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Juleen R. Zierath @juleenrzierath.bsky.social · 9d

Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social

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Juleen R. Zierath @juleenrzierath.bsky.social · 15d

Not too late to register for Keystone Symposia meetings- great networking opportunities:
Obesity Therapeutics: Unlocking Benefits & Minimizing Side Effects keystonesymposia.org/conferences/...
Cardiometabolism in Health & Disease keystonesymposia.org/conferences/...
Keystone Resort, Jan 26–29, 2026

Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects | Keystone Symposia

Join us at the Keystone Symposia on Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects, January 2026, in Keystone, with field leaders!

keystonesymposia.org

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Juleen R. Zierath @juleenrzierath.bsky.social · 23d

Celebrating the 60th Anniversary of @diabetologiajnl.bsky.social Diabetologia - the flagship journal of @easdnews.bsky.social the European Association for the Study of Diabetes! Thanks to our colleagues at the American Diabetes Association and Diabetes Care AND it’s editor-in-chief - Steve Kahn

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Juleen R. Zierath @juleenrzierath.bsky.social · Sep 3

The Zierath/Krook/Wallberg lab celebrated our current & former fellows & students at Nobel Forum with a fantastic symposium on insulin action & metabolism. Grateful for all who traveled far & near to be with us to focus on science, inclusion, and innovation!

photographer: Stefan Zimmerman

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Juleen R. Zierath @juleenrzierath.bsky.social · Sep 2

The Zierath/Krook/Wallberg lab celebrated our current & former fellows and students at Nobel Forum sept 1 with a fantastic symposium on insulin action & metabolism. Grateful for all the trainees who traveled far & near to be with us to focus on science, inclusion, and innovation!

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Juleen R. Zierath @juleenrzierath.bsky.social · Jul 14

Visited family this past weekend and one of my siblings has this posted in the front yard! I completely agree with each and every point! Happy summer!

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Juleen R. Zierath @juleenrzierath.bsky.social · Jul 11

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

www.nature.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Jul 9

Congratulations team! 👍
This will be of interest for muscle physiologists #MyoBlue @myoblue.bsky.social

Anna Krook @annakrook.bsky.social · Jul 9

A human specific lncRNA important for ribosomal biogenesis in skeletal muscle- reduced in people with type 2 diabetes.Latest from the team! @ilkesen.bsky.social @juleenrzierath.bsky.social Science Advances www.science.org/doi/10.1126/...

Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis

TMEM9B-AS1, down-regulated in type 2 diabetes, regulates ribosomal biogenesis in muscle by promoting IGF2BP1-MYC mRNA interaction.

www.science.org

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Juleen R. Zierath @juleenrzierath.bsky.social · Jul 8

Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise. Great teamwork w/ Amy Ehrlich, Kirstin MacGregor & Ste Ashcroft at al! #MyoBlue @myoblue.bsky.social
www.pnas.org/doi/10.1073/...

HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise | PNAS

The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated ...

www.pnas.org

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Juleen R. Zierath @juleenrzierath.bsky.social · Jul 3

Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis.

Congrats to Jon Smith Brendan Gabriel Nico Pillon & team!

www.sciencedirect.com/science/arti...

Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: insights from in vitro analysis

Physical activity promotes health, whereas inactivity is associated with metabolic impairment. The transcription factor nuclear receptor subfamily 4 g…

www.sciencedirect.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Jun 29

Our latest!
Great team effort! We found that in men & women with type 2 diabetes, afternoon high-intensity interval exercise appears to be more effective than morning high-intensity interval exercise for maintaining glucose management. @diabetologiajnl.bsky.social
link.springer.com/10.1007/s001...

Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes - Diabetologia

Aims/hypothesis The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes undertaking high-intensity interval exercise. Additionally, th...

link.springer.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Jun 13

Attending Keystone Symposia Board of Directors meeting @keystonesymposia.bsky.social planning for future programs & initiatives.

