Gauthier Toulouse
@gauthier-tlse.bsky.social
Post-doctoral fellow in Christophe Marcelle lab
Chicken embryo, Somites, Myogenesis, Anatomy, Evo-Devo
Chicken embryo, Somites, Myogenesis, Anatomy, Evo-Devo
Reposted by Gauthier Toulouse
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Gauthier Toulouse
That’s a wrap on the Avian Model Systems Meeting at the Institute! 🐦✨
Scientists came together in KC to share discoveries & highlight the power of birds in advancing biology—from evolution to regeneration. Thanks to all who joined!💡🌍
#AvianModels2025 #Biology #Science
Scientists came together in KC to share discoveries & highlight the power of birds in advancing biology—from evolution to regeneration. Thanks to all who joined!💡🌍
#AvianModels2025 #Biology #Science
October 1, 2025 at 11:20 PM
That’s a wrap on the Avian Model Systems Meeting at the Institute! 🐦✨
Scientists came together in KC to share discoveries & highlight the power of birds in advancing biology—from evolution to regeneration. Thanks to all who joined!💡🌍
#AvianModels2025 #Biology #Science
Scientists came together in KC to share discoveries & highlight the power of birds in advancing biology—from evolution to regeneration. Thanks to all who joined!💡🌍
#AvianModels2025 #Biology #Science
Super happy to share the first part of my PhD work that highlights how tracing cells by their integrated response to a signaling pathway can inform about their specific lineage during muscle development ! Everything done using chicken embryos 🐣
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells - Nature Communications
This study shows that two distinct progenitor populations build embryonic muscle in birds—one forms primary fibers via Wnt signaling, the other gives rise to secondary fibers and satellite cells—and t...
www.nature.com
August 23, 2025 at 8:33 AM
Super happy to share the first part of my PhD work that highlights how tracing cells by their integrated response to a signaling pathway can inform about their specific lineage during muscle development ! Everything done using chicken embryos 🐣
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gauthier Toulouse
Excited to announce that our new paper is now published in Science Advances 🚀🧠 ‘Acquisition of neural crest promoted thyroid evolution from chordate endostyle’ — check it out here: www.science.org/doi/10.1126/...
Acquisition of neural crest promoted thyroid evolution from chordate endostyle
Integration of neural crest cells into the endostyle developmental program promoted its evolution into the thyroid gland.
www.science.org
August 13, 2025 at 3:33 PM
Excited to announce that our new paper is now published in Science Advances 🚀🧠 ‘Acquisition of neural crest promoted thyroid evolution from chordate endostyle’ — check it out here: www.science.org/doi/10.1126/...
Reposted by Gauthier Toulouse
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
July 19, 2025 at 8:19 AM
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
Reposted by Gauthier Toulouse
Registration is OPEN for the XII Avian Model Systems Meeting! Join us to explore how avian models continue to shape discoveries in developmental #biology, #neuroscience, genomics, medicine, and #evolution.
📅 Don’t miss #AvianModels25: bit.ly/3ZBw2qS
📅 Don’t miss #AvianModels25: bit.ly/3ZBw2qS
July 18, 2025 at 7:25 PM
Registration is OPEN for the XII Avian Model Systems Meeting! Join us to explore how avian models continue to shape discoveries in developmental #biology, #neuroscience, genomics, medicine, and #evolution.
