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Sylvie Callegari

@sylviecallegari.bsky.social

170 followers 170 following 13 posts

Postdoc @Komander lab, WEHI, Melbourne. Mitochondrial biochemist interested in ubiquitin 🤓.

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Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Sylvie Callegari @sylviecallegari.bsky.social · 6d

Really enjoyed the #ASBMB2025 conference in Brisbane this week. It's an honour to get to present to this audience and winning an oral presentation prize was an unexpected bonus!

Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 7d

Congratulations to all our poster and speaker prize winners!! 🏆🏆🏆

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Reposted by Sylvie Callegari

Josh Hardy @joshuamhardy.bsky.social · 10d

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · Sep 3

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

🔗 www.wehi.edu.au/news/eureka-...

📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.

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Reposted by Sylvie Callegari

Marnie Blewitt @marnieblewitt.bsky.social · Sep 3

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

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Brett Collins @brettcollins.bsky.social · Sep 2

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Director, Centre for Chemistry and Drug Discovery

Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...

uq.wd3.myworkdayjobs.com

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 28

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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iubmb.bsky.social @iubmb.bsky.social · Aug 8

Our June Newsletter highlights IUBMB activities including a note from the President and updates on the IUBMB Trainee Initiative

➡️http://bit.ly/45ai6r1

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Reposted by Sylvie Callegari

Australian Museum Eureka Prizes @eurekaprizes.bsky.social · Jul 31

PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research.

Learn more: youtu.be/senXARXzO20

#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social

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Sylvie Callegari @sylviecallegari.bsky.social · Jul 31

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.

Excited for the awards ceremony on Sept 3rd!

@eurekaprizes.bsky.social
@wehi-research.bsky.social

PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research

YouTube video by Australian Museum

www.youtube.com

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Derek Lowe @dereklowe.bsky.social · Jul 30

“Why do we sleep” has been a surprisingly hard question. But it looks like the answer may be “ Because we breathe”. Our mitochondria need a break!

It All Comes Down to the Mitochondria

www.science.org

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Reposted by Sylvie Callegari

Komander Lab @komanderlab.bsky.social · Jul 11

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin

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Rashmi Agrata @rashmiagrata.bsky.social · Jul 4

Australia’s First Ubiquitin Summit is here! 🥳
📍Lorne, Victoria | 🗓️ 20–23 November 2025

Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

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Science Magazine @science.org · May 23

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

Silencing mitochondrial gene expression in living cells

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

scim.ag

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Micha Rapé Lab @micharapelab.bsky.social · May 7

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

Molecular basis of SIFI activity in the integrated stress response - Nature

Nature - Molecular basis of SIFI activity in the integrated stress response

www.nature.com

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Sylvie Callegari @sylviecallegari.bsky.social · May 1

I looked this up for a review I wrote a few years ago. The PNAS paper is definitely one of the first, but there was an earlier version of the in vitro import assay published by the Neupert lab in 1977 pubmed.ncbi.nlm.nih.gov/145943/.

Transport of cytoplasmically synthesized proteins into the mitochondria in a cell free system from Neurospora crassa - PubMed

Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic rib...

pubmed.ncbi.nlm.nih.gov

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Sylvie Callegari @sylviecallegari.bsky.social · Apr 18

Stunning photo of Mars on the cover of Science this week! And super proud that our structure of PINK1 stalled at mitochondrial translocases also gets a cover mention 😊. It's now out in print on page 303!

Science Magazine @science.org · Apr 17

NASA’s Curiosity rover has uncovered a hidden chemical archive of ancient Mars’ atmosphere, which suggests that large amounts of carbon dioxide have been locked into the planet’s crust, according to a new Science study.

Learn more in this week's issue: scim.ag/3Ed9kOl

This photograph of Gale crater, Mars, was taken by the Curiosity rover at the Ubajara drill site. The rover’s 40-cm-wide tracks are visible in the foreground. The rover drilled a rock sample at this location, which was found to contain substantial amounts of siderite, an iron carbonate mineral. The siderite likely played a role in an ancient carbon cycle that affected Mars’ surface climate.

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Komander Lab @komanderlab.bsky.social · Apr 8

Excited to share news from the lab out in Nature Communications – A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
www.nature.com/articles/s41...
@wehi-research.bsky.social

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID - Nature Communications

A novel antiviral targeting the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides proof-of-principle that P...

www.nature.com

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Komander Lab @komanderlab.bsky.social · Apr 7

Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org

And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org

See you there!

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Cooty McCootFace @cootymccootface.bsky.social · Mar 15

Human PINK1 at a TOM-VDADC array
Structure of the Week/Month/Year(?)! 9eih.
Sylvia Callegari...David Komander, Science 13 March 2025.
#coot Fancy mode
Copyright/license-free - i.e. freely reproducible.
Coot 1.1.14 coming soon!

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Jim Hurley @jimhurley.bsky.social · Mar 25

PINK1/Parkin-dependent mitophagy caught in situ by cryo-ET! New preprint www.biorxiv.org/content/10.1... led by @kev-in-situ-et.bsky.social. This has been a long-standing goal of team @mito911.bsky.social within the @asapresearch.parkinsonsroadmap.org initiative.

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Sylvie Callegari @sylviecallegari.bsky.social · Mar 22

Thanks Malte!

Reposted by Sylvie Callegari

Florent Waltz @florentwaltz.bsky.social · Mar 21

I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?

Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

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Ben Engel @cellarchlab.com · Mar 20

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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Sylvie Callegari @sylviecallegari.bsky.social · Mar 15

Thanks Brett 😊

Sylvie Callegari @sylviecallegari.bsky.social · Mar 15

Thank you Sharad!