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Reposted

Heran Darwin, PhD @heran.bsky.social · 1d

We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783

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Reposted

James Saenz @jamessaenz.bsky.social · 14d

🌶️ Lipids bring the heat 🔥

Lipids don’t just shape membranes, they influence cellular metabolism.

We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠

Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉

www.biorxiv.org/content/10.1...

Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism

The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...

www.biorxiv.org

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Reposted

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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tafesselab.bsky.social @tafesselab.bsky.social · Aug 21

Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!

Jeremy Baskin @jeremybaskin.bsky.social · Aug 20

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

www.nature.com

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tafesselab.bsky.social @tafesselab.bsky.social · Aug 12

Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.

Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.

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tafesselab.bsky.social @tafesselab.bsky.social · Aug 5

Congratulations, Itay!

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Reposted

King Lab @kinglabipd.bsky.social · Aug 1

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

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Reposted

Levental Lab @leventallab.bsky.social · Jul 18

Great news!!

Does anyone know what bill will determine NIH funding levels?

Nigel Goldenfeld @nigelgoldenfeld.bsky.social · Jul 18

🧪 Good news, for now at least.

Senate Appropriations Committee passes the Commerce, Justice and Science Bill.

NSF: flat funding, not -55% as requested by Trump!

NIST, NOAA, NASA get strong support, R's push back cuts requested by Trump.

Summary:

www.appropriations.senate.gov/imo/media/do...

www.appropriations.senate.gov

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tafesselab.bsky.social @tafesselab.bsky.social · Jul 2

Promoted to Full Professor with tenure!

This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.

Excited for what’s next- here to the future! 🙌

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tafesselab.bsky.social @tafesselab.bsky.social · Jun 26

Congratulations, Jeremy!

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tafesselab.bsky.social @tafesselab.bsky.social · Jun 18

Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

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tafesselab.bsky.social @tafesselab.bsky.social · Jun 10

It’s finally out!

Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊

Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social

pubmed.ncbi.nlm.nih.gov/40473211/

Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed

Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...

pubmed.ncbi.nlm.nih.gov

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tafesselab.bsky.social @tafesselab.bsky.social · Jun 4

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

www.biorxiv.org

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Reposted

OHSU-MMI @ohsummi.bsky.social · May 23

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Kristin Michel @kmichel.bsky.social · May 22

Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...

In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature

An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...

www.nature.com

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tafesselab.bsky.social @tafesselab.bsky.social · May 19

Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!

@ohsunews.bsky.social @ohsummi.bsky.social

www.nature.com/articles/s43...

Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine

Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...

www.nature.com

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Reposted

OHSU-MMI @ohsummi.bsky.social · Apr 30

Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...

Analysis of Factors That Regulate HIV-1 Fusion in Reverse

Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...

pmc.ncbi.nlm.nih.gov

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tafesselab.bsky.social @tafesselab.bsky.social · Apr 1

Excellent work!

John Burke @jburkevic.bsky.social · Mar 31

New work out from my lab by my graduate student Isobel in collaboration with Josh Pemberton and Tamas Balla. Provides some new cool tools to manipulate PI3,5P2 levels, as well as some new insight into PIKfyve regulation.
rupress.org/jcb/article-...

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate

In this paper, Pemberton et al. describe the generation and characterization of an engineered active fragment of the PIKfyve enzyme and its use to generate

rupress.org

tafesselab.bsky.social @tafesselab.bsky.social · Mar 15

Congrats, Bella and the the team!

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tafesselab.bsky.social @tafesselab.bsky.social · Mar 6

Thank you, John!

tafesselab.bsky.social @tafesselab.bsky.social · Mar 4

I had an amazing time visiting University of Victoria @uvic.ca It was wonderful meeting students and faculty- thank you so much, John Burke @jburkevic.bsky.social, for hosting me!
#lipids and #nanobodies

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Reposted

Sphingolipid Biology @slbiology.bsky.social · Feb 4

The early bird deadline may have passed but there is still plenty of time to register and submit abstracts for the 2025 FEBS/ICC! Come to historic Varna for sun, sea, and sphingolipid science!!

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Reposted

Sphingolipid Biology @slbiology.bsky.social · Feb 20

The Obeid award was created to honor the legacy of the late, great Lina Obeid, a giant of the Sphingolipid field and a strong proponent of women in science. We are privileged to present this award at FEBS/ICC 2025 and are very grateful to CaymanChemical for their sponsorship.

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Reposted

Sphingolipid Biology @slbiology.bsky.social · Feb 21

The Kester award honors the legacy of Mark Kester, a sphingolipid researcher with an entreprenurial drive, and a leader in sphingolipid therapies, particularly ceramide nanoliposomes. We will present the award at FEBS/ICC 13 2025 and thank CaymanChemical for their sponsorship.

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tafesselab.bsky.social @tafesselab.bsky.social · Feb 19

This is terrible for science, and will have huge consequences!

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