Kazzellin
@furasotakazzellin.bsky.social
Math teacher in-training, owned by cats. I also write, design and make jewelry in various medium, craft with 3D printing and Cricut machines, knit, cross stitch, make custom MLP toys, and run my business, Furasota, all while battling unofficial ADHD-PI.
Pinned
It starts. I must be out of my mind, trying to make an AI-created sweater dress a reality. 😅 But, we'll see how this goes!
Thus far, finding the yarn turned out to be the hardest part. I wanted to use a 5 or 6 for the weight, but the ones I had access to didn't have the dark brown. So #4 it is!
Thus far, finding the yarn turned out to be the hardest part. I wanted to use a 5 or 6 for the weight, but the ones I had access to didn't have the dark brown. So #4 it is!
Reposted by Kazzellin
I choose to take this as a positive omen.
(As named and drawn by Paul Kidby, illustrator of Discworld.)
(As named and drawn by Paul Kidby, illustrator of Discworld.)
December 17, 2025 at 1:37 PM
I choose to take this as a positive omen.
(As named and drawn by Paul Kidby, illustrator of Discworld.)
(As named and drawn by Paul Kidby, illustrator of Discworld.)
Reposted by Kazzellin
Psst.
Hey, come closer.
No, closer.
I have a New Year’s secret for you.
It’s this:
If you care about people you don’t even know, and try to live your life that way, you are absolutely beautiful no matter what you look like.
Hey, come closer.
No, closer.
I have a New Year’s secret for you.
It’s this:
If you care about people you don’t even know, and try to live your life that way, you are absolutely beautiful no matter what you look like.
January 1, 2026 at 8:59 AM
Psst.
Hey, come closer.
No, closer.
I have a New Year’s secret for you.
It’s this:
If you care about people you don’t even know, and try to live your life that way, you are absolutely beautiful no matter what you look like.
Hey, come closer.
No, closer.
I have a New Year’s secret for you.
It’s this:
If you care about people you don’t even know, and try to live your life that way, you are absolutely beautiful no matter what you look like.
Reposted by Kazzellin
These results bring hope that treatments like this will continue to advance and become available to more patients.
January 1, 2026 at 5:19 PM
These results bring hope that treatments like this will continue to advance and become available to more patients.
Reposted by Kazzellin
blood‑forming system. This combined strategy -intensive but time‑limited immune therapy, followed by transplant- is what offers a realistic chance of long‑term survival for some of these patients.
January 1, 2026 at 5:16 PM
blood‑forming system. This combined strategy -intensive but time‑limited immune therapy, followed by transplant- is what offers a realistic chance of long‑term survival for some of these patients.
Reposted by Kazzellin
following months. In other words, the engineered T-cells are not expected to provide lifelong control by themselves. Instead, they act as a very powerful but temporary strike against the leukemia, buying time for the patient to receive a transplant, which can then rebuild a healthy immune and
January 1, 2026 at 5:16 PM
following months. In other words, the engineered T-cells are not expected to provide lifelong control by themselves. Instead, they act as a very powerful but temporary strike against the leukemia, buying time for the patient to receive a transplant, which can then rebuild a healthy immune and
Reposted by Kazzellin
When patients receive base-edited CAR T-cells, the engineered cells quickly locate and destroy T-cells throughout the body, including the cancerous ones. If leukemia is cleared within the first month, patients then undergo a bone marrow transplant that restores a functioning immune system over the
January 1, 2026 at 5:15 PM
When patients receive base-edited CAR T-cells, the engineered cells quickly locate and destroy T-cells throughout the body, including the cancerous ones. If leukemia is cleared within the first month, patients then undergo a bone marrow transplant that restores a functioning immune system over the
Reposted by Kazzellin
particular study, the universal CAR T-cells came from the white blood cells of healthy donors. The engineering steps utilized custom RNA, mRNA, and a lentiviral vector in an automated system researchers previously refined.
January 1, 2026 at 5:15 PM
particular study, the universal CAR T-cells came from the white blood cells of healthy donors. The engineering steps utilized custom RNA, mRNA, and a lentiviral vector in an automated system researchers previously refined.