📅 Don’t miss #AvianModels25: bit.ly/3ZBw2qS
📅 Don’t miss #AvianModels25: bit.ly/3ZBw2qS
Reposted by Gauthier Toulouse
Join us next week for our Western 🌙 KEYNOTE seminar:
🗓️ Thursday, July 17
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers are:
Josh Brickman @josh-brickman.bsky.social
Charlene Guillot @charleneguillot.bsky.social
We are looking forward to this great season finale! 🥳
🗓️ Thursday, July 17
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers are:
Josh Brickman @josh-brickman.bsky.social
Charlene Guillot @charleneguillot.bsky.social
We are looking forward to this great season finale! 🥳
July 12, 2025 at 8:35 PM
Join us next week for our Western 🌙 KEYNOTE seminar:
🗓️ Thursday, July 17
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers are:
Josh Brickman @josh-brickman.bsky.social
Charlene Guillot @charleneguillot.bsky.social
We are looking forward to this great season finale! 🥳
🗓️ Thursday, July 17
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers are:
Josh Brickman @josh-brickman.bsky.social
Charlene Guillot @charleneguillot.bsky.social
We are looking forward to this great season finale! 🥳
Reposted by Gauthier Toulouse
12th Avian Model Systems Meeting bit.ly/3ZBw2qS @stowersinstitute.bsky.social. We will be joined by Marianne Bronner, Olivier Pourquié, Megan Davey, Julie Elie, @jeromegros.bsky.social, Carols Lois, Peter Lwigale, Alan Rodrigues, Marcos Simoes-Costa, @melaniedwhite.bsky.social and YOU!
Research Organisms in Flight: Revealing the Roots of Vertebrate Form…
Organized by Tatjana Sauka-Spengler, Ph.D., and Ruth Williams, Ph.D.
bit.ly
July 11, 2025 at 10:33 AM
12th Avian Model Systems Meeting bit.ly/3ZBw2qS @stowersinstitute.bsky.social. We will be joined by Marianne Bronner, Olivier Pourquié, Megan Davey, Julie Elie, @jeromegros.bsky.social, Carols Lois, Peter Lwigale, Alan Rodrigues, Marcos Simoes-Costa, @melaniedwhite.bsky.social and YOU!
Reposted by Gauthier Toulouse
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
July 7, 2025 at 6:47 AM
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
Reposted by Gauthier Toulouse
Registration NOW open for the XII Avian Model Systems Meeting—hosted at the Institute this fall! Join us for a vibrant and highly interactive conference that highlights the powerful role of avian models in advancing #research. #AvianModels25
Learn more + register: bit.ly/3ZBw2qS
Learn more + register: bit.ly/3ZBw2qS
June 25, 2025 at 5:26 PM
Registration NOW open for the XII Avian Model Systems Meeting—hosted at the Institute this fall! Join us for a vibrant and highly interactive conference that highlights the powerful role of avian models in advancing #research. #AvianModels25
Learn more + register: bit.ly/3ZBw2qS
Learn more + register: bit.ly/3ZBw2qS
Reposted by Gauthier Toulouse
The 12th Avian Model Systems Meeting is happening this fall!! tinyurl.com/2s3mynw6 We hope you can join us at the Stowers Institute @stowersinstitute.bsky.social, Kansas City to talk all things birds, biology and breakthroughs!! 🐣🐔🪶
Research Organisms in Flight: Revealing the Roots of Vertebrate Form…
Organized by Tatjana Sauka-Spengler, Ph.D., and Ruth Williams, Ph.D.
tinyurl.com
June 25, 2025 at 9:06 PM
The 12th Avian Model Systems Meeting is happening this fall!! tinyurl.com/2s3mynw6 We hope you can join us at the Stowers Institute @stowersinstitute.bsky.social, Kansas City to talk all things birds, biology and breakthroughs!! 🐣🐔🪶
Reposted by Gauthier Toulouse
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
June 6, 2025 at 11:39 AM
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Reposted by Gauthier Toulouse
Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head
Biological sciences; Zoology; Evolutionary biology
www.cell.com
June 4, 2025 at 2:39 PM
Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
Reposted by Gauthier Toulouse
🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction
In birds and mammals, the formation of the primitive streak, the hallmark of the primary axis and site of gastrulation, is thought to occur when an anterior displacement of the hypoblast (visceral end...
doi.org
May 19, 2025 at 8:59 AM
🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Reposted by Gauthier Toulouse
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
May 12, 2025 at 2:01 PM
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Reposted by Gauthier Toulouse
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
May 10, 2025 at 11:15 AM
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Gauthier Toulouse
Attention #devbio and #stemcell crew! @natcomms.nature.com is looking for submissions related to developmental organizers, self organization, and symmetry breaking. More details on the collection page. www.nature.com/collections/...
