Oxford Biochemistry
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The Department of Biochemistry at the University of Oxford
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Shabaz Lab
@shabazlab.bsky.social
· Jul 1
Thio-NHS esters are non-innocent protein acylating reagents - Nature Communications
N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide to afford N-succinamide de...
www.nature.com
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Rebecca Berrens
@rberrens.bsky.social
· Jul 16
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Elena Poser
@eleposer.bsky.social
· Jul 16
A pivot-tether model for nucleosome recognition by the chromosomal passenger complex | EMBO reports
imageimageAurora B is targeted to chromatin subdomains by the chromosome passenger complex,
formed by survivin, borealin and INCENP. Spatial restriction of Aurora B adjacent
to kinetochores is importa...
www.embopress.org
Reposted by Oxford Biochemistry
Reposted by Oxford Biochemistry
Tomoaki Sobajima
@tomogolgier.bsky.social
· Jun 23
WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer | The EMBO Journal
imageimageProlonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest
in G1. This work shows how these pathways normally lead to G1 arrest by different
routes, and how cancer-a...
www.embopress.org
Reposted by Oxford Biochemistry
Reposted by Oxford Biochemistry