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Reposted by Albert Heck

Ruth Huttenhain @rhuttenhain.bsky.social · 6d

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc

Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs

postdocs.stanford.edu

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Albert Heck @hecklab.bsky.social · 6d

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

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Reposted by Albert Heck

Joost Snijder @joostsnijder.bsky.social · 7d

We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.

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Albert Heck @hecklab.bsky.social · 19d

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry

Heck and colleagues developed a mass photometry-based method for accurate and fast mass determination of plasmid DNA. Conventional mass photometry methods are not applicable for large DNA particles; h...

www.cell.com

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Albert Heck @hecklab.bsky.social · 20d

Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques

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Albert Heck @hecklab.bsky.social · Sep 5

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics www.mcponline.org/article/S153.... See this work of @tkadava.bsky.social @utrechtuniversity.bsky.social artistically interpreted

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Albert Heck @hecklab.bsky.social · Sep 4

Great line-up

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Albert Heck @hecklab.bsky.social · Sep 4

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

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Reposted by Albert Heck

Vadim Demichev @vadim-demichev.bsky.social · Sep 2

www.biorxiv.org/content/10.1...

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics

Quantitative mass spectrometry (MS)-based proteomics has become a streamlined technology with a wide range of usage. Many emerging applications, such as single-cell proteomics, spatial proteomics of t...

www.biorxiv.org

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Reposted by Albert Heck

Ying Ge @yingge2121.bsky.social · Aug 29

Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at #TDP2025👍👏😀

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Reposted by Albert Heck

Ying Ge @yingge2121.bsky.social · Aug 26

#TDP2025 @proteoforms.bsky.social a great opening session with fantastic talks! @nlkproteomics.bsky.social @joelooucla.bsky.social @hecklab.bsky.social @metamorpheus.bsky.social 👍thanks Hartmut for organizing the conference! 👏

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Reposted by Albert Heck

Lorne Proteins @lorneproteins.bsky.social · Aug 21

🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞

February 8–12, 2026

Register here: www.lorneproteins.org

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Albert Heck @hecklab.bsky.social · Aug 18

Nice interview with star PhD Shelley!

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Reposted by Albert Heck

IonOpticks @ionopticks.bsky.social · Aug 17

New plasma glycoproteomics method out of the @hecklab.bsky.social uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs.

bit.ly/45bDXhv

Revolutionising plasma glycoproteomics with Orbitrap Astral and narrow-window DIA - IonOpticks

Jager et al.'s study into plasma glycoproteomics uses a 25 cm x 75 μm IonOpticks Aurora Ultimate 25x75 UHPLC column.

bit.ly

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Albert Heck @hecklab.bsky.social · Aug 13

Wish I could!

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Reposted by Albert Heck

Tereza Kadavá @tkadava.bsky.social · Aug 4

🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

www.mcponline.org

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Reposted by Albert Heck

Tereza Kadavá @tkadava.bsky.social · Aug 4

We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target.
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert

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Reposted by Albert Heck

Vanessa Linke @massspecvanili.bsky.social · Jul 31

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

tinyurl.com

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Reposted by Albert Heck

Ardem Patapoutian @ardemp.bskyverified.social · Jul 31

confession: I often get excited by n=1 results.

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Reposted by Albert Heck

maxquant.bsky.social @maxquant.bsky.social · Jul 28

Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(@hecklab.bsky.social‬), Kelly Stecker, Noortje de Haan & Ron Heeren.
And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).

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Reposted by Albert Heck

Lorne Proteins @lorneproteins.bsky.social · Jul 25

📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org

A cartoon image of a beach with a banner that reads "save the date!" 8th-12th February, 2026, Victoria, Australia. Lorne Proteins 2026.

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Reposted by Albert Heck

Sarafan ChEM-H @stanford-chemh.bsky.social · Jul 15

"You can literally lose who you are."

Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:

‘You can literally lose who you are’

Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them.

news.stanford.edu

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Reposted by Albert Heck

KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · Jul 10

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

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Reposted by Albert Heck

Thomas Arnesen @natmachinery.bsky.social · Jul 1

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

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Reposted by Albert Heck

UW–Madison School of Pharmacy @uwmadpharmacy.bsky.social · Jun 16

Why is cocaine so addictive? A new study from Professor Lingjun Li (@liresearch.bsky.social) reveals that it’s not just about dopamine — neuropeptides across the brain play a key role.

These insights could lead to better addiction treatments. Learn how: pharmacy.wisc.edu/2025/03/22/u...

Unlocking Cocaine’s Grip on the Brain - School of Pharmacy

Professor Lingjun Li and lab members reveal the crucial role of neuropeptides in cocaine addiction, paving the way for novel therapies.

pharmacy.wisc.edu

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