Lightnews — Scholar-powered news

Micha Rapé Lab @micharapelab.bsky.social · 27d

Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social

www.sciencedirect.com/science/arti...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

www.sciencedirect.com

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Reposted by Micha Rapé Lab

James Olzmann @olzmannlab.bsky.social · Aug 21

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098

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Micha Rapé Lab @micharapelab.bsky.social · Aug 21

Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!

aprecruit.berkeley.edu/JPF05098

Assistant Professor -Molecular Therapeutics - Molecular and Cell Biology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

Reposted by Micha Rapé Lab

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jul 29

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

“Revolutionary Science Comes from Unexpected Angles”

magazine.hms.harvard.edu

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Reposted by Micha Rapé Lab

UC Berkeley @ucberkeleyofficial.bsky.social · Jul 1

UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...

UC Berkeley research builds a better tomorrow

YouTube video by UC Berkeley

youtu.be

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Reposted by Micha Rapé Lab

berkeleyMCB @berkeleymcb.bsky.social · Jun 25

Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...

Jane Coffin Childs Fellows Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab)

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Micha Rapé Lab @micharapelab.bsky.social · Jun 24

Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang!

www.jccfund.org/wp-content/u...

www.jccfund.org

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Micha Rapé Lab @micharapelab.bsky.social · Jun 15

Thank you to Sara Osman for highlighting our recent SIFI work!

www.nature.com/articles/s41...

Better SIFI than sorry - Nature Structural & Molecular Biology

Nature Structural & Molecular Biology - Better SIFI than sorry

www.nature.com

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Micha Rapé Lab @micharapelab.bsky.social · Jun 8

Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social

Molecular Therapeutics Initiative @mti-ucb.bsky.social · Jun 8

Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen.
#MTI #Amgen #Biotech #UCB

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Micha Rapé Lab @micharapelab.bsky.social · May 29

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

James Olzmann @olzmannlab.bsky.social · May 29

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
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Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

www.pnas.org

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Micha Rapé Lab @micharapelab.bsky.social · May 24

But please do not compare the pictures from the last 78 commencements we attended ;-)

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Micha Rapé Lab @micharapelab.bsky.social · May 24

Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!

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Micha Rapé Lab @micharapelab.bsky.social · May 20

Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!

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Micha Rapé Lab @micharapelab.bsky.social · May 15

Congratulations to #MolecularTherapeutics faculty and
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!

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Reposted by Micha Rapé Lab

Molecular Therapeutics Initiative @mti-ucb.bsky.social · May 9

🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee!
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth

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Micha Rapé Lab @micharapelab.bsky.social · May 8

Thank you Jonathan!

Micha Rapé Lab @micharapelab.bsky.social · May 8

Thank you Roberto!

Micha Rapé Lab @micharapelab.bsky.social · May 7

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

Molecular basis of SIFI activity in the integrated stress response - Nature

Nature - Molecular basis of SIFI activity in the integrated stress response

www.nature.com

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Reposted by Micha Rapé Lab

Molecular Therapeutics Initiative @mti-ucb.bsky.social · May 3

🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee!

His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.

A new era of brain-targeted molecular therapeutics.

#MTI #Neurobiology #FRET

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Micha Rapé Lab @micharapelab.bsky.social · May 2

Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!

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Micha Rapé Lab @micharapelab.bsky.social · Apr 29

Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis!

news.berkeley.edu/2025/04/22/t...

Two Berkeley professors receive prestigious Guggenheim fellowships - Berkeley News

Philosopher Hannah Ginsborg will use the award to write a book about the relation between norms and reasons, while chemical engineer Markita del Carpio Landry will try to find molecules in little-stud...

news.berkeley.edu

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Micha Rapé Lab @micharapelab.bsky.social · Apr 26

Congratulations!

Molecular Therapeutics Initiative @mti-ucb.bsky.social · Apr 25

🧬 Announcing the 2025 Innovator Awardees!
Proud to support 6 researchers with $90K + resources.

🔬Lareau: CRISPR for retinitis pigmentosa
🧪Hurley: Cancer inhibitors
✨Sherriff & Olzmann: Molecular glues
🥼Welch: Sleeping sickness
🧫Isacoff: Fast-acting antidepressants

Advancing innovation at Berkeley

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Micha Rapé Lab @micharapelab.bsky.social · Apr 24

Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!

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Micha Rapé Lab @micharapelab.bsky.social · Apr 23

Congratulations Ashley and Roberto and team!

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Micha Rapé Lab @micharapelab.bsky.social · Apr 23

New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!

The EMBO Journal @embojournal.org · Apr 22

AKAP11 recruits PKA holoenzymes to #autophagosomes in a bidirectional functional association, both promoting downstream PKA signaling and increasing AKAP11-PKA complex degradation
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....

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