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Karla Feijs-Žaja @kfeijszaja.bsky.social · 21d

Seeing how I always comment on train connections when traveling in Germany... My train is on time 🎉 Which means I'll be arriving an hour and a half early 😅 See you later at the @gbmev.bsky.social GBM Compact Meeting in Frankfurt!

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Sep 4

I remember the reviewer who once said our manuscript is "a cornucopia of mistakes". That was really helpful indeed 😐

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 22

I'm grateful for Nonso's hard work on this project, Jörg's assistance with autophagy, Bernhards' hosting of our little group and the excellent teamwork with Roko.

The reviewers and editor from the Journal have also been great to shape the revisions and make the paper better.

Thank you all 🙏

Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 22

Do other PARPs label substrates for degradation as well? In which conditions is this most relevant? How do ADP-ribose and ubiquitin connect to regulate degradation?

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 22

This is a very exciting finding, as it connect well with several recent publications that indicate that proteins modified by PARP7 are degraded. For example: doi.org/10.1016/j.ce...
doi.org/0.1038/s4431...
doi.org/10.1101/2025...

It also leaves many questions to be answered in future:

Redirecting

doi.org

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 22

I'm very excited to be able to share the latest work from our group with you:

doi.org/10.1038/s443...

We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.

PARP7 is a proteotoxic stress sensor that labels proteins for degradation | The EMBO Journal

imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins for efficient degradation during proteotoxic ...

doi.org

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 17

The advantage of having a Croatian husband, is that you can find beautiful spots to spend some time away from everything 😏

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Aug 15

Perhaps Midnight Library by Matt Haig?

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Reposted by Karla Feijs-Žaja

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Aug 4

Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S"
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!

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Reposted by Karla Feijs-Žaja

Biochemical Society @biochemsoc.bsky.social · Aug 4

Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8

The Biochemical Society 2027 Awards. Our 2027 Awards are now open for nominations! Deadline 3 November 2025

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Reposted by Karla Feijs-Žaja

Jonny Edwards @veritasgaston.bsky.social · Jul 22

An incomparable legend.

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Reposted by Karla Feijs-Žaja

Trends in Genetics @cp-trendsgenetics.bsky.social · Jul 8

"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues

"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."

Read it here:
authors.elsevier.com/sd/article/S...

Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Jul 5

Almost 80 but what an energy - Neil Young! I am so grateful to have seen him play with the Chrome Hearts yesterday 🤩 Rock 'n' roll will never die...

Neil young and the Chrome hearts on stage. Background text love earth

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Reposted by Karla Feijs-Žaja

The Company of Biologists @biologists.bsky.social · Jun 19

Enter our essay competition and win £250. Share with us your ideas on how to innovate event organisation to have a lower environmental impact.

Entry deadline: Friday 20 June

Enter now: www.biologists.com/stories/essa...

#Innovation #Sustainability #Environment

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Reposted by Karla Feijs-Žaja

Stephen Graham's Lab @atomicvirology.bsky.social · Jun 19

Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏

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Reposted by Karla Feijs-Žaja

The EMBO Journal @embojournal.org · Jun 12

Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes
www.embopress.org/doi/full/10....

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Reposted by Karla Feijs-Žaja

sigtrans.bsky.social @sigtrans.bsky.social · May 26

Registration is OPEN for the 28th Signal Transduction Society Meeting—first-ever #CellCommSummit!
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit

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Reposted by Karla Feijs-Žaja

Ted Pavlic (he/him/his) @tedpavlic.bsky.social · Jun 8

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific

A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

www.richmondscientific.com

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Reposted by Karla Feijs-Žaja

Journal of Cell Biology @jcb.org · Jun 5

We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 careers.rockefeller.edu/jobs?keyword...

#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs

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Karla Feijs-Žaja @kfeijszaja.bsky.social · Jun 5

The newest addition to my board game collection just arrived 🤩 Need a game night soon then 😁 #publishorperish

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Reposted by Karla Feijs-Žaja

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Jun 4

🏆 𝐑𝐨𝐥𝐚𝐧𝐝 𝐒𝐜𝐡𝐚𝐮𝐞𝐫 𝐍𝐚𝐜𝐡𝐰𝐮𝐜𝐡𝐬𝐩𝐫𝐞𝐢𝐬: Deadline bis 30.06.2025 verlängert! 2.000 € für exzellente Forschung in #Glykobiologie. Bewerben können sich junge Wissenschaftler:innen. Infos & Bewerbung: [email protected] und gbm-online.de/en/news-even... #Nachwuchsförderung #GBM

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Karla Feijs-Žaja @kfeijszaja.bsky.social · May 28

Interested in doing a postdoc in Germany, on a topic involving ADP-ribosylation of proteins or RNA? Or even the novel dual modification with ubiquitin attached to proteins via ADP-ribose?? If yes ➡️ do get in touch 😊

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Reposted by Karla Feijs-Žaja

Silvia Ramundo @sramundo.bsky.social · May 19

Calling all last-minute legends!
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉

Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · May 5

If you’re a scientist who values strong institutional support, join us! The GMI is currently hiring new Group Leader positions, including a Junior Group Leader to lead an independent research group addressing fundamental questions in molecular plant biology. Links below.

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Reposted by Karla Feijs-Žaja

Mike Cohen @michaelnadbio.bsky.social · May 17

Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!

Jonathan Pruneda @jnpruneda.bsky.social · May 17

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

www.biorxiv.org

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Karla Feijs-Žaja @kfeijszaja.bsky.social · May 17

I recently rediscovered Terry Pratchett. The little nuggets of wisdom sprinkled throughout his works are amazing. I do appreciate them much more these days then when first reading Pratchett 20 years ago...

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