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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · 8d

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

www.biorxiv.org

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · 29d

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

www.science.org

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Sep 2

Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾

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Dipsikha Biswas @itsmedipsikha.bsky.social · Aug 23

Stoked to be one of the recipients of the EFSD/Lilly Young Investigator Award for my project where I will investigate the role of impaired glycogenolysis &/or aberrant glycogen in glucose homeostasis! Thanks to @easdnews.bsky.social for the funding.
www.europeandiabetesfoundation.org/recipients/e...

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Dipsikha Biswas @itsmedipsikha.bsky.social · Aug 23

Thank you!

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Dipsikha Biswas @itsmedipsikha.bsky.social · Aug 23

Thank you!

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Aug 21

Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science

www.europeandiabetesfoundation.org/recipients/e...

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Jul 9

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science

www.nature.com/articles/s41...

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Dipsikha Biswas @itsmedipsikha.bsky.social · Jul 8

Happy to share my article as part of the Journal Club series in @natrevendo.nature.com where I discuss about the emerging role of #glycogen #metabolism as an important #signaling molecule regulating energy homeostasis in adipose tissue.

nature.com/articles/s4157…

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Dipsikha Biswas @itsmedipsikha.bsky.social · Jul 5

Impaired #glycogen metabolism in the #brain is associated with tauopathies, like #Alzheimers

Surprise Discovery About Sugar in The Brain Could Help Fight Alzheimer's

Stores of glucose in the brain could play a much more significant role in the pathological degeneration of neurons than scientists realized, opening the way to new treatments for conditions like Alzhe...

www.sciencealert.com

Reposted by Dipsikha Biswas

The Lancet @thelancet.com · Jul 1

Frailty poses a major public health challenge, yet it is a poorly understood condition globally.

To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission.

Find out more ▶️ tinyurl.com/4zhkvt89

Promotional card for The Lancet Comment "Reorientating frailty in clinical practice, public health, and policy: the Lancet Commission on Frailty". Background image depicts an in-home nurse helping senior man walk through his hallway.

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Jul 1

Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.

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Reposted by Dipsikha Biswas

Science Magazine @science.org · Jul 1

Last year in #ScienceRobotics, researchers followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit.

Learn more: scim.ag/46hifcU #ScienceMagArchives

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Reposted by Dipsikha Biswas

Bram Wauters @bramwauters.bsky.social · Jun 4

🚨 We have two vacancies for PhD fellows:

- on ideological stereotypes supervised by me and
@robindevroe.bsky.social www.ugent.be/en/work/scie...

- on losers' consent supervised by @annakern.bsky.social
www.ugent.be/en/work/scie...

Join research group @gasparugent.bsky.social in beautiful Ghent

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Jun 5

Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.

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Reposted by Dipsikha Biswas

Science Magazine @science.org · May 16

Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.

Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1

A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice

Piperacillin, an FDA-approved beta-lactam, is effective at killing the Lyme disease–causing agent Borrelia burgdorferi.

scim.ag

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Dipsikha Biswas @itsmedipsikha.bsky.social · May 17

The wonders that Basic science funding can lead to! What an achievement 👏

Children's Hospital of Philadelphia @childrensphila.bsky.social · May 15

CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.

Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....

Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · May 16

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

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Reposted by Dipsikha Biswas

Eric Topol @erictopol.bsky.social · May 5

Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday
www.pnas.org/doi/10.1073/...

The SIK3-N783Y mutation is associated with the human natural short sleep trait | PNAS

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep durati...

www.pnas.org

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Reposted by Dipsikha Biswas

European Research Council (ERC) @erc.europa.eu · May 6

“Science has no passport, no gender, no ethnicity, no political party.”

EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.

In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.

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Reposted by Dipsikha Biswas

Daniel Drucker @danieljdrucker.bsky.social · May 6

Towards optimizing #cancer therapy through a #microbiota lens @naturemetabolism.bsky.social www.nature.com/articles/s42...

The gut microbiome and cancer: from tumorigenesis to therapy - Nature Metabolism

This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

www.nature.com

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Reposted by Dipsikha Biswas

Daniel Drucker @danieljdrucker.bsky.social · Apr 26

The expanding evidence base and new molecules in the new world of GLP-1 medicines. Beyond #T2D #obesity @naturerevdrugdisc.bsky.social

can01.safelinks.protection.outlook.com?url=https%3A...

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Reposted by Dipsikha Biswas

Sakamoto Lab @labsakamoto.bsky.social · Apr 25

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance

Abstract. Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skele

academic.oup.com

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Reposted by Dipsikha Biswas

Science Magazine @science.org · Apr 25

The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO

Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States

Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagg...

scim.ag

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Reposted by Dipsikha Biswas

Daniel Drucker @danieljdrucker.bsky.social · Apr 25

The compounding of GLP-1 medicines, safety and efficacy, has been contentious. The courts are starting to opine #weightloss #obesity www.cnbc.com/amp/2025/04/...

Novo Nordisk scores major legal win that bars many compounded versions of Wegovy, Ozempic

Patients flocked to those Ozempic, Wegovy copycats when the branded drugs were in short supply, or if they didn't have insurance coverage for the treatments.

www.cnbc.com

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