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Cyntia Taveneau

@cyntiat.bsky.social

190 followers 550 following 9 posts

Group Leader | Structural Biologist Monash University (Melbourne) 🇦🇺 🇨🇵 CryoEM & Protein Design

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Cyntia Taveneau @cyntiat.bsky.social · Dec 10

Excited to share my first-author preprint from the Knott Lab! Using de novo protein design, we developed anti-CRISPRs to potently inhibit CRISPR-Cas13. Thanks to my amazing co-authors !

www.biorxiv.org/content/10.1...

#CRISPR

De novo design of potent CRISPR-Cas13 inhibitors

CRISPR-Cas systems are transformative tools for gene editing which can be tuned or controlled by anti-CRISPRs (Acrs) - phage derived inhibitors that regulate CRISPR-Cas activity. However, Acrs that ar...

www.biorxiv.org

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Cyntia Taveneau @cyntiat.bsky.social · Sep 2

Really happy to have been part of this journey and to co-author this piece with @danielrfox.bsky.social , Janik Clement, @rhyswg.bsky.social and @knottrna.bsky.social !

Cyntia Taveneau @cyntiat.bsky.social · Sep 2

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !

www.cell.com/structure/fu...

Code to complex: AI-driven de novo binder design

In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...

www.cell.com

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Cyntia Taveneau @cyntiat.bsky.social · Aug 5

Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :)

I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors

12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...

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Aude Bernheim @audeber.bsky.social · Jul 24

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

www.science.org

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CCeMMP Outreach @ccemmp-outreach.bsky.social · Jul 15

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c...

#CryoEM
#Membranes

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Kate Michie @kmichie.bsky.social · Jul 2

ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!

WEBINAR SERIES: Leveraging deep learning to design custom protein-binding proteins — Australian BioCommons

Be inspired by case studies that show you how deep learning methods are speeding up the process of designing proteins with desirable biophysical properties. More information Register

www.biocommons.org.au

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Daniel Fox @danielrfox.bsky.social · Jul 10

Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬

Rhys Grinter @rhyswg.bsky.social · Jul 9

Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the ‪‪@knottrna.bsky.social‬ ‬lab, with experimental work led by the talented @danielrfox.bsky.social
www.nature.com/articles/s41...

Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications

Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...

www.nature.com

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Jul 7

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

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Cyntia Taveneau @cyntiat.bsky.social · Jul 4

Exclusive: Famed protein structure competition nears end as NIH grant money runs out

Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold

www.science.org

Reposted by Cyntia Taveneau

Nature @nature.com · May 30

An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots

https://go.nature.com/3ZaM0rD

See the Milky Way dazzle during a lunar eclipse — May’s best science images

The month’s sharpest science shots, selected by Nature’s photo team.

go.nature.com

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Reposted by Cyntia Taveneau

Ben Engel @cellarchlab.com · Mar 20

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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France Culture @franceculture.fr · Mar 17

"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.

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Masaru Nobu @masarunobu.bsky.social · Feb 27

New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology!
www.biorxiv.org/content/10.1...

Eukaryotes' closest relatives are internally simple syntrophic archaea

Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

www.biorxiv.org

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Cyntia Taveneau @cyntiat.bsky.social · Feb 12

It was a fantastic talk, thank you !

Cyntia Taveneau @cyntiat.bsky.social · Feb 12

In love with this movie !

Reposted by Cyntia Taveneau

Lorne Proteins @lorneproteins.bsky.social · Feb 11

Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025

Cas activity assay. 3 strongest inhibitors characterised. Mimic RNAs. Xtallised one. Two others wouldn't xtallise, CD agrees with prediction; also checked folding/stability. Nice candidates for regulation of Cas.

Functional in bacteria. Rescue phage infection as designed. As a crispr off switch - 8 weeks from AI design to targeted inhibitor.

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Aude Bernheim @audeber.bsky.social · Feb 7

Petit reportage de France Inter sur notre utilisation de l'IA au labo:
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...

"On est entré dans un nouveau monde" : comment l'IA révolutionne la microbiologie

En permettant de prédire la structure d'une protéine à partir d'une séquence d'ADN, Alphafold, le système mis au point par Google DeepMind, a ouvert en grand le champ des possibles pour les chercheurs...

www.radiofrance.fr

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AI x Bio Discovery @aixbiobot.bsky.social · Jan 18

Scaling data analyses in cellular cryoET using comprehensive segmentation [new]
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.

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Chen Davidovich @davidovichlab.bsky.social · Jan 16

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology

Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...

www.nature.com

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Ben Engel @cellarchlab.com · Nov 23

After a decade in the oven🧑‍🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base.

📜 https://dir.lat/41qAY4

We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...

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Philippe Van der Stappen @phaips.vd.st · Dec 29

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy!

Check out the preprint: www.biorxiv.org/content/10.1...

Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com

#TeamTomo

Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii

In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...

www.biorxiv.org

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Max Bonomi @bonomimax.bsky.social · Dec 6

Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr

One PhD thesis in integrative structural biology | Research - Institut Pasteur

research.pasteur.fr

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Lorne Proteins @lorneproteins.bsky.social · Dec 18

Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year!
www.lorneproteins.org

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Terradot lab @laurentterradot.bsky.social · Nov 15

A postdoctoral position is available in our team to study the type VI secretion system.
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊

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Cyntia Taveneau @cyntiat.bsky.social · Dec 17

Know this feeling too well 🫠🫠🫠