Lightnews — Scholar-powered news

Reposted by Tereza Kadavá

Albert Heck @hecklab.bsky.social · 6d

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

1 5 12

Tereza Kadavá @tkadava.bsky.social · Sep 4

Excited to see the C4BP in action. 🕷️
Check out the short movie by Sensu about our work from @hecklab.bsky.social lab.

Albert Heck @hecklab.bsky.social · Sep 4

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

4

Reposted by Tereza Kadavá

Vanessa Linke @massspecvanili.bsky.social · Aug 25

Last week to apply!

Vanessa Linke @massspecvanili.bsky.social · Jul 31

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

tinyurl.com

2

Tereza Kadavá @tkadava.bsky.social · Aug 4

Thanks Johannes!

Tereza Kadavá @tkadava.bsky.social · Aug 4

We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target.
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert

1 5

Tereza Kadavá @tkadava.bsky.social · Aug 4

🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

www.mcponline.org

2 5 9

Reposted by Tereza Kadavá

peterslab (BIOCEV,CZ) @peterslab1.bsky.social · Jun 25

Free structural MS hands-on workshop @ BIOCEV (CZ)

📅 Sept 15–19, 2025

For PhDs, postdocs & undergrads (CZ/SK)

HDX-MS, native MS, cross-linking, high-res MS, data processing

Apply by July 31 → bit.ly/3HNyzIg

@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social

7 10

Reposted by Tereza Kadavá

SCIEX @sciex.bsky.social · Jun 16

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics!

🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18!

🔗 Full show agenda 👉 bit.ly/3HcA6Hw

#SkepticsWelcome #ZenoTOF8600

4 9

Reposted by Tereza Kadavá

Albert Heck @hecklab.bsky.social · Jun 11

It has been nice to contribute to this nice piece of work together with @tkadava.bsky.social and @mattevilab.bsky.social

1 3

Tereza Kadavá @tkadava.bsky.social · Jun 4

Spiders from our blood 🕷️
Excited to present our work with @hecklab.bsky.social at #ASMS2025 WP 611.

3 14

Reposted by Tereza Kadavá

Laura Pérez @lperezpaneda.bsky.social · May 29

Excited to share our new preprint on archaeal proteases boosting reads in de novo antibody sequencing!

Team effort with @tkadava.bsky.social @tshamorkina.bsky.social and @hecklab.bsky.social

PastelBio @pastelbio.bsky.social · May 29

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont...

---
#proteomics #prot-preprint

5 6

Tereza Kadavá @tkadava.bsky.social · May 29

Check out our new preprint on combining archeal proteases with hybrid fragmentation to streamline de novo antibody sequencing!
Joined effort with @lperezpaneda.bsky.social, @tshamorkina.bsky.social, and @hecklab.bsky.social

PastelBio @pastelbio.bsky.social · May 29

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont...

---
#proteomics #prot-preprint

5 7

Reposted by Tereza Kadavá

PastelBio @pastelbio.bsky.social · May 29

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont...

---
#proteomics #prot-preprint

3 7