Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...

Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase

imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase a...

Nature Metabolism, Published online: 14 July 2025; doi:10.1038/s42255-025-01325-7Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Skeletal muscle is essential for movement and maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed of various cell types that hel...

People living with type 1 diabetes have significantly increased cardiovascular risk compared with the general population. Traditional risk factors include hypertension, dyslipidaemia, and obesity. How...

Nature Metabolism, Published online: 01 July 2025; doi:10.1038/s42255-025-01306-wSynapses have long been thought to rely exclusively on glucose metabolism for energy. In this issue of Nature Metabolism, Kumar et al. reveal that synapses can tap into fatty acid metabolism to fuel ATP production and maintain synaptic activity when glucose is limited.

The recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretag

Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise.

With PN-477, Protagonist is directly going up against Eli Lilly, which is advancing retatrutide, also a triple-G agonist, in a Phase II trial.

The invention in this patent application relates to pyrazolo-[1,5-<i>a</i>]-pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and ma...