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Sakamoto Lab @labsakamoto.bsky.social · 8d

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

www.biorxiv.org

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Juleen R. Zierath @juleenrzierath.bsky.social · 9d

Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social

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NNF Center for Basic Metabolic Research @cbmr.science · 10d

😅

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Tune H Pers @tunepers.bsky.social · 15d

Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026!

Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025

Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers

keysym.us/KSGutBrain26

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NNF Center for Basic Metabolic Research @cbmr.science · 10d

Read the Spotlight article in Nature Metabolism, here:

'Cold-season programming reinforces the brown fat–cardiometabolic health link'

www.sciencedirect.com/science/arti...

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Cold-season programming reinforces the brown fat–cardiometabolic health link

Recent work by Yoneshiro et al. links brown adipose tissue (BAT) activity to environmental temperatures during conception, highlighting intergeneratio…

www.sciencedirect.com

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NNF Center for Basic Metabolic Research @cbmr.science · 10d

Could the season you were conceived determine your lifelong health?

@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.

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European Association for the Study of Diabetes @easdnews.bsky.social · Sep 2

💡Meet Assoc. Prof. @adeshmukh.bsky.social ( @cbmr.science), #EFSD/ @novo-nordisk.bsky.social Future Leaders Awardee. His work uncovers exercise-induced peptides & #proteins that improve insulin sensitivity in #T2D.

📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).

📖 doi.org/10.1016/j.ce...

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Sakamoto Lab @labsakamoto.bsky.social · 29d

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

www.science.org

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Jens Lund @lundjens.bsky.social · 21d

Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻‍♂️‍➡️ 1/4

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The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Jens Lund @lundjens.bsky.social · Aug 8

@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3

The Journal of Physiology @jphysiol.bsky.social · Aug 7

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Federico Picciau @federicopicciau.bsky.social · Aug 8

A must read!

NNF Center for Basic Metabolic Research @cbmr.science · Aug 7

@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’

Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social

Read it here: www.cell.com/cell/fulltex...

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NNF Center for Basic Metabolic Research @cbmr.science · Aug 7

@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’

Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social

Read it here: www.cell.com/cell/fulltex...

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Nathalie Krauth @nkrauth.bsky.social · Aug 1

Looking for a Postdoc position? (great program with 3-year funding and running costs)

@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center

Being a program alumni I can can highly recommend the program and the Clemmensen lab :)

NNF Center for Basic Metabolic Research @cbmr.science · Aug 1

Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!

Four PhD and four Postdoc positions are currently available:

cbmr.ku.dk/join-us/fell...

#phdposition #postdocposition

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Sakamoto Lab @labsakamoto.bsky.social · Jul 9

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science

www.nature.com/articles/s41...

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Simon Wengert @simon-wengert.bsky.social · Jul 9

After an immensely enriching and rewarding PhD in @caina89.bsky.social lab at @pioneercampus.bsky.social, I am excited to announce that I moved to beautiful Copenhagen for my postdoc in Simon Rasmussen's group @cbmr.science!

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NNF Center for Basic Metabolic Research @cbmr.science · Aug 1

Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!

Four PhD and four Postdoc positions are currently available:

cbmr.ku.dk/join-us/fell...

#phdposition #postdocposition

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NNF Center for Basic Metabolic Research @cbmr.science · Jun 23

🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱

Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?

Prof. Jens Juul Holst outlines the evidence in Diabetes 👇

diabetesjournals.org/diabetes/art...

#GIP #GLP1 #biotech #obesity

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NNF Center for Basic Metabolic Research @cbmr.science · Jun 13

Scientists from @cbmr.science and the @ucph.bsky.social Department of Neuroscience have identified a neural circuit in the mouse’s brain that prioritises safety over other needs. The findings were published in @nature.com Neuroscience.

Read more, below 👇

healthsciences.ku.dk/newsfaculty-...

Safety becomes more important than foraging when a specific neuronal circuit in the brain is activated

Researchers from the University of Copenhagen have identified a neural circuit in the mouse’s brain which ensures that it prioritises safety over other needs, e.g. food seeking, and that this happens ...

healthsciences.ku.dk

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Juleen R. Zierath @juleenrzierath.bsky.social · Jun 7

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science

www.sciencedirect.com/science/arti...

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

www.sciencedirect.com

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Atul Deshmukh @adeshmukh.bsky.social · Jun 8

New publication!

We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.

www.sciencedirect.com/science/arti...

@cbmr.science @jeppekjaergaard.bsky.social

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

www.sciencedirect.com

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Atul Deshmukh @adeshmukh.bsky.social · Jun 3

Preprint Alert
We present the most comprehensive, time-resolved atlas of the human proteomic response to acute exercise. We mapped 10,000+ proteins across plasma, saliva & urine—3,000+ changed after just one workout.
doi.org/10.1101/2025...
Explore cbmr-rmpp.shinyapps.io/exerome/

Body Fluid Proteomic Landscape of Acute Exercise

Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva,...

doi.org

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Sakamoto Lab @labsakamoto.bsky.social · May 16

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

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Atul Deshmukh @adeshmukh.bsky.social · May 27

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

Redirecting

doi.org

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European Association for the Study of Diabetes @easdnews.bsky.social · May 30

🏆 Congrats Dr. Jens Lund (@cbmr.science &
& @ucph.bsky.social) for being awarded the EASD Rising Star Symposium & #EFSD Rising Star Fellowship for his research project: Circulating metabolites regulating energy homeostasis.

Looking forward to your #EASD2025 lecture & wish you continued success👏

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