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Reposted by Chen Davidovich

Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 11d

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026

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Reposted by Chen Davidovich

Jaruwatana (Sodai) Lotharukpong @sodail.bsky.social · 19d

Super glad to contribute to this study on chromatin evolution in brown algae! Special thanks to Jeromine Vigneau, @borglab.bsky.social and Susana Coelho for making this happen.

www.biorxiv.org/content/10.1...

Rewiring of chromatin regulation underlies the evolution of brown algal multicellularity

Chromatin structure plays a central role in regulating transcription, genome stability, and epigenetic inheritance in eukaryotes. Much of our understanding of chromatin architecture and histone post-t...

www.biorxiv.org

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ARC Centre of Excellence in Synthetic Biology @arccoesb.bsky.social · 21d

Genes and Gin: A Synthetic Biology Social 🎉

Join us for a fun night of Genes and Gin - learn to play the synthetic card game "Remediate!", created by a group of researchers within our Centre.

Make sure you register for catering:
www.eventbrite.com.au/e/genes-and-...

See you on the rooftop!

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Samuel King @samuelhking.bsky.social · 21d

Many of the most complex and useful functions in biology emerge at the scale of whole genomes.

Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

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Maxim Greenberg @maxvcg.bsky.social · 23d

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

journals.plos.org

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Anna Schulten @sulteavn.bsky.social · Aug 26

Excited to share the paper from my work in the Dean lab @johninnescentre.bsky.social out now in @cp-molcell.bsky.social. Huge thanks to all the co-authors - it was a great collaborative effort! Watch out for the associated cover artwork coming out next week 🎉 www.cell.com/molecular-ce...

VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing

Schulten et al. show that VEL polymerization domains produce higher-order protein assemblies to maintain chromatin association of Polycomb proteins, enabling a stable epigenetic switch at the floral r...

www.cell.com

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Reposted by Chen Davidovich

Ivano Mocavini @notquitesincere.bsky.social · Aug 25

Finally out on @devbiol.bsky.social‬: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰.

Bonus: Epop has maternal effect!

Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social

The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice

The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC…

www.sciencedirect.com

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Eric Joyce @ericjoyce.bsky.social · Aug 14

🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...

www.biorxiv.org

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Reposted by Chen Davidovich

Yicheng Long @yichenglong.bsky.social · Aug 12

Excited to share our work on the specificity of PRC2 subcomplexes in stem cell and differentiation. We show that PRC2.1 and PRC2.2 exhibit distinct H3K27 methylation specificity in human pluripotent stem cells and opposing role in differentiation. Now online at Mol Cell: www.cell.com/molecular-ce...

Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

Much et al. reveal that the PRC2 subcomplexes PRC2.1 and PRC2.2 play distinct roles in the epigenetic repression of developmental genes in human stem cells. Interactions between the PRC2 core and its ...

www.cell.com

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The Lewis Lab @peterlewislab.bsky.social · Jul 23

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

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H. Courtney Hodges @hodgeshc.bsky.social · Jul 22

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...

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Andrew Deans @genomestability.bsky.social · Jul 22

Register for the Australian Cell Cycle, DNA Repair & Telomere Meeting in beautiful Melbourne October 19-22, 2025. Plenty of slots for selected abstracts and posters. High praise last time from Piotr Sicinski: "en par with a Gordon conference for science and interaction"
www.australiancellcycle.org

Australian Cell Cycle, DNA repair and Telomere Meeting

October 20-22, 2025

www.australiancellcycle.org

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Reposted by Chen Davidovich

Shelby Blythe @shelbyflies.bsky.social · Jul 3

Happy to announce a new preprint from my lab looking in to the establishment of polycomb domains in early fly development and contributions from pioneer factors Zelda and GAGA-factor.

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Jul 3

Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition https://www.biorxiv.org/content/10.1101/2025.07.02.662854v1

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Winnie Tan @winn5tan.bsky.social · Jul 2

✨Excited to share my first postdoc paper on chromatin remodeler, MORC2 ✨

Using #cryoEM & #singlemolecule imaging, we reveal how MORC2 compacts DNA 🔬🧬

Thanks to all collaborators from @wehi-research.bsky.social @ccemmp-outreach.bsky.social Uni Melb, Monash Uni, Seoul National Uni and Texas Uni!

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · Jul 2

Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments.

www.nature.com/articles/s41...

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Reposted by Chen Davidovich

Nadav Ahituv @nadavahituv.bsky.social · Jul 1

Lentivirus massively parallel reporter assays integrate & enrich for specific sequences in the genome. We utilize this to test their epigenetic modifications & open chromatin alongside their regulatory activity. Amazing work by Zicong Zhang, Fumitaka Inoue & others.
www.biorxiv.org/content/10.1...

Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA

Cis-regulatory elements (CREs) have a major effect on phenotypes including disease. They are identified in a genome-wide manner by analyzing the binding of transcription factors (TFs), various co-fact...

www.biorxiv.org

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The Lewis Lab @peterlewislab.bsky.social · May 27

New from our lab & @harrisonflylab.bsky.social: Drosophila models of H3 K27M & EZHIP reveal conserved chromatin regulators that buffer PRC2 inhibition. An in vivo screen highlights how developmental defects can be rescued despite global H3K27me3 loss.
doi.org/10.1101/2025...

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Jakob Trendel @jtrend.bsky.social · May 23

Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵

The human proteome with direct physical access to DNA

Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-aci...

www.cell.com

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Alex Holehouse @alexholehouse.bsky.social · May 23

Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...

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Beat Fierz @beatfierz.bsky.social · May 21

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

www.science.org

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Reposted by Chen Davidovich

LCBM @lcbm-epfl.bsky.social · May 22

Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

www.science.org

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Reposted by Chen Davidovich

Adrian Bracken @adrianbracken.bsky.social · May 21

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Eimear Lagan @eimearlagan.bsky.social · May 21

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

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Yicheng Long @yichenglong.bsky.social · May 16

Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...

Macromolecular interactions dictate Polycomb-mediated epigenetic repression

The dynamic regulation of epigenetic states relies on complex macromolecular interactions. PRC2, the methyltransferase complex responsible for depositing H3K27me3, interacts with distinct accessory pr...

www.biorxiv.org

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Reposted by Chen Davidovich

Addgene @addgene.bsky.social · May 15

Big thanks to @davidovichlab.bsky.social for sharing this toolkit! Check it out here: www.addgene.org/kits/davidovich-moclo-baculo/

Chen Davidovich @davidovichlab.bsky.social · May 15

Big thanks to @addgene.bsky.social for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together:
www.addgene.org/kits/davidov...
🧪🧬 #MolecularCloning #baculovirus #ProteinExpression

Addgene: MoClo Baculo Toolkit

Use the MoClo Baculo Toolkit to efficiently generate multigene expression constructs for the baculovirus expression system.

www.addgene.org

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Reposted by Chen Davidovich

Andrew Deans @genomestability.bsky.social · May 15

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

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Chen Davidovich @davidovichlab.bsky.social · May 15

Big thanks to @addgene.bsky.social for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together:
www.addgene.org/kits/davidov...
🧪🧬 #MolecularCloning #baculovirus #ProteinExpression

Addgene: MoClo Baculo Toolkit

Use the MoClo Baculo Toolkit to efficiently generate multigene expression constructs for the baculovirus expression system.

www.addgene.org

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