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Reposted by Assoc. Professor Tim J Sargeant

The Journal of Physiology @jphysiol.bsky.social · 28d

Gabriela Geraldo Benzoni offers this #JournalClub article discussing time-restricted feeding and autophagic flux based on the recent work of Bensalem et al. (2025) ✍️

🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Reposted by Assoc. Professor Tim J Sargeant

JCI insight @insight.jci.org · Sep 7

ICYMI: Autophagy is linked to health span and modified by nutrition.

@timsargeant.bsky.social show a high-protein meal does not alter autophagic flux in human peripheral blood mononuclear cells within 1 hour—challenging the notion that fasting activates autophagy.

buff.ly/aPrgr5F

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Aug 25

Check out our new paper! We tested whether a high protein milkshake would suppress #autophagy measured in human blood after 1 hour. Surprisingly we got a negative result, despite clear metabolic responses. @sahmri.bsky.social @jci-insight.bsky.social

insight.jci.org/articles/vie...

JCI Insight - High protein does not change autophagy in human PBMCs after 1 hour

insight.jci.org

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Aug 20

I am so bad at this!

Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Aug 18

Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people:

www.tandfonline.com/doi/full/10.... @sahmri.bsky.social

Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction

Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a ...

www.tandfonline.com

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Aug 13

Well worth a five minute read - Interventional study showing lifestyle interventions boost #cognition during #aging - the structured intervention group focused on #exercise, #diet advice, and cognitive exercises. Lifestyle is important for #brain aging! www.alzforum.org/news/confere...

Lifestyle Makeover Boosts Cognition in Older Adults | ALZFORUM

www.alzforum.org

Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Jun 12

New research paper on human #autophagy from our group at @sahmri.bsky.social. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/... #aging

faseb.onlinelibrary.wiley.com

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Jun 5

Check out our new paper from @sahmri.bsky.social in @plosone.org - measurement of #autophagy using the tf-LC3 system in ageing mice with high fat diet-induced obesity. Tissue-specific responses show us the relationship between autophagy and #ageing is complicated. dx.plos.org/10.1371/jour...

Autophagy across tissues of aging mice

Autophagy is a ‘waste-disposal’ pathway that protects against age-related pathology. It is widely accepted that autophagy declines with age, yet the role that sex and diet-related obesity play during ...

dx.plos.org

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Jun 4

Sunrise from @sahmri.bsky.social with the Adelaide Oval and St Peter's Cathedral

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · Jun 4

A/Prof @timsargeant.bsky.social is the latest guest to feature on the Community Conversations podcast. 🎙️

A/Prof Sargeant discusses all things autophagy - the latest research, lifestyle interventions, tips for optimising cellular health and more!

Listen 🎧 sahmri.au/CC-Tim-Sarge...

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Reposted by Assoc. Professor Tim J Sargeant

Lorenz Adlung Lab @adlunglab.com · May 22

🍽️ Can autophagy increase with age rather than decline?
🤔 What if the story we’ve been told about its decline is missing key details? ⤵️ #aging

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Reposted by Assoc. Professor Tim J Sargeant

Thanh Nguyen @thanhrnguyen.bsky.social · May 31

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · May 30

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

11th International Symposium on Autophagy

www.isa11.org

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · May 9

Over his career, Emeritus Professor John Hopwood AM set the bar for innovative research.

Now, he and his wife Barbara provide philanthropic support, insisting their donations not be restricted to specific projects to create scientific freedom.

Read 📖 sahmri.au/Cost-of-Rese...

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Reposted by Assoc. Professor Tim J Sargeant

The Journal of Physiology @jphysiol.bsky.social · May 22

Julien Bensalem et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans 🍽️ 🔬

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · May 21

Crucial new pilot study to investigate whether #rapamycin can be used against dementia causing diseases published yesterday.

www.nature.com/articles/s43...

Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial - Communications Medicine

Gonzales et al. conducted an open-label phase 1 clinical trial of rapamycin for mild cognitive impairment and dementia due to Alzheimer’s disease. Rapamycin is not detected in cerebrospinal fluid befo...

www.nature.com

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · May 10

New study: we measured autophagic flux in human blood and compared intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Intermittent time‐restricted eating may increase autophagic flux in humans: an exploratory analysis

Abstract figure legend In this study we used a physiologically relevant measure of autophagic flux in human peripheral blood mononuclear cells (PBMCs) to determine the effect of calorie restriction a....

physoc.onlinelibrary.wiley.com

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Reposted by Assoc. Professor Tim J Sargeant

Oregon 🕎🎲 @oregonthedm.bsky.social · Apr 9

Biggest commitment to a 3 second joke I've ever seen

880 28K 89K

Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Apr 8

Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea.

www.nature.com/articles/s41...

Autophagy does not always decline with ageing - Nature Cell Biology

Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing tissue-specific variability and, ...

www.nature.com

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · Apr 3

New research shows giving antibiotics to newborns can reduce their immune response to vaccines, likely due to changes in gut bacteria. 🦠

This research, led by Prof @davidjlynn.bsky.social, was featured in @nature.com, one of the world's most prestigious journals.

📰 sahmri.au/Newborn-Anti...

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Mar 30

Great commentary on 'lysohormesis', for all you longevity fans out there:

"Just as physical exercise stresses the body to build stronger
muscles, a controlled mild stress to lysosomes could boost resilience and improve health outcomes across the lifespan."

www.nature.com/articles/s41...

Harnessing lysohormesis for healthy ageing - Nature Cell Biology

Lysosomal dysfunction is emerging as a common pathogenic mechanism underlying normal ageing and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by mild lysosomal stre...

www.nature.com

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Mar 22

Matt Kaeberlein giving his opinion on direct to consumer biological ageing tests and the ageing field in general. Definitely worth a watch.

youtu.be/8mlRkXZFvi8?...

The Truth About Biological Age Tests

YouTube video by Dr Matt Kaeberlein

youtu.be

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Mar 22

Good news on the dementia front - incidence is dropping - "Scientists don’t know what may have had the biggest impact, but recent studies have emphasized the effects of modifiable factors such as exercise, smoking, hearing loss, and hypertension on dementia risk"

www.alzforum.org/news/researc...

Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes. | ALZFORUM

www.alzforum.org

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Reposted by Assoc. Professor Tim J Sargeant

Korolchuk Lab @korolchuklab.bsky.social · Mar 16

#Autophagy and #mTOR papers from past two weeks, enjoy thanks to @biomednews.bsky.social search engine!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

a man with a skeleton in the background is wearing a science shirt

ALT: a man with a skeleton in the background is wearing a science shirt

media.tenor.com

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · Mar 14

Today, A/Prof @timsargeant.bsky.social accepted an incredibly generous donation following his gripping talk at the Sohn Hearts and Minds Conference last November. 👏

SAHMRI sends our most sincere thanks both to Sohn and the state government for the invaluable opportunity and support.

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