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Reposted by Astbury Biostructure Laboratory

Sjors Scheres @sjorsscheres.bsky.social · 3d

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!

#OpenSoftwareAcceleratesScience

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Astbury Biostructure Laboratory

Oli Clarke @olibclarke.bsky.social · Aug 22

Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Aug 11

🚨 We’re hiring! 🚨

We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL!

You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM).

Any questions? Get in touch!

jobs.leeds.ac.uk/Vacancy.aspx...

Job Opportunity at University of Leeds: Correlative Imaging Scientist

Are you a creative postdoctoral-scientist keen to explore novel in-situ biology with cryogenic electron tomography? Do you have a background in imaging technologies and/or image processing?We are look...

jobs.leeds.ac.uk

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Jul 21

Delighted to see our publication with industry partners out! 🎉
Huge shoutout to @jbrwhite.bsky.social and @oksana-degtjarik.bsky.social for their contributions to the structural work!
Many thanks to @chingshinhuang.bsky.social & the whole team for an excellent collaboration!
#CryoEM #drugdiscovery

Ching-Shin Huang @chingshinhuang.bsky.social · Jul 19

Working with @astbury-bsl.bsky.social, we report cryo-EM structures of CD163 in its apo state and in complex with haptoglobin–hemoglobin (HpHb), and propose a framework of how CD163-mediated endocytosis clears different isoforms of HpHb. Please check it out on @plosbiology.org!

PLOS Biology @plosbiology.org · Jul 15

The #macrophage CD163 receptor clears free #hemoglobin in the bloodstream by binding the HpHb complex. The #cryoEM structure of CD163-HpHb complex, by @chingshinhuang.bsky.social &co, reveals how CD163-mediated endocytosis clears different HpHb isoforms @plosbiology.org 🧪 plos.io/4nNBbGI

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Reposted by Astbury Biostructure Laboratory

Robin Bon @rsbon.bsky.social · Jul 13

We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation".

www.biorxiv.org/content/10.1...

Structure of human TRPC5 in complex with the plant nature product (-)-englerin A

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Jul 11

🚀 Less than a week left to apply for our ‘Introduction to Single-Particle Cryo-EM 2025’

Course Dates: 1th - 4th September 2025
Application Deadline: 17th July 2025

astbury.leeds.ac.uk/facilities/w...

Introduction to Single-Particle Cryo-EM - September 2025 : The Astbury Centre for Structural Molecular Biology - "Understanding Life in Molecular Detail"

Course overview This in-person beginners’ course is aimed at PhD students and postdoctoral researchers who are new to cryo-electron microscopy (cryo-EM) and plan to incorporate it into their research....

astbury.leeds.ac.uk

Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Jun 18

🚨 Applications now open!
Join us in Leeds for the Wellcome-MRC Cryo-EM Training Course
📅 1–4 Sept 2025 | 🧊 Beginners tailored
🔬 Hands-on single-particle cryo-EM
👉 More info and to apply: forms.office.com/e/QHYmbcsZ33

Microsoft Forms

forms.office.com

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Jun 2

A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!

Iso Hirst @isobelhirst.bsky.social · Jun 2

I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩

www.sciencedirect.com/science/arti...

Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA

Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromolecules without requiring cry…

www.sciencedirect.com

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · May 20

Oops—wrong tag earlier! Meant to tag @richjallen.bsky.social Thanks again for the brilliant talk!

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · May 19

Wonderful #PintOfScience evening with @maddie-gilbert.bsky.social and @richardallenart.bsky.social making sense of memory loss! The memory test results may already have slipped our minds…😅
Huge thanks to our own @c-hawksworth.bsky.social for helping organise such a great event!🍺

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Reposted by Astbury Biostructure Laboratory

Bijvoet Centre @bijvoet-centre.bsky.social · May 12

Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · May 8

Haha, baby FastBlot comes with a built-in northern narrator? 🤣

Astbury Biostructure Laboratory @astbury-bsl.bsky.social · May 7

The perfect gift doesn’t exi… Oh wait!

Those tiny replicas of our Titan Krios microscopes are absolutely adorable! 🥹❄️
Thank you so much @snowentific.bsky.social!
Wishing you all the best in your next adventure - you will be missed!

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Reposted by Astbury Biostructure Laboratory

Ben Engel @cellarchlab.com · May 7

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

Philippe Van der Stappen @phaips.vd.st · May 6

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

Welcome to TomoGuide

A step-by-step Cryo-ET guide

tomoguide.github.io

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 25

The full paper here www.nature.com/articles/s41...

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

www.nature.com

Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 25

Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 24

Huge shout out to @jenkinsjj.bsky.social for his excellent talk on the #cryoET structure of Tau filaments from human brain tissue at CCPEM Spring Symposium in Nottingham! #cryo-EM @diamondlightsource.bsky.social @ccpem.bsky.social

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Reposted by Astbury Biostructure Laboratory

Instruct-ERIC @instruct-eric.bsky.social · Apr 24

It's great to be at the CCPEM conference in Nottingham this week, with talks from many Instruct facilities including @astburycentre.bsky.social, @astbury-bsl.bsky.social, @diamondlightsource.bsky.social, and @ox.ac.uk!

Find out more about the Instruct-UK centre - instruct-eric.org/centres/inst...

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 15

Grateful to @wellcometrust.bsky.social for funding 💙

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 15

Another week, another training course wrapped up ✅
Huge thanks to our fantastic participants for sticking with us through the reschedule, and to our amazing lecturers & tutors for making it a success: @leicstructbio.bsky.social @diamondlightsource.bsky.social @uofglasgow.bsky.social
& Birkbeck, UoL

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Reposted by Astbury Biostructure Laboratory

Ste Muench @stemuench.bsky.social · Apr 10

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

Charlie Scarff @scarfflab.bsky.social · Apr 9

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

www.nature.com

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Apr 10

🔬 Exciting to see our custom time-resolved cryo-EM device featured in Nature!
A groundbreaking look at the swinging lever mechanism of myosin in action!
Huge congrats to @scarfflab.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social and everyone involved!

#cryoEM

Charlie Scarff @scarfflab.bsky.social · Apr 9

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

www.nature.com

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Reposted by Astbury Biostructure Laboratory

Structura Biotechnology @structurabio.bsky.social · Apr 9

#CryoSPARC v4.7 is out! 🚀
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates

#cryoEM

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Mar 18

🔬Sibling rivalry alert!
Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡
Exciting times ahead!

Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌
#cryoEM #cryoET

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Reposted by Astbury Biostructure Laboratory

Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

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