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Reposted by Hasan Yardimci

Aga Gambus @agagambus.bsky.social · 4d

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

Senior Research Technician at University of Birmingham

Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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Reposted by Hasan Yardimci

puckknipscheer.bsky.social @puckknipscheer.bsky.social · 22d

Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs

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Reposted by Hasan Yardimci

Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Reposted by Hasan Yardimci

Hana Polasek-Sedlackova @hanasedlackova.bsky.social · Jul 23

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @jcb.org! Full link here: rupress.org/jcb/article-...

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Reposted by Hasan Yardimci

Journal of Cell Biology @jcb.org · Jul 16

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

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Hasan Yardimci @hyardimci.bsky.social · Jul 9

Thanks Gideon!

Reposted by Hasan Yardimci

The Francis Crick Institute @crick.ac.uk · Jul 9

Congratulations to @hyardimci.bsky.social on receiving a £2.3m @wellcometrust.bsky.social Discovery Award to study how cells faithfully duplicate their genetic material when under stress. 🥳

www.crick.ac.uk/news-and-fea...

£2.3m awarded to study DNA replication stress

Hasan Yardimci, Senior Group Leader at the Francis Crick Institute, has received a Wellcome Discovery Award for £2.3m to study how cells faithfully duplicate their genetic material when under stress.

www.crick.ac.uk

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Reposted by Hasan Yardimci

puckknipscheer.bsky.social @puckknipscheer.bsky.social · Jun 13

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

www.science.org

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David Balchin @davidbalchin.bsky.social · Jun 2

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...

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Reposted by Hasan Yardimci

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Reposted by Hasan Yardimci

Beat Fierz @beatfierz.bsky.social · May 21

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

www.science.org

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Reposted by Hasan Yardimci

Deegan Lab @deeganlab.bsky.social · May 12

Application deadline is this Friday!

Deegan Lab @deeganlab.bsky.social · Apr 15

Exciting opportunity to join us as a PhD student and kickstart cryo-EM studies in our group 🔬🧬. Includes world class training opportunities @mdc-berlin.bsky.social and @uoe-igc.bsky.social. See below for more details and please get in touch if you're interested.

www.findaphd.com/phds/project...

Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Structures and mechanisms of genome replication at University of Edinburgh on FindAPhD.com

PhD Project - Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Structures and mechanisms of genome replication at University of Edinburgh, listed on FindAPhD.com

www.findaphd.com

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Reposted by Hasan Yardimci

Deegan Lab @deeganlab.bsky.social · Apr 15

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.biochemistry.org/events-and-t...

UK DNA Replication Meeting 2026

Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...

www.biochemistry.org

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Reposted by Hasan Yardimci

Hana Polasek-Sedlackova @hanasedlackova.bsky.social · Mar 30

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

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Reposted by Hasan Yardimci

James Briscoe @jamesbriscoe.bsky.social · Mar 13

Science under siege: protecting scientific progress in turbulent times

journals.biologists.com/dev/article/...

Science under siege: protecting scientific progress in turbulent times

As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

journals.biologists.com

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Reposted by Hasan Yardimci

James Dewar @jamesmdewar.bsky.social · Mar 10

🧬⛓️‍ Our latest preprint examines the fate of collapsed forks in vertebrates 🐸 and our colleagues in @heathmurraylab.bsky.social asked similar questions in bacteria 🦠 to reveal how evolution shapes the response to fork collapse (see🧵)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...

Resolution of collapsed forks is separate from completion of DNA synthesis

Replication fork collapse at single-strand DNA breaks (SSBs) poses a serious threat to genome stability. Using Xenopus egg extracts, we show that a replication fork encountering an SSB on either the l...

www.biorxiv.org

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Reposted by Hasan Yardimci

Dirk Remus @dirkremus.bsky.social · Mar 6

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

www.science.org

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Hasan Yardimci @hyardimci.bsky.social · Mar 7

In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here:
www.biorxiv.org/content/10.1...

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Hasan Yardimci @hyardimci.bsky.social · Mar 4

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March:

www.crick.ac.uk/careers-stud...

Yardimci Lab | Single-molecule visualisation of the eukaryotic replication machinery

www.crick.ac.uk

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Anja Groth @groth-anja.bsky.social · Feb 26

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.

Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

DNA replication and genome maintenance: from basic biology to disease

www.embl.org

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Ernst Schmid @ernstschmid.bsky.social · Feb 26

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...

www.cell.com

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Reposted by Hasan Yardimci

The Francis Crick Institute @crick.ac.uk · Feb 20

Our spring round of PhD recruitment is now open!

We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science.

Find out more and apply by midday, 19 March:

www.crick.ac.uk/careers-stud...

PhD student recruitment

2025 PhD recruitment is now open!

www.crick.ac.uk

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Reposted by Hasan Yardimci

Deegan Lab @deeganlab.bsky.social · Feb 7

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection!

institute-genetics-cancer.ed.ac.uk/igc-graduate...

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Reposted by Hasan Yardimci

Erin E. Cutts @eecutts.bsky.social · Dec 16

Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at [email protected]
For details on how to apply: www.findaphd.com/phds/project...

Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield on FindAPhD.com

PhD Project - Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield, listed on FindAPhD.com

www.findaphd.com

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Nynke Dekker Lab @nynkedekkerlab.bsky.social · Dec 12

Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025!

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