Keystone Symposia serves as a catalyst for the advancement of biomedical & life sciences by connecting scientists within & across disciplines at conferences & workshops

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Juleen R. Zierath @juleenrzierath.bsky.social · Jun 7

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science

www.sciencedirect.com/science/arti...

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

www.sciencedirect.com

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Juleen R. Zierath @juleenrzierath.bsky.social · May 30

Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise-
New study by Paola Pinto-Hernandez reveals training-induced molecular mediators in the response and adaptation to training.
www.sciencedirect.com/science/arti...

Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice

It remains unclear whether the adaptive response to different exercise models is mediated by extracellular vesicle (EV) microRNAs (miRNAs) released fr…

www.sciencedirect.com

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Juleen R. Zierath @juleenrzierath.bsky.social · May 27

Highlighting our latest research.
Deconvoluting insulin signaling in human skeletal muscle.
www.news-medical.net/news/2025052...

Scientists discover unique molecular fingerprints of insulin resistance

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

www.news-medical.net

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Juleen R. Zierath @juleenrzierath.bsky.social · May 27

Personalized molecular signatures of insulin resistance and type 2 diabetes.

Great collaboration with @annakrook.bsky.social and @adeshmukh.bsky.social

A comprehensive clinically focused study of insulin signaling in skeletal muscle. 💪

Online today!

www.sciencedirect.com/science?_ob=...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

www.sciencedirect.com

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Juleen R. Zierath @juleenrzierath.bsky.social · May 19

Delighted to attend Genomic Mechanisms of Disease conference! The 31st Science Cluster conference, "Genomic Mechanisms of Disease" brings together experts to discuss research on the genomic influences underlying various diseases. Thx to novonordiskfonden.dk/en/projects/...
@novo-nordisk.bsky.social

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Juleen R. Zierath @juleenrzierath.bsky.social · Apr 30

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

www.sciencedirect.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Apr 28

Our latest! Great collaborative effort with David Rizo-Roca & John Henderson!
Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes - Journal of Internal Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

<em>Journal of Internal Medicine</em> | Wiley Online Library

Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that a...

onlinelibrary.wiley.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Apr 24

Congratulations to Mikael Ryden @ki.se @srpdiabetes.bsky.social
Looking forward to this lecture!!

European Association for the Study of Diabetes @easdnews.bsky.social · Apr 24

🏆It is with great honour that we announce Prof. Mikael Rydén as the recipient of the 40th EASD Camillo Golgi Prize, recognising his groundbreaking work in adipose tissue biology and diabetes complications.

Congratulations, Prof. Rydén!👏

This prize is generously supported by Novo Nordisk.

Promotional banner for the 61st EASD Annual Meeting 2025 in Vienna, highlighting Prof. Mikael Rydén as winner of the 40th EASD Camillo Golgi Prize for his outstanding diabetes research, with his photo in a blue circle above an image of the Vienna Giant Ferris Wheel.

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Juleen R. Zierath @juleenrzierath.bsky.social · Mar 17

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

www.nature.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Mar 16

Yes, in fact I do!!

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Juleen R. Zierath @juleenrzierath.bsky.social · Mar 11

If you missed Metabolism Day #MD25, @cbmr.science you can catch the talks here! m.youtube.com/watch?v=oUi9...

Metabolism Day 2025

YouTube video by CBMR at the University of Copenhagen

m.youtube.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Mar 11

Happening now! 👍👇

NNF Center for Basic Metabolic Research @cbmr.science · Mar 11

🎉Metabolism Day kicks off in just a minute at 9:00 CET!

Tune in on the YouTube livestream, below:

www.youtube.com/live/oUi9JU_...

Metabolism Day 2025

YouTube video by CBMR at the University of Copenhagen

www.youtube.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Mar 9

Just wrapping up this Nobel Prize Dislogue Tokyo on the “Future of Life” @nobelprize.bsky.social
Very interesting discussions about opportunities and challenges for all to consider #NobelPrize catch up on the program online
More info here: www.nobelprize.org/events/nobel...

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