James Saenz
@jamessaenz.bsky.social
1.6K followers 2.2K following 160 posts
Geochemist and biologist, Interested in lipids, RNA, pathogens, & synthesis of life.
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jamessaenz.bsky.social
How do lipids shape life? I explore this question in my recent talk for the Build-a-Cell 🦠 seminar series. Thanks to @kateadamala.bsky.social for hosting! Watch it here: youtu.be/JnF7hPCiSbI?...
Build-a-Cell seminar James Saenz: Harnessing minimal cells to understand the living membranes
YouTube video by Build-a-Cell
youtu.be
Reposted by James Saenz
raflynn5.bsky.social
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
Reposted by James Saenz
dimovalab.bsky.social
🎉 Congratulations to the winners of the Best Poster Awards at #BiomembraneDays2025 sponsored by @lipotype.bsky.social

🏆Manpreet Kaur (with @fabiololicato.com &W. Nickel)
🏆Jana Kroll (@janakroll.bsky.social @mdc-berlin.bsky.social)
🏆Ha Ngoc Anh Nguyen (with @jamessaenz.bsky.social)

🚀Science rocks!
Reposted by James Saenz
uliaafonina.bsky.social
Loved listening to all the fantastic talks at #BiomembraneDays2025 — such a cool atmosphere to learn and get inspired! Also nervous but excited to present my poster and share my work. Huge thanks to the Saenz group and my amazing supervisor James for making it possible ✨ 💅🏻
Reposted by James Saenz
anh-nhn.bsky.social
I’m truly honored to have received the Poster Award at #BiomembraneDays! Huge thanks to the organizers for an excellent conference and to the Saenz Lab for their continuous support!
jamessaenz.bsky.social
Congratulations to @anh-nhn.bsky.social for winning the @lipotype.bsky.social poster award at #BiomembraneDays Berlin! 🎉🔥 @bcube-tud.bsky.social
jamessaenz.bsky.social
Celebrating the last night of Biomembrane Days with a proper German meal 🍺
jamessaenz.bsky.social
Congratulations to @anh-nhn.bsky.social for winning the @lipotype.bsky.social poster award at #BiomembraneDays Berlin! 🎉🔥 @bcube-tud.bsky.social
jamessaenz.bsky.social
Super cool talk!!
dimovalab.bsky.social
Seraphine Wegner showed how to make membranes talk - light-based communication at the #BiomembraneDays25

@sigsyncell.bsky.social @comeincell.bsky.social
Reposted by James Saenz
josiegz.bsky.social
"We see a handful of large platforms harvesting users’ private data to share with commercial brokers or even repressive governments. We see ubiquitous algorithms that are addictive by design and damaging to our teenagers’ mental health."

--Tim Berners-Lee

www.theguardian.com/technology/2...
Why I gave the world wide web away for free | Tim Berners-Lee
My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for
www.theguardian.com
Reposted by James Saenz
nagissa.bsky.social
Deep ocean microbes are starving but does feeding them fresh carbon make them eat the old stuff?

Our new study shows it doesn’t. The persistence of this carbon appears to come from its chemical stability, not from microbial starvation.

🌊🦠 🧪 #MicroSky #MarineSky

journals.asm.org/doi/epub/10....
Testing the priming effect in the deep ocean: are microorganisms too starved to consume recalcitrant organic carbon?
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journals.asm.org
Reposted by James Saenz
markusdeserno.bsky.social
Major cool membrane conference coming up next week! The Biomembrane Days 2025, organized by an amazing team from the MPI for Colloids and Interface Science @mpici.bsky.social: Rumy Dimova (@dimovalab.bsky.social), Helge Ewers, and Thomas Weikl. I'm so very much looking forward to attending! 🤩 🧪
Biomembrane Days 2025
Membranes form the intricately shaped compartments of life. The Biomembrane Days are a triannual workshop that highlights recent advances in understanding the morphology and molecular organization of ...
events.mpikg.mpg.de
jamessaenz.bsky.social
🌶️ Lipids bring the heat 🔥

Lipids don’t just shape membranes, they influence cellular metabolism.

We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠

Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉

www.biorxiv.org/content/10.1...
Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
www.biorxiv.org
jamessaenz.bsky.social
🎉 Congratulations to Varvara Kramkova on a successful Master’s thesis defense, exploring the minimal set of lipids required to sustain life 🦠 @bcube-tud.bsky.social
jamessaenz.bsky.social
Beautiful sky at sunset in Dresden this evening
jamessaenz.bsky.social
🎉Congratulations to Tess Rudd @tessrudd.bsky.social on successfully defending her Master’s thesis, exploring the evolution of membrane phenotypes in the Minimal Cell 🦠 JCVI-Syn3 @bcube-tud.bsky.social
Reposted by James Saenz
jamessaenz.bsky.social
So much mist over the Elbe this morning
jamessaenz.bsky.social
Breakfast at sunrise on the @ceskedrahyofficial.bsky.social 🚂 from Prague to Dresden