Lightnews — Scholar-powered news

Reposted by Elton Zeqiraj

Shane Herbert @shaneherbert.bsky.social · May 6

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

www.science.org

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 23

Thanks Malte.

Reposted by Elton Zeqiraj

Richard Bayliss @molecularrichard.bsky.social · Mar 21

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

Structural characterization and inhibition of the interaction between ch-TOG and TACC3 | Journal of Cell Biology | Rockefeller University Press

Shelford, Burgess, and colleagues present a structural model of the interaction between TACC3 and ch-TOG. They discover Affimers that can inhibit this inte

doi.org

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Reposted by Elton Zeqiraj

Komander Lab @komanderlab.bsky.social · Mar 13

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social

Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Reposted by Elton Zeqiraj

Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Reposted by Elton Zeqiraj

Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Mar 18

🔬Sibling rivalry alert!
Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡
Exciting times ahead!

Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌
#cryoEM #cryoET

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 18

Thanks Rune.

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 18

Thanks Kei. Fingers crossed!

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...

Molecular Glues: drugging the undruggable

YouTube video by Phospho Biomedical Animation

youtu.be

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social
@antoncalabrese.bsky.social
@bioscienceleeds.bsky.social

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

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Reposted by Elton Zeqiraj

Francesca Chandler @francescachandler.bsky.social · Mar 17

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

www.nature.com

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Reposted by Elton Zeqiraj

Sakamoto Lab @labsakamoto.bsky.social · Mar 6

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK-inhibitors availab...

www.biorxiv.org

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Reposted by Elton Zeqiraj

Sakamoto Lab @labsakamoto.bsky.social · Feb 27

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex

Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

link.springer.com

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