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Rune Busk Damgaard @rbdamgaard.bsky.social · 2d

🚀 Off to our Research Retreat with the Section for Medical Biotechnology, DTU Biotechnology and Biomedicine.

Two days of science, ideas & innovation 🧬💡
12 faculty pitches, 30+ PhDs & postdocs, and endless opportunities for new collaborations 🔬🤝✨

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Reposted by Rune Busk Damgaard

Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

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Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

Hope this serves as a useful overview for anyone working on ubiquitin signalling or PTMs. Big thanks to those who did the heavy lifting in the writing process: Julian Koch, Camilla Reiter Elbæk & @dompri.bsky.social 🙌😊

Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

We also highlight:
✅ Trade-offs between specificity, throughput, & sensitivity
✅ Gaps in the current toolbox where innovation is needed
✅ The value of combining orthogonal methods for robust insight

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Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

…alongside analytical platforms such as:
✅ Immunoblotting 🧫📊
✅ Fluorescence microscopy 🔬🌈
✅ Enzymatic assays 🧪⏱️
✅ Mass spectrometry ⚡📈

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Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

In the review, we summarise state-of-the-art tools for probing linkage-type specificity:
🎯 Antibodies & antibody-like molecules
🎯 Affimers
🎯 Engineered Ub-binding domains
🎯 Catalytically inactive deubiquitinases
🎯 Macrocyclic peptides

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Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

Why this matters ⬇️
Ubiquitin chain diversity, i.e. different linkage types, mixed or branched chains, is central to cell signalling.
But analysing these chain types specifically remains a big challenge.

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Rune Busk Damgaard @rbdamgaard.bsky.social · 23d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

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Rune Busk Damgaard @rbdamgaard.bsky.social · Aug 14

Is it still useful to insist that authors spell out every protein name in research papers? Many names are long, obscure, and say nothing about function... we might as well call them James, Joan, and John.

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Reposted by Rune Busk Damgaard

TanentzapfLab @tanentzapflab.bsky.social · Aug 13

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

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victor @heldigt.bsky.social · Jul 3

Jeg er godt træt af måden regeringens spareplan rammer universiteterne.

Regeringens sult efter at afskaffe bureaukratiet er gået for vidt, når den nu rammer forskerne

Regeringen hævder, at der med de nye besparelser på universiteterne ikke vil gå midler fra forskning. Men forskere arbejder ikke i et vakuum. Når administrationen fjernes, ryger tiden fra forskningen

klik1.information.dk

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Reposted by Rune Busk Damgaard

Richard Sever @richardsever.bsky.social · Jul 2

the really key number to remember is that biorxiv serves the entire global science community, posting thousands of papers per month for millions of readers, and it's entire running costs ( a few $M/year) are less than some single labs....

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Prasad Jallepalli, MD, PhD @prasad.bsky.social · May 23

it’s a global contest, whether we want to compete or watch from the sidelines

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Sakamoto Lab @labsakamoto.bsky.social · May 16

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

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David Vilchez @thevilchezlab.bsky.social · May 15

We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

Postdoc Position (f/m/x)

We are looking to support our rapidly growing team as soon as possible:

jobs-uk-koeln.onlyfy.jobs

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Reposted by Rune Busk Damgaard

Fletcher Lab @fletcherlab.bsky.social · May 13

Great to see this out. A story that spanned continents, cities and budget codes…

www.nature.com/articles/s41...

Big thanks to all the teams involved!

@clausenlab.bsky.social @e3chembio.bsky.social

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications

RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...

www.nature.com

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Rune Busk Damgaard @rbdamgaard.bsky.social · May 13

Congrats!!

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Rune Busk Damgaard @rbdamgaard.bsky.social · May 13

Haven’t shared this in a while. But the #ubiquitin and #ubl Starter Pack now includes 116 profiles to follow if you’re interested in the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

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Reposted by Rune Busk Damgaard

Rune Busk Damgaard @rbdamgaard.bsky.social · Apr 22

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

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Rune Busk Damgaard @rbdamgaard.bsky.social · Apr 22

Our review is published alongside a long list of other excellent reviews in a special issue of ChemBioChem (chemistry-europe.onlinelibrary.wiley.com/doi/toc/10.1... edited by @jnpruneda.bsky.social and Monique Mulder. Thanks a lot for the invitation to contribute to this fantastic issue.

Decoding the Ubiquitin System Using Chemical Biology Tools: ChemBioChem

ChemBioChem is an international journal connecting chemistry and biology, covering chemical biology, biochemistry, synthetic biology, biomaterials & more.

chemistry-europe.onlinelibrary.wiley.com

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Rune Busk Damgaard @rbdamgaard.bsky.social · Apr 22

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

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Rune Busk Damgaard @rbdamgaard.bsky.social · Mar 18

Congratulations, Elton and team!

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

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Randall Munroe @xkcd.com · Mar 17

Lungfish xkcd.com/3064

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Kristian Pedersen @pdrsn.bsky.social · Mar 5

Nysgerrighedsdrevet, uafhængig forskning er en samfundssøjle - i disse tider er det mere tydeligt end nogensinde. Og EU har en særlig vigtig rolle.

Jesper Langergaard @jesperlangergaard.bsky.social · Mar 5

European Research Council må ikke blive udvandet ifm forhandlingerne om EU’s forskningsbudget. ERC skal forblive en uafhængig enhed, der investerer i nysgerrighedsdreven forskning - for det er grundlaget for de nye indsigter, der driver vores samfund fremad. www.information.dk/debat/2025/0...

Danske politikere må forsvare EU’s succesprogram for grundforskning

EU’s program, der siden 2007 har støttet de bedste forskningsprojekter i Europa, er potentielt i fare. Hvis pengene i stedet går til projekter ud fra vurderet markedspotentiale, vil det koste på EU’s ...

www.information.dk

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