Reposted by Kazzellin
damage. Using CRISPR-based tools, researchers altered single DNA letters to reprogram the cells. In 2022, these edits allowed researchers to produce banked stores of "universal" CAR T-cells that could be delivered to different patients and still recognize and attack T-cell leukemia. For this
January 1, 2026 at 5:14 PM
damage. Using CRISPR-based tools, researchers altered single DNA letters to reprogram the cells. In 2022, these edits allowed researchers to produce banked stores of "universal" CAR T-cells that could be delivered to different patients and still recognize and attack T-cell leukemia. For this
Reposted by Kazzellin
has been especially difficult. The challenge is that the treatment must wipe out cancerous T-cells WITHOUT triggering the engineered cells to attack one another. BE-CAR7 T-cells are created with a next-generation genome editing method that does NOT cut DNA, which lowers the chances of chromosomal
January 1, 2026 at 5:14 PM
has been especially difficult. The challenge is that the treatment must wipe out cancerous T-cells WITHOUT triggering the engineered cells to attack one another. BE-CAR7 T-cells are created with a next-generation genome editing method that does NOT cut DNA, which lowers the chances of chromosomal
Reposted by Kazzellin
The process modifies a patient's T-cells so they carry a customized protein called a chimeric antigen receptor (CAR). This receptor helps the modified cell identify unique markers or "flags" on cancer cells and destroy them. Developing CAR T-cell therapies for leukemias that originate in T-cells
January 1, 2026 at 5:13 PM
The process modifies a patient's T-cells so they carry a customized protein called a chimeric antigen receptor (CAR). This receptor helps the modified cell identify unique markers or "flags" on cancer cells and destroy them. Developing CAR T-cell therapies for leukemias that originate in T-cells
Reposted by Kazzellin
detect leukemia. This then opened the door to a stem cell or bone marrow transplant from a donor, which remains the only realistic route to a long‑term cure for these patients.
So, how does CAR T-cell therapy work? CAR-T cell immunotherapy has become an important option for several blood cancers.
So, how does CAR T-cell therapy work? CAR-T cell immunotherapy has become an important option for several blood cancers.
January 1, 2026 at 5:12 PM
detect leukemia. This then opened the door to a stem cell or bone marrow transplant from a donor, which remains the only realistic route to a long‑term cure for these patients.
So, how does CAR T-cell therapy work? CAR-T cell immunotherapy has become an important option for several blood cancers.
So, how does CAR T-cell therapy work? CAR-T cell immunotherapy has become an important option for several blood cancers.
Reposted by Kazzellin
switched off or altered key molecules on the donor T-cells so that they could slip past the patient's immune defences and focus their attack on the leukemia cells. In early studies, some patients with no remaining treatment options achieved deep remissions, where even sensitive tests could no longer
January 1, 2026 at 5:12 PM
switched off or altered key molecules on the donor T-cells so that they could slip past the patient's immune defences and focus their attack on the leukemia cells. In early studies, some patients with no remaining treatment options achieved deep remissions, where even sensitive tests could no longer
Reposted by Kazzellin
In T‑cell leukaemia, the cancer itself is made of T-cells, so simply adding more T-cells from outside would normally cause friendly fire: the therapeutic cells would attack each other as well as the cancer or be rejected by the patient's immune system. By using gene‑editing tools, researchers
January 1, 2026 at 5:11 PM
In T‑cell leukaemia, the cancer itself is made of T-cells, so simply adding more T-cells from outside would normally cause friendly fire: the therapeutic cells would attack each other as well as the cancer or be rejected by the patient's immune system. By using gene‑editing tools, researchers
Reposted by Kazzellin
of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine and were shared at the 67th American Society of Hematology Annual Meeting. The results show STRONG remission rates.
January 1, 2026 at 5:10 PM
of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine and were shared at the 67th American Society of Hematology Annual Meeting. The results show STRONG remission rates.
