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Bijvoet Centre @bijvoet-centre.bsky.social · Jul 4

Today, the Dutch nodes of the European Life and Medical Science Research Infrastructures discuss their strategy and sustainability for the future at @naturalis.bsky.social in Leiden. We are representing @instruct-eric.bsky.social and structural biology.

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Ezgi Karaca @ezgikaraca.bsky.social · Jun 11

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT!

Course website: meetings.embo.org/event/25-bio...

Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social

Location: www.ibg.edu.tr

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Bijvoet Centre @bijvoet-centre.bsky.social · Jun 11

Automated detection of macromolecules in cryo-ET data of cellular samples is challenging. Here, we introduce "pytom-match-pick", a GPU-accelerated, open-source interface that improves the efficiency and accuracy of macromolecule detection in cellular contexts: www.sciencedirect.com/science/arti...

pytom-match-pick: A tophat-transform constraint for automated classification in template matching

Template matching (TM) in cryo-electron tomography (cryo-ET) enables in situ detection and localization of known macromolecules. However, TM faces cha…

www.sciencedirect.com

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Bijvoet Centre @bijvoet-centre.bsky.social · Jun 10

The artists from Sensu have worked with @thermofishersci.bsky.social and made this beautiful video on the applications of structural biology: www.youtube.com/watch?v=m3QA...

Check out our YouTube channel for videos we made with Sensu about our work: www.youtube.com/@BijvoetCenter

Launching Thermo Fisher Scientific's Krios 5 Cryo-TEM | A New Era in Electron Microscopy

YouTube video by Sensu

www.youtube.com

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Eva Bertosin @thedneva.bsky.social · May 13

Indeed I'm happy to be here! Looking forward to great science 💪🏼

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Bijvoet Centre @bijvoet-centre.bsky.social · May 14

We are happy to host, on behalf of the Netherlands, the Council meeting of Instruct-ERIC (@instruct-eric.bsky.social), the European Research Infrastructure Consortium for structural biology. If you are interested in accessing state of the art structural biology technology, see instruct-eric.org.

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Bijvoet Centre @bijvoet-centre.bsky.social · May 13

We are very happy to have Christoph Müller from the EMBL (@embl.org) as the final speaker of the joint session of Instruct-ERIC (@instruct-eric.bsky.social) and the Bijvoet Centre at the 2025 Bijvoet Symposium!

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Claudia Alen Amaro @claudialen.bsky.social · May 13

Delighted to be in Utrecht to learn from our users in the Netherlands, we can always do better!!

@utrechtuniversity.bsky.social @nkinl.bsky.social @necen.bsky.social

Instruct-ERIC @instruct-eric.bsky.social · May 13

Delighted to kick off the Instruct-ERIC Minisymposium I’m the Bijvoet Annual meeting in Utrecht today, with @claudialen.bsky.social!

instruct-eric.org/centres/inst...

@nkinl.bsky.social @utrechtuniversity.bsky.social @unileiden.bsky.social

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Instruct-ERIC @instruct-eric.bsky.social · May 13

The next speaker this afternoon is Michael Leung of @hubrechtinstitute.bsky.social, who conducted Cryo-EM studies at NeCEN in @unileiden.bsky.social through Instruct!

instruct-eric.org/centre/necen...

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Bijvoet Centre @bijvoet-centre.bsky.social · May 12

Since this month, Eva Bertosin (@thedneva.bsky.social) has joined the Bijvoet Centre, bringing her expertise on biophysics and DNA origami. Welcome Eva!

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Bijvoet Centre @bijvoet-centre.bsky.social · May 12

Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!

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Bijvoet Centre @bijvoet-centre.bsky.social · May 12

Great to have almost the entire Bijvoet Centre together for our 2025 Bijvoet Symposium! Looking forward to a lot of exciting science!

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Reposted by Bijvoet Centre

Alexandre Bonvin @amjjbonvin.bsky.social · May 7

The manuscript describing the new modular version of HADDOCK is finally available as a preprint! The result of a team work over several years, supported by @bioexcelcoe.bsky.social @bijvoet-centre.bsky.social @esciencecenter.bsky.social - www.biorxiv.org/content/10.1...

