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Juan Fuxman Bass @fuxmanlab.bsky.social · 5d

Congrats! Amazing work!

Juan Fuxman Bass @fuxmanlab.bsky.social · 12d

Amazing work. Congrats!

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Juan Fuxman Bass @fuxmanlab.bsky.social · 27d

This is big!

siddhartha jena @epijenatics.bsky.social · 27d

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

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Juan Fuxman Bass @fuxmanlab.bsky.social · Aug 29

We work on gene regulatory networks, in particular related to viruses.

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Juan Fuxman Bass @fuxmanlab.bsky.social · Aug 8

Excited to share this collaborative review with @dsegre.bsky.social and @devmoy.bsky.social. We discuss common issues with context-specific genome-scale metabolic network models and provide recommendation for future model development.

Daniel Segrè @dsegre.bsky.social · Aug 8

Just published @cp-trendsbiotech: Flux sampling and context-specific genome-scale metabolic models for biotechnological applications: www.cell.com/trends/biote... by @devmoy, with @fuxmanlab

Flux sampling and context-specific genome-scale metabolic models for biotechnological applications

Genome-scale metabolic models are used in fields ranging from metabolic engineering to drug discovery and microbiome design. Although these models are often used to predict putatively optimal states, ...

www.cell.com

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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

Amazing work by Tommy Taslim, Joseph Finkelberg, Susan Kales, and many other members of Ryan's and my lab.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

Finally, we found several CREs that are activated by different signals, such as interferon gamma and dexamethasone, which may contribute to viral reactivation or immune evasion mechanisms.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

We also show how that the genomes of different herpesviruses have very different CRE landscapes, with different proportion of promoter-like, proximal, distal, and CTF-only CREs, different activity levels, and different localization.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

One of these regions (Psi) is present in most adenoviral vectors and contributes to basal transgene expression. We mutated this region, without affecting packaging capacity, which led to reduced basal activity and increased inducibility.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

We also identify many novel CREs in adenoviral genomes, some conserved across strains and isolates and others highly variable.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

By testing multiple isolates and performing saturation mutagenesis experiments, we identify regions in the HPV long control region that are highly variable in activity and the nucleotide changes responsible for such variability.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

Contrary to human CREs, most virus CREs are promoter-like and overlap with coding sequences. These CREs are regulated by TFs such as SP/KLF, ETS factors, CREB, YY1 and others.
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Juan Fuxman Bass @fuxmanlab.bsky.social · Jul 24

Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social!
We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families.
www.biorxiv.org/content/10.1...
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Juan Fuxman Bass @fuxmanlab.bsky.social · May 23

Congrats Alex!

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Reposted by Juan Fuxman Bass

Dr. Lucky Tran @luckytran.com · Apr 28

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

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Juan Fuxman Bass @fuxmanlab.bsky.social · Apr 10

Congrats Sebastian!

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Juan Fuxman Bass @fuxmanlab.bsky.social · Mar 27

Congrats Polly!!! Super well-deserved!

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Juan Fuxman Bass @fuxmanlab.bsky.social · Mar 26

Exited to share our recent work on TF isoforms! Amazing work by @kaiamattioli.bsky.social Luke Lambourne and Clarissa Santoso and many other collaborators.

Kaia Mattioli @kaiamattioli.bsky.social · Mar 26

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!

key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity

many are "negative regulators" & misexpressed in cancer

www.sciencedirect.com/science/arti...

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Reposted by Juan Fuxman Bass

Mark Cuban @mcuban.bsky.social · Mar 22

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

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Reposted by Juan Fuxman Bass

Dr. Lucky Tran @luckytran.com · Mar 18

Scientists are unfairly and devastatingly seeing their grants cut and careers thrown into uncertainty, yet are still working 24/7 to continue their research, treat patients, talk to journalists, advocate with elected officials, and keep the public informed about potential threats. Absolute heroes!

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Reposted by Juan Fuxman Bass

Kelton Minor @keltonminor.bsky.social · Mar 18

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵

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Reposted by Juan Fuxman Bass

Kevin Collins @kwcollins.bsky.social · Mar 17

Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.

They’re throwing away a cure for cancer.

Alex Wayne @aawayne.bsky.social · Mar 16

Exclusive: NIH officials have advised scientists to remove reference to mRNA vaccines from their grant applications, in expectation the Trump administration intends to abandon most research in the field.

By @arthurallen202.bsky.social

kffhealthnews.org/news/article...

Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants - KFF Health News

Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...

kffhealthnews.org

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Reposted by Juan Fuxman Bass

Rachael Sirianni, PhD @docsirianni.bsky.social · Mar 15

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

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Reposted by Juan Fuxman Bass

Anonymous @youranoncentral.bsky.social · Mar 7

The Stand Up For Science protests have kicked off worldwide. Thousands of scientists demonstrated in solidarity with their US counterparts across France to defend the scientific community. (📹 @Margot_Brunet_)

#3E #FranceProtests #USprotests #March7Science #StandUpForScience #Mar7

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Reposted by Juan Fuxman Bass

Ben Ewen-Campen @benforward3.bsky.social · Mar 7

✊Massive turnout for STAND UP FOR SCIENCE rally in Boston #StandUpForScience

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