Karolin Luger
@nucleosomepolice.bsky.social
Chromatin and cryoEM afficionada. Still a fan of crystallography. Avid Colorado hiker. Will call out ugly nucleosome cartoons. Come for the science, stay for the mountain pictures and snark. Opinions and snark are my own.
Pinned
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Reposted by Karolin Luger
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
November 26, 2025 at 5:12 PM
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
Reposted by Karolin Luger
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
November 26, 2025 at 4:00 PM
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Will you look at this. The world is shite but then there are azalea...
November 27, 2025 at 3:22 AM
Will you look at this. The world is shite but then there are azalea...
i'd gladly wear nice clothes when flying if airplanes werent as filthy and crowded. As long as there is a high probability that I sit in a seat where somebody has parked their street shoes, and my neighbor who sits 1 inch away from me spills their OJ on me, i wont put on my finery.
Sorry, Sean Duffy, the age of suits was not the golden age of airplane civility. To restore order in the skies, we need to look even further back, @petridishes.bsky.social writes:
The Biggest Problem With Air Travel: Pajamas?
The transportation secretary seems to think fashion will solve flying’s problems.
bit.ly
November 26, 2025 at 11:29 PM
i'd gladly wear nice clothes when flying if airplanes werent as filthy and crowded. As long as there is a high probability that I sit in a seat where somebody has parked their street shoes, and my neighbor who sits 1 inch away from me spills their OJ on me, i wont put on my finery.
this illustration is rad
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 10:09 PM
this illustration is rad
Reposted by Karolin Luger
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Postdoctoral Fellow - H Yardimci Lab
www.crick.ac.uk
November 25, 2025 at 11:55 AM
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Reposted by Karolin Luger
The Richard and Susan Smith Family Foundation, which supports our work, has produced a short film about our research:
November 26, 2025 at 1:22 AM
The Richard and Susan Smith Family Foundation, which supports our work, has produced a short film about our research:
#dontlookup. or down, or anywhere. just get your #blackfriday shopping done and eat your butterball turkey. nothing to see here.
At present the issue is how to reinforce existing infrastructure or fortify shoreline, or relocate, Indigenous villages. In future decades major coastal cities around the world will face the same dilemma. Metres of sea-level rise are committed, even if we succeed in reaching net zero.
Storms that battered Alaska’s western coast this fall have brought renewed attention to low-lying Indigenous villages left increasingly vulnerable by climate change.
November 25, 2025 at 8:40 PM
#dontlookup. or down, or anywhere. just get your #blackfriday shopping done and eat your butterball turkey. nothing to see here.
👇👇👇
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
November 25, 2025 at 5:40 PM
👇👇👇
I cannot unsee this
I don't think this AI-generated "crocheted nucleosome" would fool the nucleosome police...
November 25, 2025 at 12:29 AM
I cannot unsee this
say what now?
AI has been infiltrating knitting and crochet spaces, filling them with useless patterns. Here's why that's happening and what can be done about it.
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
The AI Invasion of Knitting and Crochet
AI has been infiltrating knitting and crochet spaces, filling them with useless patterns. Here’s why that’s happening and what can be done about it.
www.plagiarismtoday.com
November 24, 2025 at 9:33 PM
say what now?
Reposted by Karolin Luger
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
November 24, 2025 at 3:17 PM
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
Reposted by Karolin Luger
It’s time for Austria’s Krampus Parades 🖤
November 23, 2025 at 11:08 PM
It’s time for Austria’s Krampus Parades 🖤
OMG this is amazing.
Weird word of the day: "kleptosquamy." The testate amoeba Awerintzewia cyclostoma steals scales from other amoeboid organisms to build its own shell. This one has robbed Quadrulella, Netzelia, various euglyphids, and even an Acanthocystis. Kleptosquamy! #amoebae #ProtistsOnSky #biology #nature
November 22, 2025 at 2:06 PM
OMG this is amazing.
Reposted by Karolin Luger
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 18, 2025 at 2:44 PM
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Reposted by Karolin Luger
College Gate, an Anchorage elementary school with a Yup’ik language immersion program, has taken in more than 80 students from Western Alaska communities.
