francescachandler.bsky.social
Francesca Chandler
@francescachandler.bsky.social
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francescachandler.bsky.social
Francesca Chandler @francescachandler.bsky.social · Mar 17
Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
www.nature.com
3 16
Reposted by Francesca Chandler
zeqiraj.bsky.social
Elton Zeqiraj @zeqiraj.bsky.social · Mar 17
A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...
Molecular Glues: drugging the undruggable
YouTube video by Phospho Biomedical Animation
youtu.be
1
Reposted by Francesca Chandler
zeqiraj.bsky.social
Elton Zeqiraj @zeqiraj.bsky.social · Mar 17
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF
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francescachandler.bsky.social
Francesca Chandler @francescachandler.bsky.social · Mar 17
Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
www.nature.com
3 16