Lightnews — Scholar-powered news

Marco Trujillo @trujillolab.bsky.social · 1d

Thank you so much Andreas! It is indeed!

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Marco Trujillo @trujillolab.bsky.social · 1d

Thanks!

Marco Trujillo @trujillolab.bsky.social · 1d

Hey Sjon, thanks! Now it will be more difficult to drop by though ;)

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Marco Trujillo @trujillolab.bsky.social · 1d

Hey Tim, thanks a lot! Looking forward to insider tips 😉

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Marco Trujillo @trujillolab.bsky.social · 1d

Excited to join the Nordinfect meeting on #infection #inflamation and #immunology. Great chance to meet the community #NDI3
@fzborstel.bsky.social

ndi3.fz-borstel.de?trk=public_p...

NDI3 - New Developments in Immunology, Inflammation and Infection

The NDI³ is a scientific conference standing for New Developments in Immunology, Inflammation and Infection.

ndi3.fz-borstel.de

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Marco Trujillo @trujillolab.bsky.social · 1d

Thank you Greg!

Marco Trujillo @trujillolab.bsky.social · 1d

Thanks so much Yasi!

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Marco Trujillo @trujillolab.bsky.social · 1d

Thank you Freddie!

Marco Trujillo @trujillolab.bsky.social · 1d

Thank you Jürgen! Will do!

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Marco Trujillo @trujillolab.bsky.social · 2d

Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg

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Reposted by Marco Trujillo

Karla Feijs-Žaja @kfeijszaja.bsky.social · Apr 25

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???

Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

Mike Cohen @michaelnadbio.bsky.social · Apr 24

Thanks @kfeijszaja.bsky.social and team for the excellent Spotlight on our collaborative work with @jnpruneda.bsky.social: Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells: Trends in Biochemical Sciences www.cell.com/trends/bioch...

Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells

Ubiquitination and ADP-ribosylation are protein post-translational modifications (PTMs) which influence diverse protein properties. In vitro work has indicated that ubiquitin can be ADP-ribosylated an...

www.cell.com

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Reposted by Marco Trujillo

Rune Busk Damgaard @rbdamgaard.bsky.social · Apr 22

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

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Reposted by Marco Trujillo

Michelle Frei @michellefrei17.bsky.social · Apr 21

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

www.nature.com

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Reposted by Marco Trujillo

Jane Dudley @janedudley.bsky.social · Apr 11

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

rdcu.be

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Marco Trujillo @trujillolab.bsky.social · Apr 11

Amazing !! Antiproteolysis peptides (APPs), identified by artificial intelligence, stabilized TF by inhibiting E3 ligase to induce resistance. Targeted Inhibition of Protein Degradation #TIPD #PPSTasis www.science.org/doi/10.1126/...
Commentary www.science.org/doi/10.1126/...

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Reposted by Marco Trujillo

Lechtenberg Lab @lechtenberglab.bsky.social · Apr 10

Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.

Life Science Alliance @lsajournal.org · Apr 2

The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination
@lechtenberglab.bsky.social @wehi-research.bsky.social
www.life-science-alliance.org/content/8/6/...

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Reposted by Marco Trujillo

Pam Ronald @pcronald.bsky.social · Apr 10

www.ft.com/content/6328... Greenpeace has blocked
cultivation of Golden Rice braking an innovation slated to
save lives by enriching diets w/ vitamin A. In a world
beset by food insecurity,climate change,water scarcity &
conflict,the future of rice is
mired in a stew of science, politics & economics

We face a looming rice crisis

The future of one of the world’s most important foodstuffs is mired in a stew of science, politics and economics

www.ft.com

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Marco Trujillo @trujillolab.bsky.social · Apr 10

Great Review on TOR signalling: A Master Regulator in Plant Growth, Development, and Stress Responses #PPStasis #proteostasis #autophagy #Stressbio #Plantsci
www.annualreviews.org/content/jour...

Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses | Annual Reviews

The target of rapamycin (TOR) is a central regulator of growth, development, and stress adaptation in plants. This review delves into the molecular intricacies of TOR signaling, highlighting its conse...

www.annualreviews.org

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Reposted by Marco Trujillo

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 9

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪

Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction.

Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213

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Reposted by Marco Trujillo

Anthony Leung @leunglab.bsky.social · Apr 8

🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal

imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...

www.embopress.org

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Reposted by Marco Trujillo

Thomas Arnesen @natmachinery.bsky.social · Apr 3

Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...

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Reposted by Marco Trujillo

Yasin Dagdas @plantophagy.bsky.social · Apr 3

#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”

two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '

ALT: two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '

media.tenor.com

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Reposted by Marco Trujillo

Maddy Seale @maddyseale.bsky.social · Mar 30

2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

#PlantScience

A wheat tandem kinase activates an NLR to trigger immunity

The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and ba...

www.science.org

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Reposted by Marco Trujillo

Micha Rapé Lab @micharapelab.bsky.social · Mar 27

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!!

www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Reposted by Marco Trujillo

Leo Kiss @leokiss.bsky.social · Mar 24

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

www.cell.com

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