Dipsikha Biswas
@itsmedipsikha.bsky.social
Researcher at CBMR, University of Copenhagen
Interested in science, politics, literature and food
Human rights advocate, anti war.
Interested in science, politics, literature and food
Human rights advocate, anti war.
Pinned
🎉👏 We’re thrilled to congratulate the 2025 #EFSD / Lilly Diabetes International Young Investigators Award recipients.
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
🎉👏 We’re thrilled to congratulate the 2025 #EFSD / Lilly Diabetes International Young Investigators Award recipients.
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
October 17, 2025 at 10:49 AM
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
Reposted by Dipsikha Biswas
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
September 30, 2025 at 10:42 AM
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dipsikha Biswas
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Dipsikha Biswas
Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾
& this year was @keisakamoto.bsky.social personal best 🙌🍾
September 2, 2025 at 10:50 AM
Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾
& this year was @keisakamoto.bsky.social personal best 🙌🍾
Stoked to be one of the recipients of the EFSD/Lilly Young Investigator Award for my project where I will investigate the role of impaired glycogenolysis &/or aberrant glycogen in glucose homeostasis! Thanks to @easdnews.bsky.social for the funding.
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
August 23, 2025 at 6:40 PM
Stoked to be one of the recipients of the EFSD/Lilly Young Investigator Award for my project where I will investigate the role of impaired glycogenolysis &/or aberrant glycogen in glucose homeostasis! Thanks to @easdnews.bsky.social for the funding.
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
Reposted by Dipsikha Biswas
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
August 21, 2025 at 2:28 PM
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
Reposted by Dipsikha Biswas
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 9, 2025 at 8:28 AM
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to share my article as part of the Journal Club series in @natrevendo.nature.com where I discuss about the emerging role of #glycogen #metabolism as an important #signaling molecule regulating energy homeostasis in adipose tissue.
nature.com/articles/s4157…
nature.com/articles/s4157…
July 8, 2025 at 7:54 PM
Happy to share my article as part of the Journal Club series in @natrevendo.nature.com where I discuss about the emerging role of #glycogen #metabolism as an important #signaling molecule regulating energy homeostasis in adipose tissue.
nature.com/articles/s4157…
nature.com/articles/s4157…
Reposted by Dipsikha Biswas
Frailty poses a major public health challenge, yet it is a poorly understood condition globally.
To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission.
Find out more ▶️ tinyurl.com/4zhkvt89
To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission.
Find out more ▶️ tinyurl.com/4zhkvt89
July 1, 2025 at 11:02 AM
Frailty poses a major public health challenge, yet it is a poorly understood condition globally.
To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission.
Find out more ▶️ tinyurl.com/4zhkvt89
To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission.
Find out more ▶️ tinyurl.com/4zhkvt89
Reposted by Dipsikha Biswas
Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.
guiding our junior colleagues. We wish her the best for her bright future!
.
July 1, 2025 at 8:24 PM
Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.
guiding our junior colleagues. We wish her the best for her bright future!
.
Reposted by Dipsikha Biswas
Last year in #ScienceRobotics, researchers followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit.
Learn more: scim.ag/46hifcU #ScienceMagArchives
Learn more: scim.ag/46hifcU #ScienceMagArchives
July 1, 2025 at 6:56 PM
Last year in #ScienceRobotics, researchers followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit.
Learn more: scim.ag/46hifcU #ScienceMagArchives
Learn more: scim.ag/46hifcU #ScienceMagArchives
Reposted by Dipsikha Biswas
🚨 We have two vacancies for PhD fellows:
- on ideological stereotypes supervised by me and
@robindevroe.bsky.social www.ugent.be/en/work/scie...
- on losers' consent supervised by @annakern.bsky.social
www.ugent.be/en/work/scie...
Join research group @gasparugent.bsky.social in beautiful Ghent
- on ideological stereotypes supervised by me and
@robindevroe.bsky.social www.ugent.be/en/work/scie...
- on losers' consent supervised by @annakern.bsky.social
www.ugent.be/en/work/scie...
Join research group @gasparugent.bsky.social in beautiful Ghent
June 4, 2025 at 8:17 AM
🚨 We have two vacancies for PhD fellows:
- on ideological stereotypes supervised by me and
@robindevroe.bsky.social www.ugent.be/en/work/scie...
