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fgh-lab.bsky.social
Fernando Gomez-Herreros Lab
@fgh-lab.bsky.social
250 followers 390 following 2 posts
DNA Repair and Gene expression in human disease. Andalusian research lab. Find us at the Institute of Biomedicine of Sevilla https://grupo.us.es/gomezherreroslab/gomezherreroslab/Home.html
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fgh-lab.bsky.social
Fernando Gomez-Herreros Lab @fgh-lab.bsky.social · Jul 29
Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene
Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com
1 3 8
Reposted by Fernando Gomez-Herreros Lab
corteslab.bsky.social
CortésLab @corteslab.bsky.social · 5d
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
www.science.org
7 26 71
Reposted by Fernando Gomez-Herreros Lab
gdsc-sussex.bsky.social
Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Sep 3
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
9 11
fgh-lab.bsky.social
Fernando Gomez-Herreros Lab @fgh-lab.bsky.social · Jul 29
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors

Grateful to all collaborators who made this work possible!
1
fgh-lab.bsky.social
Fernando Gomez-Herreros Lab @fgh-lab.bsky.social · Jul 29
Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene
Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com
1 3 8
Reposted by Fernando Gomez-Herreros Lab
romangp.bsky.social
Román González-Prieto @romangp.bsky.social · Apr 28
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.

www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
www.biorxiv.org
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