Lightnews — Scholar-powered news

Reposted by Rashmi Agrata

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · Sep 3

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

🔗 www.wehi.edu.au/news/eureka-...

📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.

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Rashmi Agrata @rashmiagrata.bsky.social · Aug 29

Beautiful read and great work! Congratulations, Dan!

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Rashmi Agrata @rashmiagrata.bsky.social · Jul 4

🌿 While you're here, explore Australia’s unique biodiversity—and make the most of your trip by attending the 11th International Symposium on Autophagy at the same venue, just before the summit: 16–20 November 2025. Register: www.isa11.org

11th International Symposium on Autophagy

www.isa11.org

Rashmi Agrata @rashmiagrata.bsky.social · Jul 4

🌏 Be part of the first-ever ubiquitin-focused meeting in the Southern Hemisphere.

🔗 Register: lnkd.in/g4pXHFmH
🕒 Abstract submission deadline: 18 July 2025

@komanderlab.bsky.social @wehi-research.bsky.social

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Rashmi Agrata @rashmiagrata.bsky.social · Jul 4

Australia’s First Ubiquitin Summit is here! 🥳
📍Lorne, Victoria | 🗓️ 20–23 November 2025

Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

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Thanh Nguyen @thanhrnguyen.bsky.social · May 31

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

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Komander Lab @komanderlab.bsky.social · Apr 8

Excited to share news from the lab out in Nature Communications – A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
www.nature.com/articles/s41...
@wehi-research.bsky.social

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID - Nature Communications

A novel antiviral targeting the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides proof-of-principle that P...

www.nature.com

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Reposted by Rashmi Agrata

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 9

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪

Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction.

Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213

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Reposted by Rashmi Agrata

Komander Lab @komanderlab.bsky.social · Apr 7

Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org

And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org

See you there!

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Rashmi Agrata @rashmiagrata.bsky.social · Mar 24

Congratulations Leo, this is so cool! Excited to see new avenues this will open up.

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Marco Trujillo @trujillolab.bsky.social · Mar 13

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis
www.nature.com/articles/s41...

Perception of viral infections and initiation of antiviral defence in rice - Nature

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

www.nature.com

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Komander Lab @komanderlab.bsky.social · Mar 13

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social

Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Pratik Kumar @dyechemist.bsky.social · Mar 12

Come and do some chemistry for biology with us!

National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · Mar 11

#NewFaculty
Welcome to the campus Dr Pratik!
Dr Pratik is a 'tool builder' working at the intersection of Biology and chemistry.
We look forward to the contributions from his lab.
Know more: news.ncbs.res.in/spotlight/nc...

@dyechemist.bsky.social

🖊️@rupsykhurana.bsky.social

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Clausen Lab @clausenlab.bsky.social · Mar 4

DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...

A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode

Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle m…

www.sciencedirect.com

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Pratik Kumar @dyechemist.bsky.social · Feb 28

If making chemical tools for biology excites you, consider applying to the NCBS graduate program! My lab plans to hire 1–2 graduate students this cycle. More info on my lab @ dyecraftlab.com

National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · Feb 26

#AdmissionsAlert!
The National Centre for Biological Sciences announces the opening of online applications for admission to its PhD programme through National Exam Route.

Application Deadline: 24th March 2025
Joining: 1st August 2025

Apply here: bit.ly/4igBGFK

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 6

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Feb 6

There are lots of hydrophobicity scales and perhaps the most well known and used is that from Kyte & Doolittle

If you ever use that scale, I recommend reading the original paper and noting the authors' pragmatism and honesty about manual adjustments and using intuition

doi.org/10.1016/0022...

Text from the paper discussing various manual adjustments and choices of the hydrophobicity scale

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jan 31

The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution

Thanks for coming to my TED talk

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GRK2243 @grk2243.bsky.social · Jan 27

🚨 The #Ubiquitin Congress is back in Würzburg! 🚨
Excited to host it again, June 2-4, 2025! 🌟

✨ Still time to submit your abstract for a Short Talk!

🗓️ Registration Deadline: March 1st
📝 Abstract Submission Deadline: April 15th

Don’t miss out—register now!
➡️ www.ubiquitin-wuerzburg-2025.de

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Sjors Scheres @sjorsscheres.bsky.social · Jan 27

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196

Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

www.nature.com

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Rashmi Agrata @rashmiagrata.bsky.social · Jan 20

Thanks for the kind words, Jane!

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Reposted by Rashmi Agrata

Jane Dudley @janedudley.bsky.social · Jan 20

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

Ubiquitin—A structural perspective

Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...

www.cell.com

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Rashmi Agrata @rashmiagrata.bsky.social · Jan 17

Hi,
Glad to hear your interest. The link to the free-version (for 50 days) is here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Perks: you can see a video of all the diUb conformations in this link.
for the PDF, please DM
DOI for future reference: doi.org/10.1016/j.mo...

kwnsfk27.r.eu-west-1.awstrack.me

Reposted by Rashmi Agrata

Aniruddha Das @aniruddhad.bsky.social · Jan 17

"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.

www.cell.com/molecular-ce...

Ubiquitin—A structural perspective

Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...

www.cell.com

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