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Reposted by Jess Kelley

👻madeline boOoOoOodent👻 @oldenoughtosay.com · 16d

Time to talk about one of my favourite Oxford buildings, 26-27-28 Cornmarket!!

Popularly known as The Old Pret

A timber framed jettied building, with two distinctive sections

Jess Kelley @jesskelley.bsky.social · Sep 5

If you're looking for Oxford local news that actually reports local news, the Oxford Clarion is worth a follow and subscribe!

Oxford Clarion @oxfordclarion.bsky.social · Sep 5

Oxfordshire’s weekly news update with all the stories we’ve broken this week:
✅ 10,000-home new town in North Oxfordshire
✅ Why Oxford–Milton Keynes trains haven’t started
✅ The new café run by monks
❌ Cotswold celebrities and Emma Watson
Read it online or by email: oxfordclarion.uk/clarion-week...

Clarion Weekly, 5 September 2025

Kids are back at school, traffic is back… and the news never went away. We bring you a smorgasbord of exclusives, events and some dodgy monastic puns. Trigger warning: there is a picture of a spider i...

oxfordclarion.uk

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Reposted by Jess Kelley

ErrantScience @errantscience.com · Jun 19

Who can work in science, EVERYONE #pride

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EPIGENETIC HULK @epigenetichulk.bsky.social · Jun 13

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

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Reposted by Jess Kelley

Lucas Farnung @lucas.farnunglab.com · Apr 6

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

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Randall Munroe @xkcd.com · Feb 26

RNA xkcd.com/3056

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Oxford Biochemistry @oxfordbiochemistry.bsky.social · Feb 10

Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose

Unlocking the Pause: A new player in gene transcription

A new work from the Klose lab published in the journal Molecular Cell

bit.ly

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Jess Kelley @jesskelley.bsky.social · Feb 10

Please could you correct the spelling on my tag in this? I'm sure Jess Kelly doesn't want the random notifications either!

Reposted by Jess Kelley

Lars Jansen Lab @jansenlab.bsky.social · Feb 5

@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...

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Reposted by Jess Kelley

Dr. Headbutt 🌈🧪 @nicoleackermans.com · Jan 25

I love scientists

Dan Lurie @danjlurie.bsky.social · Jan 25

Delightful and insightful paper on phase behavior in pasta sauce. Includes an optimized recipe for cacio e pepe which helps avoid the dreaded clumpy "Mozzarella phase".

Can't wait for a follow-up on lasagna manifolds.

arxiv.org/abs/2501.00536

Phase behavior of Cacio and Pepe sauce

"Pasta alla Cacio e pepe" is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect texture and creaminess of the sauce can ...

arxiv.org

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Reposted by Jess Kelley

Anna Landre @annalandre.com · Jan 7

Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?

Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT

More info: www.ucl.ac.uk/ucl-east/new...

Two photos of Anna, a young white woman using an electric wheelchair, wearing a blue lab coat that fits her well with tables and dry-lab equipment in the background. Text reads: "A team of researchers and designers led by UCL is looking for wheelchair users working in wet lab environments to user-test what is believed to be the first-ever prototype of a lab coat adapted for wheelchair users."

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Rhodri Marsden @rhodri.biz · Dec 24

So I'll be back around then. We'll be trying to raise a bit of money for Centrepoint, bearing in mind that there are a bunch of people who have nowhere to go this evening. gofund.me/637d21d0 ENDS FOR NOW 🎄🛏️

Donate to Duvet Know It's Christmas, 2024, organized by Rhodri Marsden

Unbelievably, it's the 14th year of this thing. What is it? Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2024

gofund.me

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Jess Kelley @jesskelley.bsky.social · Dec 24

I finally get to join an honoured festive tradition in #DuvetKnowItsChristmas
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa

Photo of an airbed set up with a sleeping bag and pillows, on the floor in front of a TV and Christmas tree. There is a two-seat green sofa and a grey folding camping chair around it.

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Reposted by Jess Kelley

Chaz Hutton @chazhutton.com · Dec 11

Googling Stuff: Then v Now.

