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Paul Frankland

@franklandlab.bsky.social

2.5K followers 570 following 160 posts

The neuroscience of memory, West Ham Utd, baguettes and other random stuff Neuroscientist at Hospital for Sick Children/University of Toronto

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Paul Frankland @franklandlab.bsky.social · 6d

a man singing california here we come on a screen

ALT: a man singing california here we come on a screen

media.tenor.com

Paul Frankland @franklandlab.bsky.social · 7d

This adds to an emerging picture that not only do new neurons influence encoding of new memories but they _shape_ and _remodel_ existing memories. These shifts in resolution may facilitate generalization of event based memories beyond the original situation.

Paul Frankland @franklandlab.bsky.social · 7d

Within hippocampal shifts in memory resolution depended on ongoing hippocampal neurogenesis. Blocking neurogenesis prevents time-dependent shifts in memory resolution, preserving hippocampal engrams in high fidelity ‘recent memory’-like states.

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Paul Frankland @franklandlab.bsky.social · 7d

We found hippocampal engrams were initially high resolution but lost resolution with time. In contrast, cortical engrams were low res and stayed low res over the course of systems consolidation

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Paul Frankland @franklandlab.bsky.social · 7d

In this paper we tracked the resolution of hippocampal and cortical components of an event memory (modifying a false memory paradigm first developed by @okaysteve.bsky.social). This allowed us to adjudicate between the different theoretical accounts of systems consolidation…

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Paul Frankland @franklandlab.bsky.social · 7d

Some favor inter-regional changes (e.g., hippocampus to cortex [multiple trace]) whereas other favor intra-regional changes (e.g., within hippocampus [trace transformation])

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Paul Frankland @franklandlab.bsky.social · 7d

Memories for events (i.e., episodic memories) tend to lose precision with time and models of systems consolidation propose that organizational changes accompany these shifts in memory resolution… but theories differ as to the locus of this reorganization…

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Paul Frankland @franklandlab.bsky.social · 7d

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:

authors.elsevier.com/a/1lsO73QW8S...

authors.elsevier.com

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Paul Frankland @franklandlab.bsky.social · 10d

Now seen all the greats. Messi, both Ronaldo’s, Ronaldinho and Alan Devonshire.

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Paul Frankland @franklandlab.bsky.social · 10d

Watching 38 year old man walk around for 90 mins

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Paul Frankland @franklandlab.bsky.social · Aug 27

Appreciate giving me 10!

Reposted by Paul Frankland

Taro Kitazawa @kitazawa-taro.bsky.social · Aug 16

In summary, we established whole-genome, multimodal single-cell history tracing, applicable to a wide range of experimental systems.
Our lab is now applying HisTrac to study id specification and plasticity (e.g., memory) and we look forward to sharing exciting results soon!

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Paul Frankland @franklandlab.bsky.social · Aug 14

Blue Jays win!

Paul Frankland @franklandlab.bsky.social · Aug 14

Working From Dome

Paul Frankland @franklandlab.bsky.social · Jul 20

Fantastic afternoon (so far) at the Skydome.

Paul Frankland @franklandlab.bsky.social · Jul 19

Yeah it feels like only about 25% of it is open right now. Gonna be great when it’s all done

Paul Frankland @franklandlab.bsky.social · Jul 19

Gotta get there early. Was only 1 or 2 of us early doors.

Paul Frankland @franklandlab.bsky.social · Jul 19

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Paul Frankland @franklandlab.bsky.social · Jul 19

Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.

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Reposted by Paul Frankland

Blake Richards @tyrellturing.bsky.social · Jun 25

Role and influence, yes. But, the biological mechanisms? Maybe not in a functional/systems/computational model...

Mind you, though I am not objective here, I basically buy @franklandlab.bsky.social's account of infantile amnesia as being driven by neurogenesis:

www.science.org/doi/full/10....

www.science.org

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Reposted by Paul Frankland

Kübra Gülmez Karaca @kubikubicv.bsky.social · Jun 20

It was a great pleasure to host Paul Frankand @franklandlab.bsky.social as the keynote speaker at the Dutch Neuroscience Meeting 2025 and at the Donders Institute. Big thanks to Paul for accepting our invitation, for the fantastic talks and discussions!

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Paul Frankland @franklandlab.bsky.social · May 30

For anyone in the memory field, an incredible summary and tribute to Endel Tulving from Gus Craik. Read it for the writing alone.

royalsocietypublishing.org/action/oidcS...

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Paul Frankland @franklandlab.bsky.social · May 29

But did they do it on a Friday???

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Paul Frankland @franklandlab.bsky.social · May 29

My mistake. Paper still rejected. Exception proves the rule!

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Paul Frankland @franklandlab.bsky.social · May 29

Ha! Thanks Kate!