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Reposted by Aaron and the Hoskins Lab at UW Madison

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 1h

Today's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future.
asbmb.org/membership

Eleven members of the ASBMB Membership Committee smile and pose for a group photo at ASBMB's offices. They are standing in front of a bookcase lined with issues of the Journal of Biological Chemistry.

Members of the ASBMB Membership Committee gather around a member who is holding a copy of the first issue of the Journal of Biological Chemistry, which was published in Oct. 1905. They issue of the journal is opened and two members are taking photos on their phones.

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 41m

Really interesting paper on the antimalarial impact of inhibition of the presumptive (?) parasite PRP4 kinase involved in splicing

www.biorxiv.org/content/10.1...

Inhibition of PfCLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malaria

Emerging resistance to front-line anti-malarials means there is a race to discover new drugs with novel mechanisms of action that remain effective across multiple stages of the parasite life cycle. Pr...

www.biorxiv.org

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 43m

New from Tim Graubert's and Matt Walter's groups on splicing factor mutations in cancer

www.biorxiv.org/content/10.1...

Sensitivity to ATR-CHK1 pathway inhibition in AML/MDS is enhanced by SRSF2 mutations and reduced by RUNX1 loss

SRSF2 mutations occur in up to 25% of acute myeloid leukemia (AML) and 17% of myelodysplastic syndrome (MDS) cases and are associated with poor prognosis, yet no mutation-directed therapy exists. Here...

www.biorxiv.org

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Reposted by Aaron and the Hoskins Lab at UW Madison

RNA Society @rnasociety.bsky.social · 8d

We are delighted to announce our next RNA Society Member Spotlight!
www.rnasociety.org/joel-mcmanus...

Dr. Joel McManus @mcmanuslabrna.bsky.social is an Associate Professor of Biological Sciences at Carnegie Mellon University in Pittsburgh, USA.

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 2d

Congratulations Andy!

Andy DeLaitsch @delaitsch.bsky.social · 3d

There's a new best-in-class HIV-1 antibody out today! Happy to have contributed to the structural characterization of this, and two other distinct VRC01-class bNAbs isolated from a single individual. www.nature.com/articles/s41...

a, Schematics illustrating the position and length of FWRH1 and/or FWRH3 insertions of 04_A06 (left), 01_D03 (middle) and 05_B08 (right; top), EM maps showing side views of 04_A06, 01_D03 and 05_B08 bnAb Fabs in complex with BG505SOSIP.664 Env trimers (middle) and insets illustrating a close-up of bnAb interactions with the adjacent gp120 protomer (gp1202; bottom); HC, heavy chain; LC, light chain. b, Canonical interactions of CD4 and bnAbs to the CD4bs (04_A06, IOMA and VRC01) with Env gp120 D368, the F43 pocket and gp120 N280/R456. c, Interactions between the CDRH1s of 04_A06 (blue cartoon representation) and 1-18 (red cartoon representation) with the secondary (gp1202) Env protomer, shown as a surface colored by percent conservation. The inset (top right) shows the Env trimer–04_A06 complex as a surface representation for orientation. d, Crystal structure of unbound 04_A06 Fab (bottom) and inset highlighting the 04_A06 CDRH1, with electron density contoured at 1.5σ (top). e, Molecular surface representation showing the surface area buried by VRC01-class bnAbs (04_A06, 01_D03, 05_08, 3BNC117 and VRC01) on primary (gp1201) or secondary (gp1202) Env protomers (top). Listing of Protein Data Bank (PDB) accession codes, breadth (%), heavy chain insertion length and position, buried surface area (BSA) on gp1201 and gp1202 as well as total BSA for VRC01-class bnAbs (bottom).

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 3d

While in the lab Charlie worked on Ecm2

pubmed.ncbi.nlm.nih.gov/33547186/

Saccharomyces cerevisiae Ecm2 modulates the catalytic steps of pre-mRNA splicing - PubMed

Genetic, biochemical, and structural studies have elucidated the molecular basis for spliceosome catalysis. Splicing is RNA catalyzed and the essential snRNA and protein factors are well-conserved. Ho...

pubmed.ncbi.nlm.nih.gov

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 3d

Great to catch up with my former undergrad Charlie Schneider and @uwbiochem.bsky.social biochemistry major who is in town today and tomorrow representing Merck for the @uwmadisoncals.bsky.social Biotechnology Student-Employer Connector event!

today.wisc.edu/events/view/...

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Reposted by Aaron and the Hoskins Lab at UW Madison

WARF (Wisconsin Alumni Research Foundation) @warfnews.bsky.social · 4d

The long-term goal of @cijilim.bsky.social's research group is to understand how mammalian telomeres safeguard the genome. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_lim/

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 6d

new from Olga's lab @olgaanczukow.bsky.social

www.biorxiv.org/content/10.1...

