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Reposted by Iso Hirst

Harry M. Williams @harrywilliams.bsky.social · 21d

❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 21d

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification https://www.biorxiv.org/content/10.1101/2025.09.14.676144v1

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Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Iso Hirst @isobelhirst.bsky.social · 28d

Thanks 🤩

Iso Hirst @isobelhirst.bsky.social · 28d

I submitted my thesis today!!! 4 years of work in 1 pdf 🤯

Screenshot of thesis submission portal with celebratory emojis

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Iso Hirst @isobelhirst.bsky.social · Aug 19

Keeping me company whilst I write 🐓 #phd #chicken

A black and white hen on a table outside

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Sue @cameratrapsue.bsky.social · Aug 13

Bonjour, Madame Bear.

Bears must be my spirit animal as I often think or dream about them, then I either see one in person or on camera card, usually within a few hours.

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Amy Devlin @amydevlin.bsky.social · Jul 27

Michelle Agyemang takes the trophy for best young player of the tournament, and well deserved!

#England would not be in this final without her magic.

#WOSO #WEURO #EURO2025 #WEURO2025 #FOOTBALL

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UEFA Women’s EURO 2025 @weuro2025bot.bsky.social · Jul 25

Lending Keira Walsh a helping hand to make a fan’s dream come true 🤝🥹

#WEURO2025 || #Lionesses

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Iso Hirst @isobelhirst.bsky.social · Jul 25

Nice!!

Nikolai Slavov @slavov-n.bsky.social · Jul 24

bioRxiv has a dedicated section for negative results.

Use it.

Share negative results.
Your colleagues will appreciate it.

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womensartbluesky.bsky.social @womensartbluesky.bsky.social · Jul 24

Angélique-Marguerite du Coudray was a famous 18th century French midwife who designed various teaching aids to train midwives about anatomy and obstetrics. Her work saved many lives in the age #WomensArt

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The Women's Game @womensgamemib.bsky.social · Jul 20

The Euro semi-final stage is set. Who is winning it all? 🏆

📸: WEURO2025

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Saloni @scientificdiscovery.dev · Jul 21

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good!

There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...

AlphaFold - A practical guide

www.ebi.ac.uk

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Stand Up for Science! @standupforscience.bsky.social · Jun 20

Trans youth deserve healthcare, not courtroom cruelty.

Now, the highest court has sided with bans - against research showing this care improves mental health and saves lives.

💔 We stand with them. We demand science, dignity, and compassion.

zurl.co/QejZr

What to know about the impacts of the Supreme Court's ruling on transgender care for youth

The U.S. Supreme Court said Tennessee did not violate the constitution by banning gender-affirming care for transgender minors. The case is sure to resonate nationally.

zurl.co

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Dr Robert Bohan @robertbohan.bsky.social · Jun 20

🧵 Activists have broken into British Airforcs Base & carried out sabotage to try to help save Palestinian lives & prevent war crimes.

‘RAF Brize Norton military planes damaged as activists break into base ahead of flight.’ [1]

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Iso Hirst @isobelhirst.bsky.social · Jun 19

Really enjoying this review of time-resolved cryoEM 😊 especially this lovely summary figure ✍️
www.cell.com/structure/fu...

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Make Space for Girls @makespaceforgirls.bsky.social · Jun 19

Great to see the conversation in the US around how gender-blind design leaves girls out of parks.

Also great to see Brickfield Park in Bath mentioned – co-created with teenage girls, alongside inspiring examples from Vienna. Awareness is growing!

nextcity.org/urbanist-new...

Our Public Spaces Are Failing Teen Girls

Op-ed: Adolescent girls are missing from parks, playgrounds — and our gender-blind urban planning. So let’s ask them what they need.

nextcity.org

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Edward Nirenberg @enirenberg.bsky.social · Jun 18

Some good news. Tentatively.

HIV protection with just two shots a year: FDA approves Gilead drug www.statnews.com/2025/06/18/f... via @statnews.com

HIV protection with just two shots a year: FDA approves Gilead drug

A new twice-yearly shot could be a "game changer" in the fight against AIDS, but experts' hopes have dimmed because of the current political climate.

www.statnews.com

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Daniel Hurdiss @danielhurdiss.bsky.social · Jun 18

Latest preprint from the lab, many years in the making!

By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.

This could have big implications for our understanding of viral replication & assembly (🧵)

www.biorxiv.org/content/10.1...

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Nature @nature.com · Jun 16

Proteins operate on a short timescale — on the order of a millisecond, or even faster

https://go.nature.com/4l7qAEm

Freeze frame: cracking molecular motion

Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach.

go.nature.com

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Charlie Scarff @scarfflab.bsky.social · Jun 16

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com

PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

www.findaphd.com

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Iso Hirst @isobelhirst.bsky.social · Jun 2

@stemuench.bsky.social @rebeccathompson.bsky.social @mdarrow.bsky.social @scarfflab.bsky.social

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Iso Hirst @isobelhirst.bsky.social · Jun 2

I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩

www.sciencedirect.com/science/arti...

Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA

Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromolecules without requiring cry…

www.sciencedirect.com

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Thiago Carvalho @cyrilpedia.bsky.social · May 14

"I am hesitant to comment broadly on what it’s like for scientists now in America because I have only limited information about what is going on outside of this detention center. What I do know is that my colleagues, many of whom are, like me, foreign scientists, are terrified"

Thiago Carvalho @cyrilpedia.bsky.social · May 14

'I did not complete a customs declaration for frog embryos (...) this would normally result in a warning or fine. Instead, my visa was revoked & I was sent to a detention center in Louisiana, where I have spent the past 3 months with roughly 100 other women. We share one room w dormitory-style beds'

Opinion | I Came to Study Aging. Now I’m Trapped in ICE Detention.

www.nytimes.com

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Brady Johnston @bradyajohnston.bsky.social · Apr 29

Okay hear me out, what if building your protein model was a first person horror survival experience??

#MolecularNodes #b3d #GeometryNodes 🧪

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Mayor of London, Sadiq Khan @london.gov.uk · Apr 28

Young Londoners deserve opportunities across the EU.

A youth mobility scheme would strengthen ties with our neighbours, boost our economy and open doors for the next generation at a time of global uncertainty.

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