Reposted by Kazzellin
prepared in advance as an "off-the-shelf" product and given quickly to people in urgent need. For families facing a disease that has returned after every standard treatment, a ready-made therapy that can clear leukemia to UNDETECTABLE levels is a MAJOR step forward. The latest clinical trial results
January 1, 2026 at 5:08 PM
prepared in advance as an "off-the-shelf" product and given quickly to people in urgent need. For families facing a disease that has returned after every standard treatment, a ready-made therapy that can clear leukemia to UNDETECTABLE levels is a MAJOR step forward. The latest clinical trial results
Reposted by Kazzellin
CRISPR that changes individual DNA letters inside living cells with high precision. In other words, BE-CAR7 uses T-cells from a healthy donor, reengineered in the lab to recognize and attack leukemia cells. Unlike personalized cancer therapies made from each patient's own cells, these can be
January 1, 2026 at 5:07 PM
CRISPR that changes individual DNA letters inside living cells with high precision. In other words, BE-CAR7 uses T-cells from a healthy donor, reengineered in the lab to recognize and attack leukemia cells. Unlike personalized cancer therapies made from each patient's own cells, these can be
Reposted by Kazzellin
cells to target the disease in patients who often have VERY LIMITED treatment options. This first-of-its-kind gene therapy, known as BE-CAR7, relies on base-edited immune cells to attack types of T-cell leukemia that historically could not be treated effectively. Base-editing is an advanced form of
January 1, 2026 at 5:06 PM
cells to target the disease in patients who often have VERY LIMITED treatment options. This first-of-its-kind gene therapy, known as BE-CAR7, relies on base-edited immune cells to attack types of T-cell leukemia that historically could not be treated effectively. Base-editing is an advanced form of
Reposted by Kazzellin
A new treatment created by researchers at UCL (University College London) and Great Ormond Street Hospital (GOSH) is offering promising results for children and adults with T-cell acute lymphoblastic leukemia (T-ALL), a fast-moving and uncommon blood cancer. Their approach uses genome-edited immune
January 1, 2026 at 5:05 PM
A new treatment created by researchers at UCL (University College London) and Great Ormond Street Hospital (GOSH) is offering promising results for children and adults with T-cell acute lymphoblastic leukemia (T-ALL), a fast-moving and uncommon blood cancer. Their approach uses genome-edited immune
Reposted by Kazzellin
The Phase I results of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine.
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
January 1, 2026 at 5:04 PM
The Phase I results of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine.
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
Reposted by Kazzellin
The groundbreaking new treatment using genome-edited immune cells, developed by researchers at University College London and Great Ormond Street Hospital has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer.
• www.ucl.ac.uk/news/2025/de...
• www.ucl.ac.uk/news/2025/de...
January 1, 2026 at 5:02 PM
The groundbreaking new treatment using genome-edited immune cells, developed by researchers at University College London and Great Ormond Street Hospital has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer.
• www.ucl.ac.uk/news/2025/de...
• www.ucl.ac.uk/news/2025/de...
Reposted by Kazzellin
GOOD NEWS! A group of patients with an otherwise incurable form of T‑cell leukemia have seen their cancer driven into REMISSION by an innovative immune therapy known as BE-CAR7. 82% of patients reached deep remission and 64% of patients have now been disease-free and OFF therapy for THREE years.
January 1, 2026 at 5:00 PM
GOOD NEWS! A group of patients with an otherwise incurable form of T‑cell leukemia have seen their cancer driven into REMISSION by an innovative immune therapy known as BE-CAR7. 82% of patients reached deep remission and 64% of patients have now been disease-free and OFF therapy for THREE years.
Barely through the first day of the new year, and I've already made a goal!
I bookmarked and closed or just closed all the open tabs on the two internet browsers on my phone.
Given the one had over a hundred open tabs (from links and such), my phone might run better!
#SmallSteps #NewYearGoals
I bookmarked and closed or just closed all the open tabs on the two internet browsers on my phone.
Given the one had over a hundred open tabs (from links and such), my phone might run better!
#SmallSteps #NewYearGoals
January 1, 2026 at 5:28 PM
Barely through the first day of the new year, and I've already made a goal!
I bookmarked and closed or just closed all the open tabs on the two internet browsers on my phone.
Given the one had over a hundred open tabs (from links and such), my phone might run better!
#SmallSteps #NewYearGoals
I bookmarked and closed or just closed all the open tabs on the two internet browsers on my phone.
Given the one had over a hundred open tabs (from links and such), my phone might run better!
#SmallSteps #NewYearGoals
Reposted by Kazzellin
I have killed my reg and AD accounts there (~11k followers overall) back in January and I kid you not: I just forgot about it all.
My life got much simpler. I wasn't talking to 9k of these people.
Within a week, it was just a thing of the past.
My life got much simpler. I wasn't talking to 9k of these people.
Within a week, it was just a thing of the past.
December 18, 2025 at 9:19 AM
I have killed my reg and AD accounts there (~11k followers overall) back in January and I kid you not: I just forgot about it all.
My life got much simpler. I wasn't talking to 9k of these people.
Within a week, it was just a thing of the past.
My life got much simpler. I wasn't talking to 9k of these people.
Within a week, it was just a thing of the past.