This title if the comic is ‘Googling Stuff…’
The comic shows two columns: on the left is “Then” showing search results with one thing listed as “the thing you want”

On the right column is ‘Now’ - also showing search results but in this case it’s a whole bunch of stuff you don’t need:

AI TAKING A WILD STAB AT IT WITH SOME
BLATANT MISINFORMATION

SPONSORED RESULT

SPONSORED RESULT

SPONSORED RESULT

SPONSORED RESULT

PEOPLE ALSO ASK

VIEW PRODUCTS

And then right at the bottom just off screen is ‘the thing you want’

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Reposted by Jess Kelley

Emilia Dimitrova @edimitrova.bsky.social · Dec 12

We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!

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Reposted by Jess Kelley

Kavli Institute for Nanoscience Discovery, University of Oxford @kavlioxford.bsky.social · Dec 5

Join Oxford Biological Physics! #KavliOxford is inviting applications for Fellows to establish independent research groups in this dynamic, interdisciplinary field. Apply now: kavli.web.ox.ac.uk/article/2025...

2025 Application Round for Fellows in Oxford Biological Physics

kavli.web.ox.ac.uk

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Reposted by Jess Kelley

Emily @emily-405.bsky.social · Nov 29

Turns out that, for me, news sites are a great way to become usefully informed about what's happening in the world, and Twitter is a great way to get uselessly stressed about it.

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Jess Kelley @jesskelley.bsky.social · Nov 27

Thank you! We had an amazing team on this project with everyone contributing their own unique expertise to tackle a tricky problem!

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Jess Kelley @jesskelley.bsky.social · Nov 27

Nice thread collating all these exciting new reviews! My 'to read' list has definitely just got even longer...

Craig Kaplan @triggerloop.bsky.social · Nov 27

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Controlling Transcription Elongation and Termination: More Than a Means to An End

www.sciencedirect.com

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Reposted by Jess Kelley

Emilia Dimitrova @edimitrova.bsky.social · Nov 27

On the reading list

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Nov 27

A special JMB issue on Transcription elongation and termination with really great reviews including @triggerloop.bsky.social @voslab.org @lucas.farnunglab.com

www.sciencedirect.com/science/arti...

Controlling Transcription Elongation and Termination: More Than a Means to An End

www.sciencedirect.com

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Reposted by Jess Kelley

James Gahan @jgahan.bsky.social · Nov 27

This paper is genuinely amazing! Not only is the science very cool, it is also a masterclass in scientific writing, as are most @robklose.bsky.social lab papers!

Jess Kelley @jesskelley.bsky.social · Nov 26

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

The PNUTS phosphatase complex controls transcription pause release

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...

www.cell.com

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Jess Kelley @jesskelley.bsky.social · Nov 27

Repost for the morning crowd! ICYMI, our new paper on PNUTS-PP1 in transcription pause release is out now:

Jess Kelley @jesskelley.bsky.social · Nov 26

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

The PNUTS phosphatase complex controls transcription pause release

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...

www.cell.com

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Reposted by Jess Kelley

Emilia Dimitrova @edimitrova.bsky.social · Nov 26

Go team PNUTS! @jesskelley.bsky.social @aleksszczurek.bsky.social @neilblackledge.bsky.social @robklose.bsky.social and Maciek!

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Jess Kelley @jesskelley.bsky.social · Nov 26

And as a final bonus, do also take a look at the complementary study from Fei Xavier Chen’s lab, who describe a similar role for PNUTS-PP1 in a human cell system: www.cell.com/molecular-ce...

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release

The major cellular protein phosphatases are widely recognized as transcriptional repressors. However, Wang et al. identify the PP1 phosphatase as a global transcriptional activator that activates paus...

www.cell.com

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Jess Kelley @jesskelley.bsky.social · Nov 26

Final note: The success of this project relied on collaboration. We couldn’t have done it without bringing together different approaches, from genomics and proteomics to biochemistry to live-cell imaging. Every author put in a lot of hard work and I’m so proud to share credit with them all (8/8)

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