Anchorage schools welcome students displaced by Typhoon Halong
College Gate, an Anchorage elementary school with a Yup’ik language immersion program, has taken in more than 80 students from Western Alaska communities.
www.adn.com
November 21, 2025 at 3:06 AM
College Gate, an Anchorage elementary school with a Yup’ik language immersion program, has taken in more than 80 students from Western Alaska communities.
oh boy!
November 21, 2025 at 1:06 PM
oh boy!
been using #LLM quite a bit to check up on facts for my class that I did kind of sort of knew the answer to, but wanted to verify, and boyo is it hit or miss. More miss. also, whats up with the obsequiousness? If you dont know just fess up!
November 21, 2025 at 12:35 PM
been using #LLM quite a bit to check up on facts for my class that I did kind of sort of knew the answer to, but wanted to verify, and boyo is it hit or miss. More miss. also, whats up with the obsequiousness? If you dont know just fess up!
exact same question
People who ride scooters: do yall just Rapture off the things when you get to your destination? Because wtf is this?
November 20, 2025 at 10:34 PM
exact same question
Reposted by Karolin Luger
Opuntia phaeacantha, our Brown-spined Pricklypear, blooming above the Dolores River #nativeplants
#FallbackFlowers #Fallback to May 20 🌿
#FallbackFlowers #Fallback to May 20 🌿
November 20, 2025 at 4:00 PM
Opuntia phaeacantha, our Brown-spined Pricklypear, blooming above the Dolores River #nativeplants
#FallbackFlowers #Fallback to May 20 🌿
#FallbackFlowers #Fallback to May 20 🌿
thats so on point!
My favorite ever letter of recommendation is one Ficino wrote in the late 1500s, recommending a pupil for a secretary job with King Matthias Corvinus of Hungary, in which he says the young man is “the reincarnation of Saint Thomas Aquinas.”
It’s letter-of-recommendation season again, when universities ask me to rate a 21 year old student’s ability to “see the big picture of life” while I eat leftover pasta in a Tupperware…
November 19, 2025 at 7:18 PM
thats so on point!
www.nytimes.com/2025/11/19/o...
sharing this with y'all.
sharing this with y'all.
Opinion | The White House Gold Rush Is On
www.nytimes.com
November 19, 2025 at 1:11 PM
www.nytimes.com/2025/11/19/o...
sharing this with y'all.
sharing this with y'all.
Reposted by Karolin Luger
New paper alert ! 🙂
Happy to share our new study published in The Cryosphere !
doi.org/10.5194/tc-1...
We modelled the evolution of the Greenland Ice Sheet from the LGM (24 ka) to the present and learned a lot on its former history and dynamics !
@jeremyely.bsky.social @chrisdclark.bsky.social
Happy to share our new study published in The Cryosphere !
doi.org/10.5194/tc-1...
We modelled the evolution of the Greenland Ice Sheet from the LGM (24 ka) to the present and learned a lot on its former history and dynamics !
@jeremyely.bsky.social @chrisdclark.bsky.social
November 18, 2025 at 2:35 PM
New paper alert ! 🙂
Happy to share our new study published in The Cryosphere !
doi.org/10.5194/tc-1...
We modelled the evolution of the Greenland Ice Sheet from the LGM (24 ka) to the present and learned a lot on its former history and dynamics !
@jeremyely.bsky.social @chrisdclark.bsky.social
Happy to share our new study published in The Cryosphere !
doi.org/10.5194/tc-1...
We modelled the evolution of the Greenland Ice Sheet from the LGM (24 ka) to the present and learned a lot on its former history and dynamics !
@jeremyely.bsky.social @chrisdclark.bsky.social
totally normal stuff.
you don't have to embarrass our guest by asking if he had someone killed and hacked to pieces
Trump suggests Khashoggi had it coming: "You're mentioning someone that was extremely controversial. A lot of people didn't like that gentleman that you're talking about. Whether you like him or didn't like him, things happen. But he knew nothing about it. You don't have to embarrass our guest."
November 18, 2025 at 8:17 PM
totally normal stuff.