Mike Cohen
@michaelnadbio.bsky.social
Chemical biologist passionate about post-translational modifications (PTMs) and a keen interest in drug development. Professor at OHSU leading a team dedicated to unraveling the mysteries of PARPs and ADP-ribosylation.
Reposted by Mike Cohen
I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies
across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2)
and checkpoint (ATR-CHK1) kinases t...
www.cell.com
February 4, 2026 at 4:06 PM
I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Reposted by Mike Cohen
Registration deadline extended to January 31, 2026. Join us @nucleosomepolice.bsky.social @leunglab.bsky.social at CSHL for the PARP Meeting—connect with leaders and rising stars from academia and industry. Please kindly repost!
.https://meetings.cshl.edu/meetings.aspx?meet=parp
.https://meetings.cshl.edu/meetings.aspx?meet=parp
The PARP Family & ADP-ribosylation
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 21, 2026 at 4:44 PM
Registration deadline extended to January 31, 2026. Join us @nucleosomepolice.bsky.social @leunglab.bsky.social at CSHL for the PARP Meeting—connect with leaders and rising stars from academia and industry. Please kindly repost!
.https://meetings.cshl.edu/meetings.aspx?meet=parp
.https://meetings.cshl.edu/meetings.aspx?meet=parp
Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.
Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...
The PARP Family & ADP-ribosylation
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 21, 2026 at 6:14 PM
Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.
Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...
The PARP Family & ADP-ribosylation
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 15, 2026 at 4:02 AM
Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...
Reposted by Mike Cohen
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
www.biorxiv.org
January 6, 2026 at 3:40 PM
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Mike Cohen
New work from my team, identifying drug targets in M. abscessus. Pre-print posted here:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Chemoproteomic elucidation of β-lactam drug targets in Mycobacterium abscessus
The pathogen Mycobacterium abscessus ( Mab ) can cause severe and difficult to treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are...
www.biorxiv.org
December 17, 2025 at 1:15 AM
New work from my team, identifying drug targets in M. abscessus. Pre-print posted here:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Looking forward to the biannual #CBP2025 conference @ohsunews.bsky.social starting this week! incredible line up of speakers, including keynotes @mbogyo.bsky.social, @christhechang.bsky.social, and Nancy Carrasco.
www.ohsu.edu/school-of-me...
www.ohsu.edu/school-of-me...
Chemical Biology and Physiology 2025 | OHSU
Chemical Biology and Physiology Conference 2025, December 11-13, 2025
www.ohsu.edu
December 7, 2025 at 2:16 PM
Looking forward to the biannual #CBP2025 conference @ohsunews.bsky.social starting this week! incredible line up of speakers, including keynotes @mbogyo.bsky.social, @christhechang.bsky.social, and Nancy Carrasco.
www.ohsu.edu/school-of-me...
www.ohsu.edu/school-of-me...
Excellent study by first author @andriigorelik.bsky.social in @ahellab.bsky.social showing how DTX2 tunes AHR transcription and stability, offering deeper insight into ADP-ribosylation–ubiquitylation crosstalk.
In our latest study we show that ligand-activated transcription factor AHR (environmental sensor) is ADP-ribosylated by PARP7. This ADP-ribose mark is recognised by the E3 ubiquitin ligase DTX2 targeting AHR for proteasomal degradation, enabling cells to rapidly shut down AHR-mediated transcription.
Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation | The EMBO Journal
imageimageDegradation mechanisms of transcriptionally active aryl hydrocarbon receptor (AHR)
are unclear. This work reveals that PARP7 ADP-ribosylates itself and ligand-bound
AHR, creating a recogniti...
www.embopress.org
December 2, 2025 at 2:57 PM
Excellent study by first author @andriigorelik.bsky.social in @ahellab.bsky.social showing how DTX2 tunes AHR transcription and stability, offering deeper insight into ADP-ribosylation–ubiquitylation crosstalk.
Talazoparib stands out for its strong potency and DNA "trapping" in certain cancers, but why this happens wasn’t clear. A new preprint from first author Jin Cai in the @ladurner.bsky.social lab, together with Ben Black’s team, address this in a new preprint: www.biorxiv.org/content/10.1...
November 13, 2025 at 6:42 PM
Talazoparib stands out for its strong potency and DNA "trapping" in certain cancers, but why this happens wasn’t clear. A new preprint from first author Jin Cai in the @ladurner.bsky.social lab, together with Ben Black’s team, address this in a new preprint: www.biorxiv.org/content/10.1...
Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
November 11, 2025 at 4:21 PM
Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!
Reposted by Mike Cohen
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
October 30, 2025 at 3:33 PM
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Mike Cohen
My quote of the day
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
July 17, 2025 at 10:44 AM
My quote of the day
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
Reposted by Mike Cohen
'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...
www.nytimes.com/2025/07/10/s...
Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows
www.nytimes.com
July 13, 2025 at 8:05 AM
'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...
www.nytimes.com/2025/07/10/s...
Reposted by Mike Cohen
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 6:11 AM
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Reposted by Mike Cohen
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 10:44 AM
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 9, 2025 at 4:15 PM
Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.
Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.
July 7, 2025 at 6:46 PM
Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.
Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!
Our review on kidney sensory innervation is out! It was such an honor to write about all the amazing work from my colleagues in this growing field of renal interoception. Yay kidneys! www.sciencedirect.com/science/arti...
July 3, 2025 at 3:48 AM
Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!
💯 👇!
Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!
June 22, 2025 at 6:01 PM
💯 👇!
Reposted by Mike Cohen
Today they have crossed a deep red line.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
June 12, 2025 at 8:05 PM
Today they have crossed a deep red line.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS
PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety
onto proteins related to immunity, transcription, and cell g...
www.pnas.org
June 12, 2025 at 7:08 PM
Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.
Reposted by Mike Cohen
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
June 9, 2025 at 3:33 PM
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!
June 8, 2025 at 4:08 PM
@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!
Reposted by Mike Cohen
Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
June 8, 2025 at 12:21 AM
Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!
Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
www.biorxiv.org
June 4, 2025 at 11:26 PM
Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!