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Joost Snijder @joostsnijder.bsky.social · Apr 29

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife:
elifesciences.org/articles/101...

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Bijvoet Centre @bijvoet-centre.bsky.social · Apr 17

We are very happy to host Max Bonomi (@bonomimax.bsky.social) from the Institute Pasteur (@pasteur.fr) for a Bijvoet Seminar about structural and dynamic biology with integrative approaches.

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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Apr 17

#GBMLunch on April 23!
Speaker: Tzviya Zeev Ben Mordeha
@tzviyazbm.bsky.social from @bijvoet-centre.bsky.social

Title: Cryo-EM single particle analysis meets cryo-ET at the sperm tail
Chair: Cristina Paulino from
@uniheidelberg.bsky.social

Organized by the GBM Study Group "Structural Biology"

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Bijvoet Centre @bijvoet-centre.bsky.social · Apr 11

In this recent publication, we used an Orbitrap Astral mass spectrometer to rapidly analyze plasma glycoproteins, identifying over 3000 glycoPSMs in 40 minutes, with potential for high-throughput clinical applications: www.nature.com/articles/s41...

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer - Nature Communications

While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for N-glycopeptides, nGlycoDIA, ena...

www.nature.com

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Reposted by Bijvoet Centre

Ioannis Skalidis @johnskal.bsky.social · Mar 23

The first project I worked on, right after joining @bijvoet-centre.bsky.social!

cryoEM papers @cryoempapers.bsky.social · Mar 20

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus www.biorxiv.org/content/10.1101/2025.03.19.643997v1 #cryoem

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Albert Heck @hecklab.bsky.social · Mar 21

Interested in advanced therapeutics such as mRNA? See the latest work of Evolène Deslignière, doi.org/10.1016/j.om..., in collaboration with Pfizer, using innovative mass spectrometry & photometry @bijvoet-centre.bsky.social to obtain precision measurements on mRNA purity & structural integrity

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Friedrich Förster @fridof.bsky.social · Mar 20

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social.
www.biorxiv.org/content/10.1...

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

Reactive oxygen species (ROS) pose a significant threat to biological molecules, prompting organisms to develop systems that buffer oxidative stress and contain iron, which otherwise amplifies ROS pro...

www.biorxiv.org

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Bijvoet Centre @bijvoet-centre.bsky.social · Mar 20

Exciting Bijvoet Seminar by Marie-Eve Aubin-Tam from @tudelft.bsky.social on the engineering of bioinspired and living materials!

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Bijvoet Centre @bijvoet-centre.bsky.social · Mar 20

We congratulate Markus Weingarth of our #NMR spectroscopy group here at @utrechtuniversity.bsky.social with the recent award of a new #NWO funded project to tackle antibiotic toxicity.

www.uu.nl/en/news/cons...

Consortium led by Markus Weingarth awarded €1.5 Million to tackle antibiotic toxicity

Fundamentally understanding why some antibiotics turn out to be toxic is now a major step closer, thanks to a €1.5 million grant awarded to biochemist Markus Weingarth.

www.uu.nl

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Albert Heck @hecklab.bsky.social · Mar 15

Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...

rdcu.be

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Bijvoet Centre @bijvoet-centre.bsky.social · Mar 6

In this recent study, we used liposomes with E. coli lysates to mimic cellular crowding. We were able to achieve physiological macromolecular crowding levels, creating a platform that enables the controlled study of physiological crowding effects.

pubs.acs.org/doi/10.1021/...

Liposome-Encapsulated Escherichia coli Lysates to Reconstitute Intracellular Macromolecular Crowding Effects

Intracellular macromolecular crowding impacts biomacromolecule behavior, including oligomerization, phase separation, and diffusion. However, understanding crowding effects in cells is challenging as ...

pubs.acs.org

Reposted by Bijvoet Centre

Tzviya Zeev-Ben-Mordehai @tzviyazbm.bsky.social · Feb 28

I am honoured to receive a Vici grant from the Dutch Research Council to study sperm functional maturition at the female reproductive tract and to study how sperm establish interaction with an egg

www.uu.nl/en/news/nine...

Nine Utrecht-based researchers receive Vici-grant

The Dutch Research Council (NWO) has awarded Vici grants to nine Utrecht researchers.

www.uu.nl

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