Charlie Scarff
@scarfflab.bsky.social
400 followers
380 following
11 posts
Structural Biologist @AstburyCentre @LICAMM University of Leeds
#Myosin #Muscle #Cardiomyopathy #cryoEM #MassSpectrometry
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Charlie Scarff
@scarfflab.bsky.social
· Jun 24
Charlie Scarff
@scarfflab.bsky.social
· Jun 16
Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com
www.findaphd.com
Reposted by Charlie Scarff
Charlie Scarff
@scarfflab.bsky.social
· Apr 9
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
Charlie Scarff
@scarfflab.bsky.social
· Feb 17
Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin...
www.biorxiv.org
Reposted by Charlie Scarff
Charlie Scarff
@scarfflab.bsky.social
· Nov 19
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
Reposted by Charlie Scarff
Charlie Scarff
@scarfflab.bsky.social
· Nov 19
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
www.findaphd.com
Charlie Scarff
@scarfflab.bsky.social
· Nov 19
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
www.findaphd.com
Charlie Scarff
@scarfflab.bsky.social
· Nov 19
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
Charlie Scarff
@scarfflab.bsky.social
· Nov 13
Cheney PhD : The Astbury Centre for Structural Molecular Biology
The Cheney Scholarship 4-year PhD Scheme in in situ structural biology Applications are now invited for up to 4 new scholarships, commencing in October 2025. The application deadline is Tuesday 3rd De...
astbury.leeds.ac.uk
Charlie Scarff
@scarfflab.bsky.social
· Nov 13
Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM
Myosins are essential for producing force and movement in cells through their interactions with F-actin. Generation of movement is proposed to occur through structural changes within the myosin motor ...
biorxiv.org