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Karim-Jean Armache @kjarmache.bsky.social · 22d

In this meeting, a special focus will be given to promoting new connectivities among all participants spanning career stages and the academic and biopharmaceutical sectors.

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Karim-Jean Armache @kjarmache.bsky.social · 22d

You will not want to miss this lineup of star investigators which has been assembled to capture interdisciplinary approaches toward linking basic chromatin and gene regulatory mechanisms with therapeutic opportunities. #Epigenetics #generegulation #chromatinarchitecture

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Karim-Jean Armache @kjarmache.bsky.social · 22d

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia

Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

keysym.us

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Reposted by Karim-Jean Armache

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Jun 10

2nd Meeting on Epigenetics & Epigenomics - 24th - 26th September, Brussels 🇧🇪

Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social

www.xcellsconferences.com/epigenetics2...

Epigenetics 2025 | Xcells Conferences

www.xcellsconferences.com

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Reposted by Karim-Jean Armache

Samara Reck-Peterson @samreckpeterson.bsky.social · May 13

As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...

Director of Research, Biochemistry & Biophysics

jobs.weill.cornell.edu

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Reposted by Karim-Jean Armache

Yael David @davidlabmsk.bsky.social · May 5

Excited for this summer’s NYC Chromatin Club!

Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!

#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social

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Karim-Jean Armache @kjarmache.bsky.social · Apr 30

Hahaha

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Karim-Jean Armache @kjarmache.bsky.social · Mar 11

Congrats Effie and team!

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Karim-Jean Armache @kjarmache.bsky.social · Feb 22

Congrats Yael and colleagues!

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Karim-Jean Armache @kjarmache.bsky.social · Feb 21

Great work! Congrats Anja and colleagues!

The Groth lab @grothlab.bsky.social · Feb 19

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

tinyurl.com

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Karim-Jean Armache @kjarmache.bsky.social · Feb 15

Congrats Max! Wonderful news

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Karim-Jean Armache @kjarmache.bsky.social · Feb 5

Structural biology of native transcription complexes! Congrats JP and team!

Jean-Paul Armache @valendraica.bsky.social · Feb 5

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

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Karim-Jean Armache @kjarmache.bsky.social · Jan 15

Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.

Adrian Bracken @adrianbracken.bsky.social · Jan 14

Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

Evan Healy @evhealy.bsky.social · Jan 14

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

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Karim-Jean Armache @kjarmache.bsky.social · Jan 3

Congrats Ale, Zawar and colleagues! This is great work.

Alessandro Vannini @alessandrovannini.bsky.social · Jan 3

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41...

A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications

The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...

www.nature.com

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Karim-Jean Armache @kjarmache.bsky.social · Dec 22

Thanks Micha!

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Karim-Jean Armache @kjarmache.bsky.social · Dec 13

Congrats Mark and colleagues, very interesting paper

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Karim-Jean Armache @kjarmache.bsky.social · Dec 8

Congrats Hiten et al!

Hiten Madhani @hitenmadhani.bsky.social · Oct 24

Check out our work that aims to decipher Cryptococcus neoformans on an global scale. 4300 knockout strains, 142 genetic screens, 6 in depth follow up stories (too many to summarize here, but rach is cool!). AlphaFold, AP-MS, microscopy, secretomics, mice, machine learning and more.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Oct 23

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology https://www.biorxiv.org/content/10.1101/2024.10.22.619677v1

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Karim-Jean Armache @kjarmache.bsky.social · Dec 3

Congrats

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Karim-Jean Armache @kjarmache.bsky.social · Dec 3

Very nice work Micha and colleagues. Congrats

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Reposted by Karim-Jean Armache

Karim-Jean Armache @kjarmache.bsky.social · Nov 13

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ

Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1

Nature - Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their...

rdcu.be

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Karim-Jean Armache @kjarmache.bsky.social · Nov 27

Well done! Congrats Rob and colleagues.

Rob Klose @robklose.bsky.social · Nov 26

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.

Jess Kelley @jesskelley.bsky.social · Nov 26

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

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Karim-Jean Armache @kjarmache.bsky.social · Nov 20

Thanks Lluis!

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Karim-Jean Armache @kjarmache.bsky.social · Nov 18

Thanks Max!

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Karim-Jean Armache @kjarmache.bsky.social · Nov 16

So much fun!

Yael David @davidlabmsk.bsky.social · Nov 16

East coast chromatin mafia
@kjarmache.bsky.social

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Karim-Jean Armache @kjarmache.bsky.social · Nov 16

This paper marks our trilogy on H2AK119Ub mechanisms. We have now characterized: PRC1 (the Writer), BAP1/ASXL1 (the Eraser) and DNMT3A1 (the Reader) of H2AK119Ub in collaboration with the amazing labs of Chao Lu, JP Armache, Diego Pasini, Mike Keogh and the Epicypher and Evgeny Nudler.

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