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shaliniagarwal.bsky.social
Shalini Agarwal
@shaliniagarwal.bsky.social
110 followers 160 following 3 posts
Researcher @MRC PPU studying mitochondrial quality control. Interested in Mitophagy and ISR in ALS/MND #mitochondria #ISR #Pink1 #kinase #ALS
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shaliniagarwal.bsky.social
Shalini Agarwal @shaliniagarwal.bsky.social · Jun 5
Happy to have received a poster prize at the UK #Autophagy and #Proteostasis Conference!
Grateful to receive it from one of the leading figures in the field of proteostasis (@annebertolotti.bsky.social). A special thank you to the organisers for such a vibrant and insightful meeting!!
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Reposted by Shalini Agarwal
thanhrnguyen.bsky.social
Thanh Nguyen @thanhrnguyen.bsky.social · May 31
Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.
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Reposted by Shalini Agarwal
pdc-lab.bsky.social
De Camilli Lab @pdc-lab.bsky.social · Apr 10
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
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Reposted by Shalini Agarwal
cvasilescu.bsky.social
Catalina Vasilescu, PhD @cvasilescu.bsky.social · May 11
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
pmc.ncbi.nlm.nih.gov/articles/PMC...
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
Loss-of-function mutations in the PINK1 kinase lead to early-onset Parkinson’s disease (PD). PINK1 is activated by mitochondrial damage to phosphorylate ubiquitin and Parkin, triggering mitophagy. PIN...
pmc.ncbi.nlm.nih.gov
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shaliniagarwal.bsky.social
Shalini Agarwal @shaliniagarwal.bsky.social · May 13
x.com/mrcppu/statu...
MRC PPU on X: "MRCPPU researchers discover new drug target for #Parkinson’s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct" / X
MRCPPU researchers discover new drug target for #Parkinson’s disease https://t.co/b2bvyvahXN https://t.co/6NMtKWpXct
x.com
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shaliniagarwal.bsky.social
Shalini Agarwal @shaliniagarwal.bsky.social · May 12
Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration
@mrcppu.bsky.social

www.science.org/doi/10.1126/...
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.
www.science.org
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