Organizers and self-organization in developmental biology
This collection highlights papers studying self-organization, symmetry breaking, and developmental organizers.
www.nature.com
May 8, 2025 at 10:44 AM
Attention #devbio and #stemcell crew! @natcomms.nature.com is looking for submissions related to developmental organizers, self organization, and symmetry breaking. More details on the collection page. www.nature.com/collections/...
Reposted by Gauthier Toulouse
Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung
Read this Research Article by Kamryn Gerner-Mauro @kamryngerner.bsky.social, Jichao Chen and colleagues:
journals.biologists.com/dev/article/...
Read this Research Article by Kamryn Gerner-Mauro @kamryngerner.bsky.social, Jichao Chen and colleagues:
journals.biologists.com/dev/article/...
April 29, 2025 at 3:29 PM
Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung
Read this Research Article by Kamryn Gerner-Mauro @kamryngerner.bsky.social, Jichao Chen and colleagues:
journals.biologists.com/dev/article/...
Read this Research Article by Kamryn Gerner-Mauro @kamryngerner.bsky.social, Jichao Chen and colleagues:
journals.biologists.com/dev/article/...
Reposted by Gauthier Toulouse
This time-lapse captures 17 hours of axonal growth from a chicken dorsal root ganglion explant, visualized through the actin cytoskeleton using live confocal imaging.
I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉
🧪
I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉
🧪
April 30, 2025 at 7:16 AM
This time-lapse captures 17 hours of axonal growth from a chicken dorsal root ganglion explant, visualized through the actin cytoskeleton using live confocal imaging.
I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉
🧪
I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉
🧪
Reposted by Gauthier Toulouse
Do you like Dev Bio ? Yes !
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
April 18, 2025 at 3:28 PM
Do you like Dev Bio ? Yes !
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Reposted by Gauthier Toulouse
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
April 7, 2025 at 7:16 AM
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
Reposted by Gauthier Toulouse
We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...
April 3, 2025 at 12:07 AM
We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...
Reposted by Gauthier Toulouse
🚨🐣 Our new paper is out @plosbiology.org! Sonic hedgehog inhibition transforms feathers into ancestral protofeathers-like structures. These units then recover after hatching, highlighting their remarkable developmental robustness! @lanevol.bsky.social 🧪
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken
The Sonic Hedgehog (Shh) pathway is a key regulator of feather development. These authors show that in vivo Shh inhibition during early chicken embryogenesis temporarily results in unbranched and non-...
journals.plos.org
March 20, 2025 at 6:05 PM
🚨🐣 Our new paper is out @plosbiology.org! Sonic hedgehog inhibition transforms feathers into ancestral protofeathers-like structures. These units then recover after hatching, highlighting their remarkable developmental robustness! @lanevol.bsky.social 🧪
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Gauthier Toulouse
Our preprint is out! Kudos to @josanesousa.bsky.social, @gabrielalima19.bsky.social, @perezlouise.bsky.social and undergraduate prodigy Hannah Shof! By comparing Polypterus fin and axolotl limb we find shared and new regeneration programs. @lsuscience.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 15, 2025 at 4:02 PM
Our preprint is out! Kudos to @josanesousa.bsky.social, @gabrielalima19.bsky.social, @perezlouise.bsky.social and undergraduate prodigy Hannah Shof! By comparing Polypterus fin and axolotl limb we find shared and new regeneration programs. @lsuscience.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gauthier Toulouse
🔥🔥🔥 New preprint!
Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy.
www.biorxiv.org/content/10.1... #MyoBlue
Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy.
www.biorxiv.org/content/10.1... #MyoBlue
Impaired stem cell migration and divisions in Duchenne Muscular Dystrophy revealed by live imaging
Dysregulation of stem cell properties is a hallmark of many pathologies, but the dynamic behaviour of stem cells in their microenvironment during disease progression remains poorly understood. Using t...
www.biorxiv.org
March 14, 2025 at 3:23 PM
🔥🔥🔥 New preprint!
Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy.
www.biorxiv.org/content/10.1... #MyoBlue
Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy.
www.biorxiv.org/content/10.1... #MyoBlue