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Reposted by Adrian Bracken

Eric Conway @conwayer1.bsky.social · Aug 27

Delighted that our work on EZH2 dominant negativity in Weaver syndrome is now out in Genes & Development!

This exciting work on chromatinopathies 🧬 was in collab with @adrianbracken.bsky.social and spearheaded by Orla Deevy.

@ucddublin.bsky.social @ucd-sbbs.bsky.social

www.ucd.ie/newsandopini...

UCD co-lead breakthrough discovering genetic mechanism driving Weaver syndrome

www.ucd.ie

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Adrian Bracken @adrianbracken.bsky.social · May 21

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Eimear Lagan @eimearlagan.bsky.social · May 21

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

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EpiCypher @epicypher.bsky.social · Mar 24

🧬🧪Exciting chromatin research conference hosted by @aicc-ireland.bsky.social in May! The deadline for poster/talk abstracts is April 28, see details in the post below.

All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Mar 24

We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!

Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!

allirelandchromatinconsortium.ie/annual-meeti...

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Mar 24

We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!

Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!

allirelandchromatinconsortium.ie/annual-meeti...

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Chen Davidovich @davidovichlab.bsky.social · Mar 15

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?

We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Mar 13

Looking forward to welcoming @peterlewislab.bsky.social from @uwmadison.bsky.social for our March webinar on 'Dissecting the Biochemical Complexes Governing Gene Silencing' on March 28th!

Register here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Mar 3

What a week it has been for our @uniofgalway.bsky.social committee members @jgahan.bsky.social and @thecocodium.bsky.social. Congrats on the grant successes from @researchireland.bsky.social and @wellcometrust.bsky.social respectively!

Keep an eye out for job ads from them soon 👀

James Gahan @jgahan.bsky.social · Mar 3

More great news! The CCB is on fire at the moment. If you are looking for opportunities to join a successful (and friendly) group of Chromosome biologists, either as a PhD/Postdoc or group leader, then get in touch:
chromosome.ie

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Feb 11

Coming up this month on Feb 28th- we will be joined by @arnausebe.bsky.social from the @crg.eu for his webinar on 'The origin and early evolution of animal regulatory genome architecture'.

Registration details here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

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Genetics Society UK @gensocuk.bsky.social · Jan 21

Just a few days left to submit your abstract for our #Epigenetics2025 conference in Belfast!

genetics.org.uk/events/epige...

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Genetics Society UK @gensocuk.bsky.social · Jan 17

Join us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb!

Don't miss this chance to share your research & network with experts in the field.

genetics.org.uk/events/epige...

Epigenetics-2025, from mechanisms to disease | Genetics Society

Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...

genetics.org.uk

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Karim-Jean Armache @kjarmache.bsky.social · Jan 15

Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.

Adrian Bracken @adrianbracken.bsky.social · Jan 14

Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

Evan Healy @evhealy.bsky.social · Jan 14

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

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Adrian Bracken @adrianbracken.bsky.social · Jan 14

Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

Evan Healy @evhealy.bsky.social · Jan 14

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Jan 8

Our first 2025 webinar is coming up in a few weeks - Jan 31st! Mark your calendars!

@davidlabmsk.bsky.social will join us for her webinar on 'Turning back the clock: Targeting a new metabolism-epigenetic axis in T-cells.'

Registration: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

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Adrian Bracken @adrianbracken.bsky.social · Dec 11

Join us for Luciano Di Croce’s webinar tomorrow. Registration links below 👇

All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Dec 4

Our final webinar before Christmas 🎅 is coming up!

We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.

Register here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Dec 4

Our final webinar before Christmas 🎅 is coming up!

We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.

Register here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

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Adrian Bracken @adrianbracken.bsky.social · Nov 26

Looking forward to connecting with fellow science nerds!! 😀 🧬

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Adrian Bracken @adrianbracken.bsky.social · Nov 26

Thank you!

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Adrian Bracken @adrianbracken.bsky.social · Nov 25

Please add me Duncan - thanks! hope all’s well with you

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Duncan Sproul @sproullab.bsky.social · Nov 25

We've now filled one #Epigenetics, Chromatin and Gene regulation starter pack. Thanks for all the enthusiasm and support, if you'd like to be listed @raduzabet.bsky.social has been hard at work getting part II up and running:
go.bsky.app/SqLa3aw

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All-Ireland Chromatin Consortium @aicc-ireland.bsky.social · Nov 19

Of course, being new to bluesky we managed to forget to add the all important registration link 🤦‍♂️

Register here: us06web.zoom.us/webinar/regi...

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Evan Healy @evhealy.bsky.social · Nov 20

How does PRC1 counteract transcription?

See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.

www.sciencedirect.com/science/arti...

@conwayer1.bsky.social for title inspo!

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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