Thanks Aidan! Very on-point comment, I appreciate it - and you are right. Often, one tries to simplify the system by limiting the number of variables for a single study - but in reality it seems more like an elaborate albeit stochastic ballet dance :)

We coupled in depth mutagenesis and biochemistry with high-resolution cryoEM, obtaining maps ranging from 2.37 to 2.9 Å.

This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab)

Thank you to everyone involved. It was a fun joint-venture!

Thank you🙏

New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...

This was a highly collaborative work between multiple labs, performed by a talented grad student in the Armache and Murakami labs, Natalie Smith. Thank you to all the authors for their incredible work!

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