm EDT in Room 181, Building 68, @mit.edu

"BindCraft: one-shot design of functional protein binders"

bpdmc.org

schedule

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

bpdmc.org

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Rhys Grinter @rhyswg.bsky.social · Aug 14

Fingers crossed. 🤞

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Rhys Grinter @rhyswg.bsky.social · Aug 14

Feels GPU related to me. 😒

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Reposted by Rhys Grinter

Sven T. Stripp @stripplab.bsky.social · Aug 8

Next-level hydrogenase fuel cell just dropped, congrats @rhyswg.bsky.social and @greening.bsky.social et al.!

Chris Greening @greening.bsky.social · Aug 8

1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.

Nanoengineered bioanode with oxygen-insensitive hydrogenase for sustainable energy harvesting from atmospheric hydrogen and waste gases

Enzymatic biofuel cells (EBFCs) utilizing hydrogenases to oxidize hydrogen offer a sustainable approach to energy conservation. However, the oxygen se…

www.sciencedirect.com

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Reposted by Rhys Grinter

Chris Greening @greening.bsky.social · Aug 8

1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.

Nanoengineered bioanode with oxygen-insensitive hydrogenase for sustainable energy harvesting from atmospheric hydrogen and waste gases

Enzymatic biofuel cells (EBFCs) utilizing hydrogenases to oxidize hydrogen offer a sustainable approach to energy conservation. However, the oxygen se…

www.sciencedirect.com

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Reposted by Rhys Grinter

PEIPolitical 🇨🇦 @peipolitical.bsky.social · Aug 2

PM Mark Carney 🇨🇦
A new airlift of Canadian aid landed in Gaza today, with thanks to His Majesty King Abdullah II & our Jordanian partners.
Canada is dedicating more than $340 million in aid to address the humanitarian crisis in Gaza & we will ensure it moves forward at the necessary scale. #cdnpoli

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Reposted by Rhys Grinter

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

In this system, bacteria detect phage infection through a sensor protein (YjbH) and respond by severing the infected part of the cell via aberrant division. The rest of the cell survives and continues growing happily, essentially, bacterial autotomy!

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Reposted by Rhys Grinter

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

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Reposted by Rhys Grinter

Alexandre Bonvin @amjjbonvin.bsky.social · Jul 29

A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/

CAPRI Docking

www.capri-docking.org

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Rhys Grinter @rhyswg.bsky.social · Jul 29

When’s the deadline for the next round?

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Reposted by Rhys Grinter

Cameron Thrash @jcamthrash.bsky.social · Jul 28

ATP synthesis driven by atmospheric hydrogen concentrations www.pnas.org/doi/abs/10.1... #jcampubs

ATP synthesis driven by atmospheric hydrogen concentrations | PNAS

All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The un...

www.pnas.org

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Reposted by Rhys Grinter

Martin Pacesa @martinpacesa.bsky.social · Jul 26

Excellent nanomolar peptide design success rates with BindCraft!

AI x Bio Discovery @aixbiobot.bsky.social · Jul 26

Generative Design of High-Affinity Peptides Using BindCraft [new]
De novo designs peptide ligands for proteins. It generated MDM2 binders (nM affinity) and WDR5 binders (sub-µM affinity), with potency improved via stapling.

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Reposted by Rhys Grinter

Martin Pacesa @martinpacesa.bsky.social · Jul 25

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Rhys Grinter @rhyswg.bsky.social · Jul 25

Did you know that some bacteria can generate ATP, the energy currency of life, literally out of thin air? 🌬⚡️

In PNAS today, we show how bacteria can do this using just three enzymes. Honoured to contribute to this study with Christoph von Ballmoos, Chris Greening and Gregory Cook
lnkd.in/gxm8SXxF

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Rhys Grinter

Chris Greening @greening.bsky.social · Jul 25

Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...

ATP synthesis driven by atmospheric hydrogen concentrations | PNAS

All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The un...

www.pnas.org

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Reposted by Rhys Grinter

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · Jul 22

DeepMind will fund CASP for a year. Very nice to hear.

(not paying Stat $30 a month, but you can read the first bit).

www.statnews.com/2025/07/21/c...

AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short

Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.

www.statnews.com

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Reposted by Rhys Grinter

Maciek Wiatrak @macwiatrak.bsky.social · Jul 21

💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.

Preprint 📝: biorxiv.org/content/10.1...

🧵 1/n

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