- on losers' consent supervised by @annakern.bsky.social
www.ugent.be/en/work/scie...
Join research group @gasparugent.bsky.social in beautiful Ghent
- on ideological stereotypes supervised by me and
@robindevroe.bsky.social www.ugent.be/en/work/scie...
- on losers' consent supervised by @annakern.bsky.social
www.ugent.be/en/work/scie...
Join research group @gasparugent.bsky.social in beautiful Ghent
Reposted by Dipsikha Biswas
Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.
June 5, 2025 at 8:25 AM
Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.
Reposted by Dipsikha Biswas
Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice
Piperacillin, an FDA-approved beta-lactam, is effective at killing the Lyme disease–causing agent Borrelia burgdorferi.
scim.ag
May 16, 2025 at 7:20 PM
Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
The wonders that Basic science funding can lead to! What an achievement 👏
CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
May 17, 2025 at 9:10 AM
The wonders that Basic science funding can lead to! What an achievement 👏
Reposted by Dipsikha Biswas
Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.
May 16, 2025 at 6:35 PM
Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.
Reposted by Dipsikha Biswas
Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The SIK3-N783Y mutation is associated with the human natural short sleep trait | PNAS
Sleep is an essential component of our daily life. A mutation in human salt induced
kinase 3 (hSIK3), which is critical for regulating sleep durati...
www.pnas.org
May 5, 2025 at 8:08 PM
Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Dipsikha Biswas
“Science has no passport, no gender, no ethnicity, no political party.”
EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.
In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.
In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
May 6, 2025 at 11:26 AM
“Science has no passport, no gender, no ethnicity, no political party.”
EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.
In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.
In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
Reposted by Dipsikha Biswas
Towards optimizing #cancer therapy through a #microbiota lens @naturemetabolism.bsky.social www.nature.com/articles/s42...
The gut microbiome and cancer: from tumorigenesis to therapy - Nature Metabolism
This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes
www.nature.com
May 6, 2025 at 9:32 AM
Towards optimizing #cancer therapy through a #microbiota lens @naturemetabolism.bsky.social www.nature.com/articles/s42...
Reposted by Dipsikha Biswas
The expanding evidence base and new molecules in the new world of GLP-1 medicines. Beyond #T2D #obesity @naturerevdrugdisc.bsky.social
can01.safelinks.protection.outlook.com?url=https%3A...
can01.safelinks.protection.outlook.com?url=https%3A...
April 26, 2025 at 7:53 AM
The expanding evidence base and new molecules in the new world of GLP-1 medicines. Beyond #T2D #obesity @naturerevdrugdisc.bsky.social
can01.safelinks.protection.outlook.com?url=https%3A...
can01.safelinks.protection.outlook.com?url=https%3A...
Reposted by Dipsikha Biswas
Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.
Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance
Abstract. Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skele
academic.oup.com
April 25, 2025 at 1:40 PM
Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.
Reposted by Dipsikha Biswas
The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States
Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagg...
scim.ag
April 25, 2025 at 4:50 PM
The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO
Reposted by Dipsikha Biswas
The compounding of GLP-1 medicines, safety and efficacy, has been contentious. The courts are starting to opine #weightloss #obesity www.cnbc.com/amp/2025/04/...
Novo Nordisk scores major legal win that bars many compounded versions of Wegovy, Ozempic
Patients flocked to those Ozempic, Wegovy copycats when the branded drugs were in short supply, or if they didn't have insurance coverage for the treatments.
www.cnbc.com
April 25, 2025 at 8:28 PM
The compounding of GLP-1 medicines, safety and efficacy, has been contentious. The courts are starting to opine #weightloss #obesity www.cnbc.com/amp/2025/04/...
Reposted by Dipsikha Biswas
More evidence that hepatocyte gluconeogenic gene expression and glucose production are spatially and temporally plastic across the liver lobule, underscoring complexity of defining hepatic insulin resistance and glucose production on a whole-organ level www.nature.com/articles/s42...
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states - Nature Metabolism
The authors use single-cell analyses to demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis, highlighting the complexity of hepatic glucose homeostasis across states of feeding, fa...
www.nature.com
April 25, 2025 at 9:09 AM
More evidence that hepatocyte gluconeogenic gene expression and glucose production are spatially and temporally plastic across the liver lobule, underscoring complexity of defining hepatic insulin resistance and glucose production on a whole-organ level www.nature.com/articles/s42...