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Reposted by Kei Sakamoto

Sakamoto Lab @labsakamoto.bsky.social · 29d

The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.

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Reposted by Kei Sakamoto

Sakamoto Lab @labsakamoto.bsky.social · 29d

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

www.science.org

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Reposted by Kei Sakamoto

Eric Topol @erictopol.bsky.social · Jul 11

The gut hormone mimetic era in medicine is just getting started
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

www.nature.com

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Reposted by Kei Sakamoto

Juleen R. Zierath @juleenrzierath.bsky.social · Jul 11

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

www.nature.com

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Kei Sakamoto @keisakamoto.bsky.social · May 23

Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...

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Reposted by Kei Sakamoto

Sakamoto Lab @labsakamoto.bsky.social · May 16

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

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Reposted by Kei Sakamoto

Eric Topol @erictopol.bsky.social · Apr 20

The surprising result for a GLP-1 pill (orforglipron) is the magnitude of weight loss in a Phase 3 trial of participants with Type 2 diabetes. For still unexplained reasons, people with diabetes lose much less weight on GLP-1 drugs than those with obesity, w/o diabetes.

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Kei Sakamoto @keisakamoto.bsky.social · Apr 21

Th most-cited research papers of all time. A 1951 publication by US biochemist Oliver Lowry in the Journal of Biological Chemistry describing an assay to determine the amount of protein in a solution has been cited more than 350,000 times.

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Kei Sakamoto @keisakamoto.bsky.social · Apr 21

Eli Lilly announced positive results from a large clinical trial of its once-daily pill orforglipron in people with type 2 diabetes, while Pfizer announced last week it was halting development of its candidate after signs of liver injury in a trial participant.

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Kei Sakamoto @keisakamoto.bsky.social · Apr 18

Joan was a visionary and inspirational leader, researcher and generous mentor and friend. His legacy will stay forever.
@irbbarcelona.org

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Apr 18

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.

Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.

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Reposted by Kei Sakamoto

Science Magazine @science.org · Mar 26

President Donald Trump has nominated Susan Monarez, an infectious disease researcher and current acting director of the Centers for Disease Control and Prevention, to become the agency’s permanent leader. scim.ag/425J0xs

Trump’s new CDC pick ‘has her work cut out for her’

Susan Monarez, an expert in biosecurity and infectious disease, strikes some as a sensible choice to head the health agency—but some staffers there have raised concerns

scim.ag

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Reposted by Kei Sakamoto

Mark Cuban @mcuban.bsky.social · Mar 22

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

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Reposted by Kei Sakamoto

BrunetLab @brunetlab.bsky.social · Mar 22

Interested in aging?

Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨

Joint meeting with the Keystone Innate Immunity meeting!

#aging #immunity @keystonesymposia.bsky.social

www.keystonesymposia.org/conferences/...

Aging: Immune Function and Organ Health | Keystone Symposia

Join us at the Keystone Symposia on Aging: Immune Function and Organ Health, March 2026, in Banff, with field leaders!

www.keystonesymposia.org

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Reposted by Kei Sakamoto

Anna Krook @annakrook.bsky.social · Mar 21

The Strategic Research Programme in Diabetes at Karolinska Institutet and Umeå Univeristy is seeking a Programme Manager (based in Stockholm).

More information about the programme is here ki.se/en/srp-diabe...

and the link to the position is here ki.varbi.com/en/what:job/...

Please repost!

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Kei Sakamoto @keisakamoto.bsky.social · Mar 21

Thank you very much for this initiative and providing us with the opportunity to share our memories and stories. His legacy will stay forever. Visionary and inspirational leader, researcher and generous mentor and friend.

IRB Barcelona @irbbarcelona.org · Mar 21

Honoring Dr. Joan Guinovart—a visionary in science and an inspiration to many. Share your memories, stories, and gratitude to celebrate his remarkable legacy.

Let’s keep his spirit alive:

➡️ www.irbbarcelona.org/en/guinovart

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Kei Sakamoto @keisakamoto.bsky.social · Mar 18

Many congrats Elton. Hope our manuscript is the next success!!

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Reposted by Kei Sakamoto

Eric Topol @erictopol.bsky.social · Mar 13

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...

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Reposted by Kei Sakamoto

Daniel Drucker @danieljdrucker.bsky.social · Mar 12

A partner for Petrelintide #obesity www.globenewswire.com/news-release...

Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as a future foundational therapy for people with overweight and obesity

Company announcement – No. 4 / 2025 Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as...

www.globenewswire.com

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Kei Sakamoto @keisakamoto.bsky.social · Mar 12

"Glycogen drives tumour initiation and progression in lung adenocarcinoma"

Nature Metabolism @natmetabolism.nature.com · Mar 11

Glycogen drives tumour initiation and progression in lung adenocarcinoma

Nature Metabolism, Published online: 11 March 2025; doi:10.1038/s42255-025-01243-8Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

bit.ly

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Reposted by Kei Sakamoto

Sakamoto Lab @labsakamoto.bsky.social · Mar 11

Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK

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Reposted by Kei Sakamoto

Science Magazine @science.org · Mar 11

A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.

Learn more: scim.ag/3R59fPe (THREAD 🧵)

Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.

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Reposted by Kei Sakamoto

Sakamoto Lab @labsakamoto.bsky.social · Mar 10

Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day!
Happy International Women's Day!
#WomensDay2025 #LatePost

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Reposted by Kei Sakamoto

Science Magazine @science.org · Mar 8

Currently, NIH's Center for Scientific Review reviews 66,000 grant applications a year, with panels run by NIH’s separate institutes reviewing the rest.

Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG

NIH will eliminate many peer review panels and lay off some scientists overseeing them

scim.ag

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Reposted by Kei Sakamoto

Science Magazine @science.org · Mar 8

"The academic structure … makes planning for a family feel like an impossible luxury."

In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay

As women in academia, having children can feel impossible. Talking about it makes us feel less alone

The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write

scim.ag

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Kei Sakamoto @keisakamoto.bsky.social · Mar 6

Hope you just us next time:)

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