This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin-mediated mitophagy through succination of specific cysteine residues in Parkin. This metabolite-induced modification disrupts Pa...

EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Nature Structural & Molecular Biology, Published online: 29 May 2025; doi:10.1038/s41594-025-01557-xAutophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

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Cell Death & Disease - NDP52 and its emerging role in pathogenesis

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Our cells are smart – they’re able to get rid of damaged parts and recycle useful parts to keep us healthy. This process seems to break down in conditions like Parkinson’s and Alzheimer’s disease, an...