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Reposted by Florian Schueder

Paolo De Los Rios @paolodelosrios.bsky.social · Aug 22

Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well.
Together with @fcaredda.bsky.social @lgennai.bsky.social and bluesky-absent Andrea Pagnani.

www.biorxiv.org/content/10.1...

Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components

We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can levera...

www.biorxiv.org

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Reposted by Florian Schueder

Luciano A. Masullo @lumasullo.bsky.social · Jul 30

Ångström-resolution imaging of cell-surface glycans

Now published in Nature Nanotechnology! 🤩
@natnano.nature.com

www.nature.com/articles/s41...

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Florian Schueder @florianschueder.bsky.social · Jul 31

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → [email protected]
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

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Florian Schueder @florianschueder.bsky.social · Jul 23

🔬🧬 New in @natcomms.nature.com‬: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess 

www.nature.com/articles/s41...

@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications

A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

www.nature.com

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Florian Schueder @florianschueder.bsky.social · May 25

Thank you Romain!

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Florian Schueder @florianschueder.bsky.social · May 25

Thank you Yongdeng!!

Florian Schueder @florianschueder.bsky.social · May 25

Thank you Luciano!

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Florian Schueder @florianschueder.bsky.social · May 25

Thank you Christophe!

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Florian Schueder @florianschueder.bsky.social · May 25

Thank you Pierre!

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Florian Schueder @florianschueder.bsky.social · May 25

Thank you Nike!

Florian Schueder @florianschueder.bsky.social · May 22

Big news: I’m joining EPFL as Tenure-Track Assistant Professor of Life Science Engineering!
Can’t wait to push super-resolution microscopy & spatial omics even further and build new collaborations in Lausanne. 🚀
#EPFL #SuperResolution #Microscopy #SpatialOmics #DNAPAINT

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Florian Schueder @florianschueder.bsky.social · Jan 16

The Stocker Lab’s Juanita Lara Gutierrez and colleagues discovered a new and highly interesting iron uptake mechanism in bacteria.
www.biorxiv.org/content/10.1...

Growth in Low Carbon Conditions Reveals Amino-Acid-Coupled Iron Uptake

Bacteria in nature encounter substrates at widely varying concentrations, yet studies of bacterial physiology have focused more on nutrient type than concentration, partly due to challenges in maintai...

www.biorxiv.org

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Reposted by Florian Schueder

Richard Sever @richardsever.bsky.social · Dec 24

"You'll be revisited by three spirits"

The spirits:

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Reposted by Florian Schueder

Zach Marin @zacsimile.bsky.social · Dec 24

Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors! www.nature.com/articles/s41...

Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods

The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...

www.nature.com

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Florian Schueder @florianschueder.bsky.social · Dec 16

I am very excited and deeply honored that our most recent work on #FLASHPAINT was highlighted as one of the methods to watch by @naturemethods.bsky.social' @ritastrack.bsky.social in the context of ‘spatial proteomics’ as Nature Methods' Method of the Year 2024. www.nature.com/articles/s41...

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Florian Schueder @florianschueder.bsky.social · Nov 20

Would you mind adding me as well?

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Florian Schueder @florianschueder.bsky.social · Nov 19

Please check out our (@bewersdorflab) latest work on #FLASHPAINT published in @CellCellPress.
#FLASHPAINT builds on #DNAPAINT and allows for fast and fluorogenic, highly multiplexed super-resolution imaging. cell.com/cell/fulltex...

Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging

Development of FLASH-PAINT enables rapid and efficient visualization of cellular organelles, using a potentially unlimited number of labels.

cell.com

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Florian Schueder @florianschueder.bsky.social · Nov 17

Could you add me please?

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