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Reposted by Mike Cohen

Jeremy Berg @jeremymberg.bsky.social · Jul 17

My quote of the day

A Video Quote

Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.

(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

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Reposted by Mike Cohen

Thiago Carvalho @cyrilpedia.bsky.social · Jul 13

'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows

www.nytimes.com

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Reposted by Mike Cohen

ahellab.bsky.social @ahellab.bsky.social · Jul 10

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

www.nature.com

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Reposted by Mike Cohen

Andrii Gorelik @andriigorelik.bsky.social · Jul 10

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

www.nature.com

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Mike Cohen @michaelnadbio.bsky.social · Jul 10

Congrats Jeremy! Well-deserved!

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Mike Cohen @michaelnadbio.bsky.social · Jul 9

Exciting times in the fields of ADP-ribosylation and ubiquitylation!

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Mike Cohen @michaelnadbio.bsky.social · Jul 9

This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41...

And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...

reveal RNF114 as a reader and writer of MARUbylation.

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Mike Cohen @michaelnadbio.bsky.social · Jul 9

Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.

The Matić Lab @maticlab.bsky.social · Jul 9

Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...

www.nature.com

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Mike Cohen @michaelnadbio.bsky.social · Jul 7

Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.

Kevin Wright @kevinmawright.bsky.social · Jul 7

news.ohsu.edu/2025/07/02/o...

OHSU researchers discover link between key protein and brain synapse development

The protein is linked to a type of muscular dystrophy.

news.ohsu.edu

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Mike Cohen @michaelnadbio.bsky.social · Jul 3

Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!

Rose Z. Hill, Ph.D. @rose-hill.bsky.social · Jul 3

Our review on kidney sensory innervation is out! It was such an honor to write about all the amazing work from my colleagues in this growing field of renal interoception. Yay kidneys! www.sciencedirect.com/science/arti...

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Mike Cohen @michaelnadbio.bsky.social · Jun 25

Very cool finding, Matt. Congrats!

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Mike Cohen @michaelnadbio.bsky.social · Jun 22

💯 👇!

Neel Shah @nshahlab.bsky.social · Jun 21

Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!

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Mike Cohen @michaelnadbio.bsky.social · Jun 20

Great seeing both of you!

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Reposted by Mike Cohen

Pete Buttigieg @petebuttigieg.bsky.social · Jun 12

Today they have crossed a deep red line.

We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.

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Mike Cohen @michaelnadbio.bsky.social · Jun 12

Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.

ahellab.bsky.social @ahellab.bsky.social · Jun 12

Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS

PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell g...

www.pnas.org

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Reposted by Mike Cohen

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jun 9

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

Jeremy Berg @jeremymberg.bsky.social · Jun 9

www.standupforscience.net/bethesda-dec...

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Mike Cohen @michaelnadbio.bsky.social · Jun 8

😂. Hopefully Proctor’s gym has been upgraded to include a post-game recovery room, with cold baths and compression gear-haha. Every time I go out and play my body’s reminding me I’m not 25 anymore!

Mike Cohen @michaelnadbio.bsky.social · Jun 8

@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!

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Reposted by Mike Cohen

Jonathan Pruneda @jnpruneda.bsky.social · Jun 8

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

Jonathan Pruneda @jnpruneda.bsky.social · May 17

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

www.biorxiv.org

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Mike Cohen @michaelnadbio.bsky.social · Jun 8

Yeah, this was definitely a major milestone for her. Amazing come from behind victory!

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Mike Cohen @michaelnadbio.bsky.social · Jun 4

Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!

tafesselab.bsky.social @tafesselab.bsky.social · Jun 4

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

www.biorxiv.org

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Reposted by Mike Cohen

ahellab.bsky.social @ahellab.bsky.social · May 24

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...

'

my.corehr.com

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Mike Cohen @michaelnadbio.bsky.social · Jun 3

Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.

Nature Chemical Biology @natchembio.nature.com · Jun 3

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening

www.nature.com/articles/s41...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology

This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

www.nature.com

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Reposted by Mike Cohen

Jordan Meier @doc-jlmeier.bsky.social · Jun 3

Tagging a few bioorganic aficionados @laurakiessling.bsky.social @carolynbertozzi.bskyverified.social @krishnanyamuna.bsky.social @chembiobryan.bsky.social @chembiohub.bsky.social @pottslab.bsky.social @dannomura.bsky.social @danharki.bsky.social @craigmcrews.bsky.social @ritastrack.bsky.social

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Mike Cohen @michaelnadbio.bsky.social · May 29

🤣