James Fraser
@fraserlab.com
Professor and Chair @UCSF/@UCSF_BTS - dynamic structural biology and open science - (he/him) - fraserlab.com
A lot of the recent excitement around methods like AF3 (and followup methods which I often joking call YAAFCs: Yet Another Alpha Fold Clone) is the promise of modeling ligand-bound complexes from only a protein sequence + a small molecule SMILES string
(movie from Charm Therapeutics)
(movie from Charm Therapeutics)
December 29, 2025 at 10:29 PM
A lot of the recent excitement around methods like AF3 (and followup methods which I often joking call YAAFCs: Yet Another Alpha Fold Clone) is the promise of modeling ligand-bound complexes from only a protein sequence + a small molecule SMILES string
(movie from Charm Therapeutics)
(movie from Charm Therapeutics)