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing Events

Alternative splicing generates different mRNA isoforms from single genes, generating protein diversity essential for normal development and tissue function. Dysregulation of splicing is implicated in ...

www.biorxiv.org

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Reposted by Aaron and the Hoskins Lab at UW Madison

Abhishek Chatterjee @achemsynbio.bsky.social · 7d

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics

Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...

rdcu.be

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 7d

Important new work out from Soo-chen (Happy Retirement!) on the role(s) of Sub2 and Prp5 during spliceosome assembly.

pubmed.ncbi.nlm.nih.gov/41027713/

New mechanistic insights into Prespliceosome formation-Roles of DEAD-box proteins Prp5 and Sub2 - PubMed

The spliceosome is a highly dynamic structure that undergoes continuous structural alterations through the sequential association and dissociation of small nuclear RNAs and protein factors during prec...

pubmed.ncbi.nlm.nih.gov

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Reposted by Aaron and the Hoskins Lab at UW Madison

ThePatrick&WatsonLabs @thepwlab.bsky.social · 7d

If you are somehow still compelled to be a PI in the world in which we find ourselves, we'd love to have you as a colleague!

Two positions in Biochemistry at Vanderbilt University.

www.nature.com/naturecareer...

www.nature.com/naturecareer...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515

Department of Biochemistry, School of Medicine—Basic Sciences

www.nature.com

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 7d

From Elif

www.cell.com/trends/cell-...

Is mitochondrial function at the heart of ribosome-related diseases?

Defects in ribosomal machinery cause ribosomopathies such as Diamond Blackfan anemia, classically linked to impaired protein synthesis. However, emerging evidence places mitochondrial dysfunction as a...

www.cell.com

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 7d

Congratulations Bart!

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 8d

This will be an undergrad assignment soon...

www.nature.com/articles/s41...

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase in conditions of low NAD+.

www.nature.com

Reposted by Aaron and the Hoskins Lab at UW Madison

Junior RNA scientists @jrrnascientists.bsky.social · 8d

🚨🚀 Save the date! Applications for two @RNASociety Junior Representative positions open October 16. Stay tuned for how to apply! #RNASociety #RNA

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Reposted by Aaron and the Hoskins Lab at UW Madison

Laura White @laurakwhite.bsky.social · 8d

The grad student organizers of Colorado's long-running RNA Club have been putting together this event to demystify the PhD application process for the past few years. Pass along to folks applying to grad school this cycle 🍁

It's a flyer for Colorado RNA Club's Undergrad Day event on Oct 21st at 1:30PM.

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 8d

We tried this a long time ago and only were able to get as far as a SNAP tag binding aptamer. Happy to see it work!

pubmed.ncbi.nlm.nih.gov/26538152/

Evolution and characterization of a benzylguanine-binding RNA aptamer - PubMed

Repurposing the "protein-labeling toolkit" for RNA research could be a pragmatic approach for developing new RNA-labeling methods. We have evolved an RNA aptamer that tightly binds benzylguanine (bG),...

pubmed.ncbi.nlm.nih.gov

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 8d

I love this idea from @chlab.bsky.social so much...

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates - Walunj - 2025 - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates

SNAPR is a ribozyme that repurposes O6-benzylguanine SNAP-tag substrates for site-specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. Th...

onlinelibrary.wiley.com

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 8d

I read that as mRNP and was like Karolin is working on RNA now?!?!??

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 9d

pubmed.ncbi.nlm.nih.gov/41016390/

DROL1/DIB1 determines U5 snRNP specificity for intron terminal dinucleotide in Arabidopsis - PubMed

Most introns contain GT-AG terminal dinucleotides; although some eukaryotes have introns with AT-AC termini whose splicing is impaired in the Arabidopsis defective repression of OLE3::LUC 1 (drol1) mu...

pubmed.ncbi.nlm.nih.gov

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 9d

uofuhealth.utah.edu/newsroom/new...

From Bench to Breakthrough: How Curiosity Led to an Extraordinarily Effective HIV Drug

Federally funded basic research at the University of Utah laid the groundwork for a new HIV-prevention drug now approved for clinical use—demonstrating how curiosity-driven science delivers real-world...

uofuhealth.utah.edu

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 9d

Very happy that Wes Sundquist agreed to deliver the keynote address at ASBMB 2026! For those of you who don't know, his work as key to the development of the new anti-HIV medication Lenacapavir!

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 9d

#ASBMB26's keynote speaker is Wesley Sundquist: Co-chair of the department of biochemistry at @uofubiochem.bsky.social, ASBMB fellow and one of Time's 100 most influential people of 2025. Don't miss his speech at ASBMB 2026!
ow.ly/SxoY50X454R
#HIV #StructuralBiology #ProteinDesign

Text reads Keynote Speaker Wesley Sundquist, Professor and department of biochemistry co-chair, University of Utah. There is a photo of Sundquist and the background is a scientific image behind a blue, pink and orange gradient.

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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 10d

Very excited about next week's RNA Maxigroup seminar from Kristen Lynch @upenn.edu ! Thanks to @rnasociety.bsky.social , @uwbiochem.bsky.social, and the CMB program for sponsoring!

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